Estrone (E1) - female sex hormone , the second most important after estradiol , estrogen . It is produced by the follicular apparatus of the ovaries in women .
| Estron | |
|---|---|
 | |
 | |
| Are common | |
| Systematic name | 1,3,5-estratrien-3-ol-17-one |
| Chem. formula | C 18 H 22 O 2 |
| Classification | |
| Reg. CAS number | |
| PubChem | |
| Reg. EINECS number | |
| Smiles | |
| Inchi | |
| Chebi | |
| ChemSpider | |
Small amounts of estrone are also produced by the adrenal cortex in both sexes and the testes in men . According to the chemical structure, estrone is a steroid hormone .
Estron is synthesized from androstenedione and progesterone derivatives. The conversion consists in demethylating C19 and restoring the aromaticity of the A-cycle. The reaction is similar to the conversion of testosterone to estradiol
Estradiol is able to convert in the liver and in peripheral tissues to estrone and vice versa. Estron is less active than estradiol, 4-5 times. There are suggestions that the physiological role of estradiol and estrone may be different, due to the fact that they are not equally associated with estrogen receptors of subtypes E1 and E2.