Kinetochore protein NDC80 homolog ( Kinetochore protein NDC80 homolog ) is a protein of the external kinetochore region involved in cell division. The human gene product NDC80 [1] [2] [3] .
| NDC80 | |||||||||||||
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| , HEC, HEC1, HsHec1, KNTC2, TID3, hskinetochore complex component, NDC80 kinetochore complex component | |||||||||||||
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Content
- 1 Functions
- 2 Interactions
- 3 notes
- 4 Literature
Functions
Ndc80 forms a heterotetramer with proteins of the external kinetochore NUF2 , SPC25, and SPC24 . The resulting protein complex contains domains that bind to microtubules [4] . Ndc80 is involved in the signal paths of the fission spindle , which ensures error-free chromosome separation during cell division by detecting chromosomes unrelated to both poles and delaying prometaphase until all chromosomes are located in the mitotic plate [3] .
Interactions
NDC80 binds to the MIS12 , [5] [6] NEK2 [7] [8] and PSMC2 proteins . [8]
Notes
- ↑ Chen Y., Riley DJ, Chen PL, Lee WH HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis (English) // Molecular and Cellular Biology : journal. - 1997 .-- October ( vol. 17 , no. 10 ). - P. 6049-6056 . - DOI : 10.1128 / mcb.17.10.6049 . - PMID 9315664 .
- ↑ Martin-Lluesma S., Stucke VM, Nigg EA Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1 / Mad2 (Eng.) // Science: journal. - 2002 .-- September ( vol. 297 , no. 5590 ). - P. 2267-2270 . - DOI : 10.1126 / science.1075596 . - PMID 12351790 .
- ↑ 1 2 Entrez Gene: NDC80 NDC80 homolog, kinetochore complex component (S. cerevisiae) .
- ↑ D'Archivio S., Wickstead B. Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes (English) // The Journal of Cell Biology : journal. - 2017 .-- February ( vol. 216 , no. 2 ). - P. 379-391 . - DOI : 10.1083 / jcb.201608043 . - PMID 28034897 .
- ↑ Cheeseman IM, Niessen S., Anderson S., Hyndman F., Yates JR, Oegema K., Desai A. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension (Eng.) // Genes & Development : journal. - 2004 .-- September ( vol. 18 , no. 18 ). - P. 2255-2268 . - DOI : 10.1101 / gad.1234104 . - PMID 15371340 .
- ↑ Obuse C., Iwasaki O., Kiyomitsu T., Goshima G., Toyoda Y., Yanagida M. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1 (Eng.) // Nature Cell Biology : journal. - 2004 .-- November ( vol. 6 , no. 11 ). - P. 1135-1141 . - DOI : 10.1038 / ncb1187 . - PMID 15502821 .
- ↑ Chen Y., Riley DJ, Zheng L., Chen PL, Lee WH Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation // The Journal of Biological Chemistry : journal. - 2002 .-- December ( vol. 277 , no. 51 ). - P. 49408-49416 . - DOI : 10.1074 / jbc.M207069200 . - PMID 12386167 .
- ↑ 1 2 Chen Y., Sharp ZD, Lee WH HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins (Eng.) // The Journal of Biological Chemistry : journal. - 1997 .-- September ( vol. 272 , no. 38 ). - P. 24081-24087 . - DOI : 10.1074 / jbc.272.38.24081 . - PMID 9295362 .
Literature
- Chen Y., Sharp ZD, Lee WH HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins // The Journal of Biological Chemistry : journal. - 1997 .-- September ( vol. 272 , no. 38 ). - P. 24081-24087 . - DOI : 10.1074 / jbc.272.38.24081 . - PMID 9295362 .
- Zheng L., Chen Y., Lee WH Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins (Eng.) // Molecular and Cellular Biology : journal. - 1999 .-- August ( vol. 19 , no. 8 ). - P. 5417-5428 . - DOI : 10.1128 / mcb.19.8.5417 . - PMID 10409732 .
- Zheng L., Chen Y., Riley DJ, Chen PL, Lee WH Retinoblastoma protein enhances the fidelity of chromosome segregation mediated by hsHec1p (Eng.) // Molecular and Cellular Biology : journal. - 2000 .-- May ( vol. 20 , no. 10 ). - P. 3529-3537 . - DOI : 10.1128 / MCB.20.10.3529-3537.2000 . - PMID 10779342 .
