CLEC9A ( eng. C-type lectin domain family 9 member A , C-type lectin family 9 member A; CD370) is a membrane protein expressed on a subtype of dendritic cells and monocytes . The human gene product CLEC9A [1] .
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| , DNGR1, UNQ9341, CD370, DNGR-1, C-type lectin domain family 9 member A, C-type lectin domain containing 9A | |||||||||||||
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Content
Functions
It is a membrane protein of the class C lectin , part of group V. Expressed on myeloid cells. It functions as an endocytosis receptor on a small subtype of myeloid cells specializing in the capture and processing of dead cell material. Recognizes the filament form of actin associated with the actin-binding domains of cytoskeletal proteins, including spectrin , exposed to the extracellular medium in case of cell damage. Mediates SYK- dependent cross-presentation of antigens associated with dead cells.
Structure
CLEC9A consists of 241 amino acids , a molecular weight of 27.3 kDa. Contains a type C lectin domain and an activating ITAM-like motif.
Tissue specificity
The protein is expressed in peripheral blood on the surface of BDCA31 + dendritic cells and on the CD14 + / CD16 monocyte subtype.
Notes
- ↑ Entrez Gene: C-type lectin domain family 9 member A . Date of treatment June 2, 2016.
Literature
- Huysamen C., Willment JA, Dennehy KM, Brown GD CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3 + dendritic cells and a subset of monocytes (Eng.) // J. Biol. Chem. : journal. - 2008 .-- Vol. 283 , no. 24 . - P. 16693-16701 . - DOI : 10.1074 / jbc.M709923200 . - PMID 18408006 .