CDCP1 ( English CUB domain-containing protein 1 , a protein containing CUB- domain; CD318 ) is a membrane protein , regulator of cell adhesion. The human gene product CDCP1 [1] [2] .
CDCP1 | ||||||
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, CD318, SIMA135, TRASK, CUB domain containing protein 1 | ||||||
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Content
Functions
CDCP1 / Trask is a transmembrane glycoprotein, molecular weight 140 kDa. The protein contains a large extracellular domain with two CUB domains and an intracellular domain with 5 tyrosines . Phosphorylation of tyrosine protein is closely related to the regulation of the state of cell adhesion [3] . In cell culture, CDCP1 phosphorylation is associated with the process of separating cells from the substrate during trypsin or EDTA treatment, as well as during mitotic separation. A particularly high level of CDCP1 expression is found in epithelial cells in which protein phosphorylation occurs during mitotic cell separation or in a detached phenotype. Thus, phosphorylation of CDCP1 is inversely correlated with the state of cell attachment.
It is phosphorylated by the SRC family of tyrosine kinases , including SRC and YES, as well as protein kinase C-gamma / PRKCG.
Clinical value
CDCP1 phosphorylation is found in many cancer cells, including some premetastatic cancers, as well as in metastatic cells and in metastases [4] .
Notes
- ↑ Scherl-Mostageer M., Sommergruber W., Abseher R., Hauptmann R., Ambros P., Schweifer N. Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer (English) // Oncogene : journal. - 2001. - July ( vol. 20 , no. 32 ). - P. 4402-4408 . - DOI : 10.1038 / sj.onc.1204566 . - PMID 11466621 .
- ↑ Entrez Gene: CDCP1 CUB domain containing protein 1 .
- ↑ Spassov DS, Ahuja D., Wong CH, Moasser MM (PL ) // PLoS One : journal. - 2011. - Vol. 6 , no. 4 - P. e19154 . - DOI : 10.1371 / journal.pone.0019154 . - PMID 21559459 .
- ↑ Wortmann A., He Y., Deryugina EI, Quigley JP, Hooper JD The cell surface glycoprotein CDCP1 in cancer - insights, opportunities, and challenges (eng.) // IUBMB Life: journal. - 2009. - July ( vol. 61 , no. 7 ). - P. 723-730 . - DOI : 10.1002 / iub.198 . - PMID 19514048 .
Literature
- Xia Y., Gil SG, Carter WG Anchorage mediated by integrin regulates membrane-associated 80-kD protein (Eng.) // The Journal of Cell Biology : journal. - 1996. - February ( vol. 132 , no. 4 ). - P. 727-740 . - DOI : 10.1083 / jcb.132.4.727 . - PMID 8647901 .
- Hooper JD, Zijlstra A., Aimes RT, Liang H., Claassen GF, Tarin D., Testa JE, Quigley JP Subtractive immunization SIMA135 / CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen (English). ) // Oncogene : journal. - 2003. - March ( vol. 22 , no. 12 ). - P. 1783-1794 . - DOI : 10.1038 / sj.onc.1206220 . - PMID 12660814 .
- Conze T., Lammers R., Kuci S., Scherl-Mostageer M., Schweifer N., Kanz L., Buhring HJ CDCP1 is a novel marker for hematopoietic stem cells (eng.) // Annals of the New York Academy of Sciences : journal. - 2003. - May ( vol. 996 , no. 1 ). - P. 222-226 . - DOI : 10.1111 / j.1749-6632.2003.tb03249.x . - PMID 12799299 .
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- Brown TA, Yang TM, Zaitsevskaia T., Xia Y., Dunn CA, Sigle RO, Knudsen B., Carter WG ( in epithelia ) English) // The Journal of Biological Chemistry : journal. - 2004. - April ( vol. 279 , no. 15 ). P. 14772-14783 . - DOI : 10.1074 / jbc.M309678200 . - PMID 14739293 .
- Bühring HJ, Kuçi S., Conze T., Rathke G., Bartolović K., Grünebach F., Scherl-Mostageer M., Brümmendorf TH, Schweifer N., Lammers R. CDCP1 identifies a broad spectrum of normal and malignant stem / progenitor cell subsets of hematopoietic and nonhematopoietic origin (English) // Stem Cells: journal. - 2005. - Vol. 22 , no. 3 - P. 334-343 . - DOI : 10.1634 / stemcells.22-3-334 . - PMID 15153610 .
- Benes CH, Wu N., Elia AE, Dharia T., Cantley LC, Soltoff SP The C2 domain of PKCdelta is a phosphotyrosine binding domain (Eng.) // Cell : journal. - Cell Press , 2005. - April ( vol. 121 , no. 2 ). - P. 271-280 . - DOI : 10.1016 / j.cell.2005.02.019 . - PMID 15851033 .
- Bhatt AS, Erdjument-Bromage H., Tempst P., Craik CS, Moasser MM Ad hoc signaling of the src kinases (eng.) // Oncogene : journal. - 2005. - August ( vol. 24 , no. 34 ). - P. 5333–5343 . - DOI : 10.1038 / sj.onc.1208582 . - PMID 16007225 .
- André M., Le Caer JP, Greco C., Planchon S., El Nemer W., Boucheix C., Rubinstein E., Chamot-Rooke J., Le Naour F. Protect analysis of the tetraspanin web using LC-ESI- MS / MS and MALDI-FTICR-MS (English) // Proteomics: journal. - 2006. - March ( vol. 6 , no. 5 ). P. 1437-1449 . - DOI : 10.1002 / pmic.200500180 . - PMID 16404722 .
- Kimura H., Morii E., Ikeda JI, Ezoe S., Xu JX, Nakamichi N., Tomita Y., Shibayama H., Kanakura Y., Aozasa K. CDRL1 in hematopoietic cells (English) // Leukemia: journal. - 2006. - September ( vol. 20 , no. 9 ). - P. 1551—1556 . - DOI : 10.1038 / sj.leu.2404312 . - PMID 16926850 .
- Perry, SE, Robinson, P., Melcher, A., Quirke, P., Bühring, HJ, Cook GP, and Blair GE (CDCP1) gene in colorectal tumors (Eng.) // FEBS Letters : journal. - 2007. - March ( vol. 581 , no. 6 ). - P. 1137-1142 . - DOI : 10.1016 / j.febslet.2007.02.02.025 . - PMID 17335815 .
- Uekita T., Jia L., Narisawa-Saito M., Yokota J., Kiyono T., Sakai R. CUB domain-containing protein 1 is a modercular and Cellular Biology : journal. - 2007. - November ( vol. 27 , no. 21 ). - P. 7649-7660 . - DOI : 10.1128 / MCB.01246-07 . - PMID 17785447 .