Membrane glycoprotein OX-2 ( Eng. OX-2 membrane glycoprotein ; CD200) is a membrane protein of the immunoglobulin superfamily, a product of the CD200 gene [1] [2] . It is a ligand for the CD200R1 receptor.
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Content
- 1 Functions
- 2 Structure
- 3 notes
- 4 Literature
Functions
CD200 is a type 1 membrane protein, contains two immunoglobulin domains. Co-stimulator of T-lymphocyte proliferation . It possibly regulates the activity of myeloid cells and delivers an inhibitory signal to macrophage cells in various tissues.
Structure
CD200 includes 278 amino acids , a molecular weight of 31.2 kDa. Contains one transmembram fragment. The extracellular domain contains two immunoglobulin domains of V - and C2 type. Alternative splicing leads to the formation of several protein isoforms [2] .
Notes
- ↑ P41217 (OX2G_HUMAN) (unspecified . Uniprot Date of appeal May 16, 2013.
- ↑ 1 2 Entrez Gene: CD200 CD200 molecule .
Literature
- Gorczynski RM Evidence for an immunoregulatory role of OX2 with its counter ligand (OX2L) in the regulation of transplant rejection, fetal loss, autoimmunity and tumor growth (Eng.) // Arch. Immunol. Ther. Exp. (Warsz.): Journal. - 2002. - Vol. 49 , no. 4 . - P. 303-309 . - PMID 11726033 .
- Douglas J., Albertson DG, Barclay AN et al. RFLP and mapping of human MOX-1 gene on chromosome 3 (Eng.) // Nucleic Acids Res. : journal. - 1988. - Vol. 16 , no. 18 . - P. 9067 . - DOI : 10.1093 / nar / 16.18.9067 . - PMID 2902568 .
- McCaughan GW, Clark MJ, Barclay AN Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein (Eng.) // Immunogenetics: journal. - 1987. - Vol. 25 , no. 5 . - P. 329-335 . - DOI : 10.1007 / BF00404426 . - PMID 3032785 .
- Wright GJ, Puklavec MJ, Willis AC et al. Lymphoid / neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function (English) // Immunity: journal. - Cell Press , 2000. - Vol. 13 , no. 2 . - P. 233-242 . - DOI : 10.1016 / S1074-7613 (00) 00023-6 . - PMID 10981966 .
- Hoek RM, Ruuls SR, Murphy CA et al. Down-regulation of the macrophage lineage through interaction with OX2 (CD200) (Eng.) // Science: journal. - 2000. - Vol. 290 , no. 5497 . - P. 1768-1771 . - DOI : 10.1126 / science.290.5497.1768 . - PMID 11099416 .
- Wright GJ, Jones M., Puklavec MJ et al. The unusual distribution of the neuronal / lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans (Eng.) // Immunology: journal. - 2001. - Vol. 102 , no. 2 . - P. 173-179 . - DOI : 10.1046 / j.1365-2567.2001.01163.x . - PMID 11260322 .
- Strausberg RL, Feingold EA, Grouse LH et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences (Eng.) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 2003. - Vol. 99 , no. 26 . - P. 16899-16903 . - DOI : 10.1073 / pnas.242603899 . - PMID 12477932 .
- Wright GJ, Cherwinski H., Foster-Cuevas M. et al. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200 (Eng.) // J. Immunol. : journal. - 2003. - Vol. 171 , no. 6 . - P. 3034-3046 . - DOI : 10.4049 / jimmunol . 171.6.3034 . - PMID 12960329 .
- Gerhard DS, Wagner L., Feingold EA et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) (Eng.) // Genome Res. : journal. - 2004. - Vol. 14 , no. 10B . - P. 2121-2127 . - DOI : 10.1101 / gr.2596504 . - PMID 15489334 .
- Chen DX, Gorczynski RM Discrete monoclonal antibodies define functionally important epitopes in the CD200 molecule responsible for immunosuppression function (neopr.) // Transplantation. - 2005. - T. 79 , No. 3 . - S. 282-288 . - DOI : 10.1097 / 01.TP.0000149506.61000.86 . - PMID 15699757 .
- Chen Z., Marsden PA, Gorczynski RM Cloning and characterization of the human CD200 promoter region (Eng.) // Mol. Immunol. : journal. - 2006. - Vol. 43 , no. 6 . - P. 579-587 . - DOI : 10.1016 / j.molimm.2005.04.014 . - PMID 15955564 .
- Shiratori I., Yamaguchi M., Suzukawa M. et al. Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200 (Eng.) // J. Immunol. : journal. - 2005. - Vol. 175 , no. 7 . - P. 4441-4449 . - DOI : 10.4049 / jimmunol . 175.7.4441 . - PMID 16177086 .
- Otsuki T., Ota T., Nishikawa T. et al. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries (Eng.) // DNA Res. : journal. - 2007. - Vol. 12 , no. 2 . - P. 117-126 . - DOI : 10.1093 / dnares / 12.2.117 . - PMID 16303743 .
- Kimura K., Wakamatsu A., Suzuki Y. et al. Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes // Russian Genome Res. : journal. - 2006. - Vol. 16 , no. 1 . - P. 55-65 . - DOI : 10.1101 / gr.4039406 . - PMID 16344560 .
- Matsue H. CD 200-mediated regulation of skin immunity // J. Invest. Dermatol. : journal. - 2006. - Vol. 125 , no. 6 . - P. x — xi . - DOI : 10.1111 / j.0022-202X.2005.23978.x . - PMID 16354172 .