Epigallocatechin Gallate (EGCG) is a type of catechin found in large quantities in tea . The formula of the compound is C 22 H 18 O 11 . The molecular weight is 458.372 g / mol. At present, the effect of epigallocatechin gallate in cancer, multiple sclerosis [1] , HIV infection, on brain activity, skin condition, etc. is being studied.
Content
- 1 Anticancer properties of the compound
- 1.1 EGCG and breast cancer
- 1.2 EGCG and skin cancer
- 1.3 Results are disputed
- 2 EGCG and brain
- 2.1 Reducing the risk of memory and attention disorders
- 3 EGCG and HIV
- 4 Hepatotoxicity
- 5 Links
- 6 See also
Anticancer properties of the compound
EGCG and Breast Cancer
One carcinogenesis study notes the ability of green tea in combination with tamoxifen to inhibit the development of breast cancer in humans ( in vitro ) and in mice ( in vivo ) [2] .
EGCG and Skin Cancer
Epigallocatechin gallate may help protect the skin from the harmful effects of ultraviolet radiation and prevent the formation of tumors [3] . In addition, it can combat the manifestations of skin aging.
Disputed Results
Tests conducted by the Food and Drug Administration of the United States , allowed her to challenge the claim that the consumption of green tea reduces the risk of breast cancer and prostate cancer [4] .
EGCG and the brain
Reducing the risk of memory and attention disorders
The study showed that older Japanese people who drank more than 2 cups of green tea per day had a 50% lower risk of memory and attention disorders than those who drank less than 2 cups or other tested drinks [5] .
EGCG and HIV
Hepatotoxicity
According to studies [6] , a therapeutically significant amount of EGCG is contained in about 10-16 cups of green tea per day, and such an amount is physically difficult to drink at a time; In addition, side effects in the form of nausea and heartburn can occur. Clinically recorded effects appear when 800β850 mg of green tea extract is consumed per day, but with such an amount, EGCG has a hepatotoxic effect [7] .
Links
- β Neurodegeneration in autoimmune demyelination: Recent mechanistic insights reveal novel therapeutic targets. Orhan Aktas, Sonia Waiczies, Frauke Zipp Archived copy (Inaccessible link) . Date of treatment June 5, 2017. Archived on August 11, 2017.
- β βThe combination of green tea and tamoxifen is effective against breast cancer.β Sartippour MR, et al. Carcinogenesis. 2006 Dec; 27 (12): 2424-33. Epub 2006 Jun 19.
- β Katiyar S., Elmets CA, Katiyar SK Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair (Eng.) // J. Nutr. Biochem. : journal. - 2007. - Vol. 18 , no. 5 . - P. 287-296 . - DOI : 10.1016 / j.jnutbio.2006.08.004 . - PMID 17049833 .
- β FDA Issues Information for Consumers about Claims for Green Tea and Certain Cancers
- β The American Journal of Clinical Nutrition (Vol. 83, pp. 355-361).
- β Alexey Vodovozov . Angry critic: He's green tea // "XX2 century", 09/20/2019
- β The safety of green tea and green tea extract consumption in adults - Results of a systematic review // Regulatory Toxicology and Pharmacology, Volume 95, June 2018, Pages 412-433
See also
- Catechin
- Tea
- Cancer