- Chen Y., Riley DJ, Zheng L., Chen PL, Lee WH Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation // The Journal of Biological Chemistry : journal. - 2002 .-- December ( vol. 277 , no. 51 ). - P. 49408-49416 . - DOI : 10.1074 / jbc.M207069200 . - PMID 12386167 .
- Tien AC, Lin MH, Su LJ, Hong YR, Cheng TS, Lee YC, Lin WJ, Still IH, Huang CY Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model (Eng.) // Molecular & Cellular Proteomics : journal. - 2004 .-- January ( vol. 3 , no. 1 ). - P. 93-104 . - DOI : 10.1074 / mcp.M300072-MCP200 . - PMID 14602875 .
- DeLuca JG, Howell BJ, Canman JC, Hickey JM, Fang G., Salmon ED Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores (English) // Current Biology : journal. - Cell Press 2003 .-- December ( vol. 13 , no. 23 ). - P. 2103-2109 . - DOI : 10.1016 / j.cub.2003.10.056 . - PMID 14654001 .
- Bharadwaj R., Qi W., Yu H. Identification of two novel components of the human NDC80 kinetochore complex (Eng.) // The Journal of Biological Chemistry : journal. - 2004 .-- March ( vol. 279 , no. 13 ). - P. 13076-13085 . - DOI : 10.1074 / jbc.M310224200 . - PMID 14699129 .
- Lou Y., Yao J., Zereshki A., Dou Z., Ahmed K., Wang H., Hu J., Wang Y., Yao X. NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling (Eng.) // The Journal of Biological Chemistry : journal. - 2004 .-- May ( vol. 279 , no. 19 ). - P. 20049-20057 . - DOI : 10.1074 / jbc.M314205200 . - PMID 14978040 .
- Joseph J., Liu ST, Jablonski SA, Yen TJ, Dasso M. The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo // Current Biology : journal. - Cell Press 2004 .-- April ( vol. 14 , no. 7 ). - P. 611-617 . - DOI : 10.1016 / j.cub.2004.03.03.031 . - PMID 15062103 .
- Steensgaard P., Garrè M., Muradore I., Transidico P., Nigg EA, Kitagawa K., Earnshaw WC, Faretta M., Musacchio A. Sgt1 is required for human kinetochore assembly (eng.) // EMBO Reports : journal. - 2004 .-- June ( vol. 5 , no. 6 ). - P. 626-631 . - DOI : 10.1038 / sj.embor.7400154 . - PMID 15133482 .
- Stucke VM, Baumann C., Nigg EA Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1 (Eng.) // Chromosoma: journal. - 2004 .-- August ( vol. 113 , no. 1 ). - P. 1-15 . - DOI : 10.1007 / s00412-004-0288-2 . - PMID 15235793 .
- Meraldi P., Draviam VM, Sorger PK Timing and checkpoints in the regulation of mitotic progression (English) // Developmental Cell : journal. - 2004 .-- July ( vol. 7 , no. 1 ). - P. 45-60 . - DOI : 10.1016 / j.devcel.2004.06.06.006 . - PMID 15239953 .
- Cheeseman IM, Niessen S., Anderson S., Hyndman F., Yates JR, Oegema K., Desai A. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension (Eng.) // Genes & Development : journal. - 2004 .-- September ( vol. 18 , no. 18 ). - P. 2255-2268 . - DOI : 10.1101 / gad.1234104 . - PMID 15371340 .
- Obuse C., Iwasaki O., Kiyomitsu T., Goshima G., Toyoda Y., Yanagida M. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1 (Eng.) // Nature Cell Biology : journal. - 2004 .-- November ( vol. 6 , no. 11 ). - P. 1135-1141 . - DOI : 10.1038 / ncb1187 . - PMID 15502821 .
- Le XF, Lammayot A., Gold D., Lu Y., Mao W., Chang T., Patel A., Mills GB, Bast RC Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti -HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling // The Journal of Biological Chemistry : journal. - 2005 .-- January ( vol. 280 , no. 3 ). - P. 2092-2104 . - DOI : 10.1074 / jbc.M403080200 . - PMID 15504738 .
- DeLuca JG, Dong Y., Hergert P., Strauss J., Hickey JM, Salmon ED, McEwen BF Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites (Eng.) // Molecular Biology of the Cell : journal. - 2005 .-- February ( vol. 16 , no. 2 ). - P. 519-531 . - DOI : 10.1091 / mbc.E04-09-0852 . - PMID 15548592 .