Crocetin

Crocetin
Crocetin
General
Systematic ; name	(2 E , 4 E , 6 E , 8 E , 10 E , 12 E , 14 E ) -2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptadiene acid
Chem. formula	C 20 H 24 O 4
Physical properties
condition	solid, crystalline
Molar mass	976.972 g / mol
Thermal properties
T. melt.	285 ° C
Classification
Reg. CAS number	27876-94-4
PubChem
Reg. EINECS number	248-708-0
Smiles
Inchi
Chebi	3918
ChemSpider

Crocetin is an organic compound , apocarotinoid dicarboxylic acid, found in flowers of saffron (crocus) plants and in gardenia fruits ^[1] .

Content

1 Description
2 In physiology
3 notes
4 References

Description

Saffron flowers ( Crocus sativus ).

Crocetin is a carotenoid heptane unsaturated carboxylic acid . In its pure form forms a brick red crystals. It is the basic structural component of crocin , a compound that gives color to such a famous spice as saffron .

In Physiology

Oral administration of crocetin reduced physical fatigue in healthy subjects ^[2] . Crocetin can also improve sleep quality with moderate impairment ^[3] .

At high doses, crocetin showed a protective effect against retina damage ^[4] .

Notes

↑ Chemical Information (neopr.) (Inaccessible link) . sun.ars-grin.gov. Date of treatment March 2, 2008. Archived on November 8, 2004.
↑ Mizuma H., Tanaka M., Nozaki S., Mizuno K., Tahara T., Ataka S., Sugino T., Shirai T., Kajimoto Y., Kuratsune H., Kajimoto O., Watanabe Y. Daily oral administration of crocetin attenuates physical fatigue in human subjects // Nutrition Research: journal. - 2009 .-- March ( vol. 29 , no. 3 ). - P. 145-150 . - DOI : 10.1016 / j.nutres.2009.02.003 . - PMID 19358927 .
↑ Kuratsune H., Umigai N., Takeno R., Kajimoto Y., Nakano T. Effect of crocetin from Gardenia jasminoides Ellis on sleep: a pilot study (Eng.) // Phytomedicine: journal. - 2010 .-- September ( vol. 17 , no. 11 ). - P. 840-843 . - DOI : 10.1016 / j.phymed.2010.03.0.025 . - PMID 20537515 .
↑ Yamauchi, M; Tsuruma, K; Imai, S; Nakanishi, T; Umigai, N; Shimazawa, M; Hara, H. Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity (English) // European Journal of Pharmacology : journal. - 2011. - Vol. 650 , no. 1 . - P. 110-119 . - DOI : 10.1016 / j.ejphar.2010.09.0.081 . - PMID 20951131 .

Links

Crocetin (neopr.) . Chemist's Handbook 21. Date of treatment August 29, 2019.

[1] Chemical Information (neopr.) (Inaccessible link) . sun.ars-grin.gov. Date of treatment March 2, 2008. Archived on November 8, 2004.

[2] Mizuma H., Tanaka M., Nozaki S., Mizuno K., Tahara T., Ataka S., Sugino T., Shirai T., Kajimoto Y., Kuratsune H., Kajimoto O., Watanabe Y. Daily oral administration of crocetin attenuates physical fatigue in human subjects // Nutrition Research: journal. - 2009 .-- March ( vol. 29 , no. 3 ). - P. 145-150 . - DOI : 10.1016 / j.nutres.2009.02.003 . - PMID 19358927 .

[3] Kuratsune H., Umigai N., Takeno R., Kajimoto Y., Nakano T. Effect of crocetin from Gardenia jasminoides Ellis on sleep: a pilot study (Eng.) // Phytomedicine: journal. - 2010 .-- September ( vol. 17 , no. 11 ). - P. 840-843 . - DOI : 10.1016 / j.phymed.2010.03.0.025 . - PMID 20537515 .

[4] Yamauchi, M; Tsuruma, K; Imai, S; Nakanishi, T; Umigai, N; Shimazawa, M; Hara, H. Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity (English) // European Journal of Pharmacology : journal. - 2011. - Vol. 650 , no. 1 . - P. 110-119 . - DOI : 10.1016 / j.ejphar.2010.09.0.081 . - PMID 20951131 .