Nicotinamide mononucleotide adenylyl transferase ( eng. Nicotinamide mononucleotide adenylyltransferase ; EC 2.7.7.1) is an enzyme that catalyzes the formation of NAD + from nicotinamide mononucleotide and ATP .
| Nicotinamide mononucleotide adenylyl transferase | |
|---|---|
 | |
| Identifiers | |
| Cipher cf | 2.7.7.1 |
| CAS Number | 9032-70-6 |
| Enzyme bases | |
| Intenz | Intenz view |
| BRENDA | BRENDA entry |
| Expasy | NiceZyme view |
| Metacyc | metabolic pathway |
| Kegg | KEGG entry |
| PRIAM | profile |
| PDB structures | RCSB PDB PDBe PDBj PDBsum |
| Gene ontology | AmiGO β’ EGO |
| Search | |
| PMC | articles |
| PubMed | articles |
| NCBI | NCBI proteins |
| Cas | 9032-70-6 |
The reaction is as follows:
- ATP + nicotinamidribonucleotide diphosphate + NAD +
Content
Catalyzed Reaction
+ + PP i
Nicotinate ribonucleotide is transferred to adenosine monophosphate from ATP with the formation of deamino-NAD + and diphosphate. Nicotinamide ribonucleotide is also possible as a substrate.
Functions
A person has two farms of this group: NMNAT1 and NMNAT2 . NMNATs have a neuroprotective effect that is independent of their enzymatic activity and suggests the role of chaperone . NMNAT1 stimulates the activity of PARP-1 and binds to poly- (ADP-ribose) [1] [2] [3] .
Notes
- β Zhai RG, Zhang F., Hiesinger PR, Cao Y., Haueter CM, Bellen HJ NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration (Eng.) // Nature : journal. - 2008 .-- April ( vol. 452 , no. 7189 ). - P. 887-891 . - DOI : 10.1038 / nature06721 . - PMID 18344983 .
- β Zhai RG, Cao Y., Hiesinger PR, et al . Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity (eng.) // PLOS Biology . : journal. - 2006 .-- November ( vol. 4 , no. 12 ). - P. e416 . - DOI : 10.1371 / journal.pbio.0040416 . - PMID 17132048 .
- β Berger F., Lau C., Ziegler M. Regulation of poly (ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1 (Eng.) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 2007 .-- March ( vol. 104 , no. 10 ). - P. 3765-3770 . - DOI : 10.1073 / pnas.0609211104 . - PMID 17360427 .
Literature
- ATKINSON MR, JACKSON JF, MORTON RK Nicotinamide mononucleotide adenylyltransferase of pig-liver nuclei. The effects of nicotinamide mononucleotide concentration and pH on dinucleotide synthesis (English) // Biochemical Journal : journal. - 1961. - Vol. 80 , no. 2 . - P. 318-323 . - PMID 13684981 .
- Dahmen W., Webb B., Preiss J. The deamido-diphosphopyridine nucleotide and diphosphopyridine nucleotide pyrophosphorylases of Escherichia coli and yeast (Eng.) // Archives of Biochemistry and Biophysics : journal. - Elsevier , 1967. - Vol. 120 , no. 2 . - P. 440-450 . - DOI : 10.1016 / 0003-9861 (67) 90262-7 . - PMID 4291828 .
- Kornberg A; Pricer WE Enzymatic cleavage of diphosphopyridine nucleotide with radioactive pyrophosphate (Eng.) // Journal of Biological Chemistry : journal. - 1951. - Vol. 191 , no. 2 . - P. 535-541 . - PMID 14861199 .