Alpha- (1, 6) -fucosyltransferase , or fucosyltransferase 8 ] [2] . Plays a role in glycosylation of proteins.
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Content
Functions
The enzyme catalyzes the addition of fucose through an alpha-1,6-glycosidic bond of the 1st residue of N-acetylglucosamine , which is closest to the N-glycan peptide chain.
Structure and intracellular localization
FUT8 consists of 575 amino acids , a molecular weight of 66.5 kDa. Like other fucosyltransferases , it is localized on the membranes of the trans-section of the Golgi apparatus .
Expression
Expressed in almost all tans, the highest level of expression is in the nerve plexus of the corpus callosum of the brain.
Pathology
Mutations of the fucosyltransferase 8 gene can lead to a disease of a hereditary glycosylation disorder with defective fucosylation (so-called CDGF). In connection with the multiple functions of protein glycosylation, the disease is characterized by a wide range of clinical manifestations: defects in the development of the nervous system, psychomotor retardation, dysmorphisms, hypotension, coagulation disorders and immunodeficiency. CDGF is an autosomal recessive disorder.
See also
- Fucosyl transferase
Notes
- ↑ Costache M., Apoil PA, Cailleau A., Elmgren A., Larson G., Henry S., Blancher A., Iordachescu D., Oriol R., Mollicone R. Evolution of fucosyltransferase genes in vertebrates (English) / / J Biol Chem : journal. - 1997 .-- December ( vol. 272 , no. 47 ). - P. 29721-29728 . - DOI : 10.1074 / jbc.272.47.29721 . - PMID 9368041 .
- ↑ Entrez Gene: FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) .
Literature
- Miyoshi E., Noda K., Yamaguchi Y. et al. The alpha1-6-fucosyltransferase gene and its biological significance. (English) // Biochim. Biophys. Acta : journal. - 2000. - Vol. 1473 , no. 1 . - P. 9-20 . - DOI : 10.1016 / s0304-4165 (99) 00166-x . - PMID 10580126 .
- Kalyanaraman VS, Rodriguez V., Veronese F. et al. Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1. (eng.) // AIDS Res. Hum. Retroviruses : journal. - 1990. - Vol. 6 , no. 3 . - P. 371-380 . - DOI : 10.1089 / aid.1990.6.371 . - PMID 2187500 .
- Pal R., Hoke GM, Sarngadharan MG Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1. (Eng.) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 1989. - Vol. 86 , no. 9 . - P. 3384-3388 . - DOI : 10.1073 / pnas.86.9.3384 . - PMID 2541446 .
- Dewar RL, Vasudevachari MB, Natarajan V., Salzman NP Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport. (English) // J. Virol. : journal. - 1989. - Vol. 63 , no. 6 . - P. 2452-2456 . - PMID 2542563 .
- Kozarsky K., Penman M., Basiripour L. et al. Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein. (English) // J. Acquir. Immune Defic. Syndr. : journal. - 1989. - Vol. 2 , no. 2 . - P. 163-169 . - PMID 2649653 .
- Robinson WE, Montefiori DC, Mitchell WM Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis. (Eng.) // AIDS Res. Hum. Retroviruses : journal. - 1988. - Vol. 3 , no. 3 . - P. 265-282 . - DOI : 10.1089 / aid.1987.3.265 . - PMID 2829950 .
- Andersson B., Wentland MA, Ricafrente JY et al. A "double adapter" method for improved shotgun library construction. (Eng.) // Anal. Biochem. : journal. - 1996. - Vol. 236 , no. 1 . - P. 107-113 . - DOI : 10.1006 / abio.1996.0138 . - PMID 8619474 .
- Yu W., Andersson B., Worley KC et al. Large-scale concatenation cDNA sequencing. (Eng.) // Genome Res. : journal. - 1997. - Vol. 7 , no. 4 . - P. 353-358 . - DOI : 10.1101 / gr . 7.4.353 . - PMID 9110174 .
- Yanagidani S., Uozumi N., Ihara Y. et al. Purification and cDNA cloning of GDP-L-Fuc: N-acetyl-beta-D-glucosaminide: alpha1-6 fucosyltransferase (alpha1-6 FucT) from human gastric cancer MKN45 cells. (English) // J. Biochem. : journal. - 1997. - Vol. 121 , no. 3 . - P. 626-632 . - DOI : 10.1093 / oxfordjournals.jbchem.a021631 . - PMID 9133635 .
- Yamaguchi Y., Fujii J., Inoue S. et al. Mapping of the alpha-1,6-fucosyltransferase gene, FUT8, to human chromosome 14q24.3. (English) // Cytogenetic and Genome Research : journal. - Karger Publishers , 1999. - Vol. 84 , no. 1-2 . - P. 58-60 . - DOI : 10.1159 / 000015215 . - PMID 10343104 .
- Takahashi T., Ikeda Y., Tateishi A. et al. A sequence motif involved in the donor substrate binding by alpha1,6-fucosyltransferase: the role of the conserved arginine residues. (English) // Glycobiology: journal. - 2000. - Vol. 10 , no. 5 . - P. 503-510 . - DOI : 10.1093 / glycob / 10.5.503 . - PMID 10764839 .
- Yamaguchi Y., Ikeda Y., Takahashi T. et al. Genomic structure and promoter analysis of the human alpha1, 6-fucosyltransferase gene (FUT8). (English) // Glycobiology: journal. - 2000. - Vol. 10 , no. 6 . - P. 637-643 . - DOI : 10.1093 / glycob / 10.6.637 . - PMID 10814706 .
- Takahashi T., Ikeda Y., Miyoshi E. et al. alpha1,6fucosyltransferase is highly and specifically expressed in human ovarian serous adenocarcinomas. (English) // Int. J. Cancer : journal. - 2000. - Vol. 88 , no. 6 . - P. 914-919 . - DOI : 10.1002 / 1097-0215 (20001215) 88: 6 <914 :: AID-IJC12> 3.0.CO; 2-1 . - PMID 11093814 .
- Roos C., Kolmer M., Mattila P., Renkonen R. Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. (English) // J. Biol. Chem. : journal. - 2002. - Vol. 277 , no. 5 . - P. 3168-3175 . - DOI : 10.1074 / jbc.M107927200 . - PMID 11698403 .
- Coullin P., Crooijmans RP, Groenen MA et al. Assignment of FUT8 to chicken chromosome band 5q1.4 and to human chromosome 14q23.2 → q24.1 by in situ hybridization. Conserved and compared synteny between human and chicken. (English) // Cytogenetic and Genome Research : journal. - Karger Publishers 2003. - Vol. 97 , no. 3-4 . - P. 234-238 . - DOI : 10.1159 / 000066611 . - PMID 12438718 .
- Strausberg RL, Feingold EA, Grouse LH et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (Eng.) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 2003. - Vol. 99 , no. 26 . - P. 16899-16903 . - DOI : 10.1073 / pnas.242603899 . - PMID 12477932 .
- Martinez-Duncker I., Michalski JC, Bauvy C. et al. Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis. (English) // Glycobiology: journal. - 2004. - Vol. 14 , no. 1 . - P. 13-25 . - DOI : 10.1093 / glycob / cwh006 . - PMID 14514715 .
- Ito Y., Miyauchi A., Yoshida H. et al. Expression of alpha1,6-fucosyltransferase (FUT8) in papillary carcinoma of the thyroid: its linkage to biological aggressiveness and anaplastic transformation. (English) // Cancer Lett. : journal. - 2003. - Vol. 200 , no. 2 . - P. 167-172 . - DOI : 10.1016 / S0304-3835 (03) 00383-5 . - PMID 14568171 .