IFITM1 ( Interferon-induced transmembrane protein 1 ; CD225 ) is a membrane protein from the family of interferon- induced membrane proteins, the product of the human gene IFITM1 [1] [2] .
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| , 9-27, CD225, DSPA2a, IFI17, LEU13, interferon induced transmembrane protein 1 | |||||||||||||
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In humans, the IFITM family is represented by 4 genes of the 11th chromosome : IFITM1, IFITM2, IFITM3 and IFITM5 [3] . The mouse family includes 7 proteins (there is also IFITM6 and IFITM7).
Functions
IFITM1 , like other members of this family, is an antiviral protein that inhibits the entry of the virus into the cellular cytoplasm. The protein does not affect the endocytosis of the virus, but prevents the subsequent fusion and release of the virus into the cytoplasm. Active against influenza A virus , SARS coronaviras, Marburg virus, Ebola virus , dengue virus, West Nile virus , HIV-1 and hepatitis C virus .
In addition to antiviral activity is involved in the control of cell growth and migration. It plays a key role in the antiproliferative effect of interferon-gamma due to the p53 -dependent inhibition of ERK activity and the delay of cell growth in the G1 phase. Acts as a positive regulator of osteoblast differentiation.
Notes
- ↑ Deblandre GA, Marinx OP, Evans SS, Majjaj S., Leo O., Caput D., Huez GA, Wathelet MG Explanation // J Biol Chem : journal. - 1995. - November ( vol. 270 , no. 40 ). - P. 23860–23866 . - DOI : 10.1074 / jbc.270.40.23860 . - PMID 7559564 .
- ↑ Entrez Gene: IFITM1 interferon induced transmembrane protein 1 (9-27) .
- ↑ Hickford D., Frankenberg S., Shaw G., Renfree MB Evolution of Vertebrate Interferon inducible transmembrane proteins (eng.) // BMC Genomics : journal. - 2012. - Vol. 13 - P. 155 . - DOI : 10.1186 / 1471-2164-13-155 . - PMID 22537233 .
Literature
- Bradbury LE, Kansas GS, Levy S., etal. The CD19 / CD21 signal translates the lymphocytes of the antiproliferative antibody-1 and Leu-13 molecules. (English) // J. Immunol. : journal. - 1992. - Vol. 149 , no. 9 - P. 2841-2850 . - PMID 1383329 .
- Takahashi S., Doss C., Levy S., Levy R. TAPA-1, Leu-13 antigen. (English) // J. Immunol. : journal. - 1990. - Vol. 145 , no. 7 - P. 2207-2213 . - PMID 2398277 .
- Reid LE, Brasnett AH, Gilbert CS, etal. A single DNA response element can confer inducibility of both alpha- and gamma-interferons. (Eng.) // Proceedings of the United States of America : journal. - 1989. - Vol. 86 , no. 3 - P. 840-844 . - DOI : 10.1073 / pnas.86.3.840 . - PMID 2492664 .
- Kelly JM, Gilbert CS, Stark GR, Kerr IM Differential regulation of interferon-induced mRNAs and c-myc mRNA by alpha- and gamma-interferons. (English) // Eur. J. Biochem. : journal. - 1986. - Vol. 153 , no. 2 - P. 367-371 . - DOI : 10.1111 / j.1432-1033.1985.tb09312.x . - PMID 3935435 .
- Friedman RL, Manly SP, McMahon M., etal. Transcriptional regulation of interferon-induced gene expression in human cells. (English) // Cell : journal. - Cell Press , 1984. - Vol. 38 , no. 3 - P. 745-755 . - DOI : 10.1016 / 0092-8674 (84) 90270-8 . - PMID 6548414 .
- Strausberg RL, Feingold EA, Grouse LH, etal. Human and mouse cDNA sequences. (Eng.) // Proceedings of the United States of America : journal. - 2003. - Vol. 99 , no. 26 - P. 16899-16903 . - DOI : 10.1073 / pnas.242603899 . - PMID 12477932 .
- Kita K., Sugaya S., Zhai L., etal. Human interpolation of the ray rays to X-rays. (English) // Radiat. Res. : journal. - 2003. - Vol. 160 , no. 3 - P. 302-308 . - DOI : 10.1667 / RR3039 . - PMID 12926988 .
- Lehner B., Semple JI, Brown SE, etal. The MHC class III region. (eng.) // Genomics : journal. - Academic Press , 2004. - Vol. 83 , no. 1 . - P. 153-167 . - DOI : 10.1016 / S0888-7543 (03) 00235-0 . - PMID 14667819 .
- Gerhard DS, Wagner L., Feingold EA, etal. The cIvA project: the Mammalian Gene Collection (MGC). (English) // Genome Res. : journal. - 2004. - Vol. 14 , no. 10b . - P. 2121-2127 . - DOI : 10.1101 / gr.2596504 . - PMID 15489334 .
- Akyerli CB, Beksac M., Holko M., etal. Expression of IFITM1 in chronic myeloid leukemia patients. (English) // Leuk. Res. : journal. - 2005. - Vol. 29 , no. 3 - P. 283-286 . - DOI : 10.1016 / j.leukres 2004.07.007 . - PMID 15661263 .
- Yang Y., Lee JH, Kim KY, etal. 9-27 gene modulates the interferon-inducible of natural cancer cells. (English) // Cancer Lett. : journal. - 2005. - Vol. 221 , no. 2 - P. 191-200 . - DOI : 10.1016 / j.canlet 2004.08.022 . - PMID 15808405 .
- Rual JF, Venkatesan K., Hao T., etal. Towards a proteome-scale map of the human protein-protein interaction network. (English) // Nature: journal. - 2005. - Vol. 437 , no. 7062 . - P. 1173-1178 . - DOI : 10.1038 / nature04209 . - PMID 16189514 .