William Prichard ( born William W. Prichard ; 1914 , Tief River Falls , Minnesota - March 30, 2013 , Wilmington ) - American pharmacologist, creator of the antiviral drug rimantadine .
He graduated from the University of Minnesota , where he defended his dissertation in organic chemistry in 1939, after which he joined the DuPont Central Research Laboratory in Wilmington. He worked there until 1979, having retired to care for his sick wife.
The most important of Prichard’s achievements is rimantadine [1] obtained in 1963 and patented in the USA in 1965 [1] , which was the result of the study of amantadine derivatives (patents for the chemical formula US Patent 3,552,912 , 1965 and the synthesis method US Patent 3,592,934 , 1967) [2] [3] [4] . The synthesis methods proposed by Pritchard were based on the preparation of rimantadine from ketoxime by reduction with lithium aluminum hydride .
Notes
- ↑ US Patent No. 3352912 for a New Derivative of Amantadine (WW Prichard)
- ↑ United States Patent No. 4551552: Process for preparing rimantadine : “ Rimantadine and related compounds useful as antivirals were first described by Prichard in US Pat. Nos. 3,352,912 and 3,592,934. Both patents describe the preparation of rimantadine from the corresponding ketone oxime by reduction with lithium aluminum hydride . "
- ↑ Rimantadine
- ↑ DM Zlydnikov, OI Kubar, TP Kovaleva, LE Kamforin. Study of Rimantadine in the USSR: A Review of the Literature. Clinical Infectious Diseases 3: 408-421, p. 408: “ The promising results obtained with amantadine and the encouragement of Academician AA Smorodintsev, led, in 1969, to the initiation of investigations of the new American derivative, rimantadine (Du Pont & Co ., Wilmington, Del.) . "