Platelet glycoprotein V ( Eng. Glycoprotein V ; GP5; CD42d) is a membrane protein , a product of the human gene GP5 [1] .
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Functions
Glycoprotein V (GP5) is included in the receptor complex of glycoprotein Ib-IX-V along with the alpha and beta chains of glycoprotein Ib and glycoprotein IX . The complex functions as a von Willebrand factor receptor and is involved in platelet adhesion to the damaged surface of arteries, a critical initial stage of hemostasis [1] .
Structure
Glycoprotein V, a transmembrane protein, consists of 544 amino acids, the extracellular domain contains 8 N-glycosylation sites at asparagine residues.
Notes
Literature
- Modderman PW, Admiraal LG, Sonnenberg A., von dem Borne AE Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane. (English) // J. Biol. Chem. : journal. - 1992. - Vol. 267 , no. 1 . - P. 364-369 . - PMID 1730602 .
- Shimomura T., Fujimura K., Maehama S. et al. Rapid purification and characterization of human platelet glycoprotein V: the amino acid sequence contains leucine-rich repetitive modules as in glycoprotein Ib. (Eng.) // Blood : journal. - American Society of Hematology 1990. - Vol. 75 , no. 12 . - P. 2349-2356 . - PMID 2350580 .
- Roth GJ, Church TA, McMullen BA, Williams SA Human platelet glycoprotein V: a surface leucine-rich glycoprotein related to adhesion. (English) // Biochem. Biophys. Res. Commun. : journal. - 1990. - Vol. 170 , no. 1 . - P. 153-161 . - DOI : 10.1016 / 0006-291X (90) 91253-O . - PMID 2372284 .
- Hickey MJ, Hagen FS, Yagi M., Roth GJ Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins. (Eng.) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 1993. - Vol. 90 , no. 18 . - P. 8327-8331 . - DOI : 10.1073 / pnas.90.18.8327 . - PMID 7690959 .
- Meyer SC, Fox JE Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von Willebrand factor to glycoprotein Ib-IX in transfected cells. (English) // J. Biol. Chem. : journal. - 1995. - Vol. 270 , no. 24 . - P. 14693-14699 . - DOI : 10.1074 / jbc.270.24.14693 . - PMID 7782333 .
- Takafuta T., Fujimura K., Kawano H. et al. Expression of platelet membrane glycoprotein V in human megakaryocytes and megakaryocytic cell lines: a study using a novel monoclonal antibody against GPV. (English) // Thromb. Haemost. : journal. - 1995. - Vol. 72 , no. 5 . - P. 762-769 . - PMID 7900083 .
- Lanza F., Morales M., de La Salle C. et al. Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation. (English) // J. Biol. Chem. : journal. - 1993. - Vol. 268 , no. 28 . - P. 20801-20807 . - PMID 8407908 .
- Yagi M., Edelhoff S., Disteche CM, Roth GJ Human platelet glycoproteins V and IX: mapping of two leucine-rich glycoprotein genes to chromosome 3 and analysis of structures. (English) // Biochemistry: journal. - 1996. - Vol. 34 , no. 49 . - P. 16132-16137 . - DOI : 10.1021 / bi00049a028 . - PMID 8519770 .
- Berger G., Massé JM, Cramer EM Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V. (English) // Blood : journal. - American Society of Hematology 1996. - Vol. 87 , no. 4 . - P. 1385-1395 . - PMID 8608228 .
- Ravanat C., Morales M., Azorsa DO et al. Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage. (Eng.) // Blood : journal. - American Society of Hematology 1997. - Vol. 89 , no. 9 . - P. 3253-3262 . - PMID 9129030 .
- Bradford HN, Dela Cadena RA, Kunapuli SP et al. Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex. (Eng.) // Blood : journal. - American Society of Hematology 1997. - Vol. 90 , no. 4 . - P. 1508-1515 . - PMID 9269768 .
- Wu G., Essex DW, Meloni FJ et al. Human endothelial cells in culture and in vivo express on their surface all four components of the glycoprotein Ib / IX / V complex. (Eng.) // Blood : journal. - American Society of Hematology 1997. - Vol. 90 , no. 7 . - P. 2660-2669 . - PMID 9326233 .
- Andrews RK, Harris SJ, McNally T., Berndt MC Binding of purified 14-3-3 zeta signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex. (English) // Biochemistry: journal. - 1998. - Vol. 37 , no. 2 . - P. 638-647 . - DOI : 10.1021 / bi970893g . - PMID 9425086 .
- Longhurst CM, White MM, Wilkinson DA, Jennings LK A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb / V / IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states. (English) // Eur. J. Biochem. : journal. - 1999. - Vol. 263 , no. 1 . - P. 104-111 . - DOI : 10.1046 / j.1432-1327.1999.00467.x . - PMID 10429193 .
- Dicker IB, Pedicord DL, Seiffert DA et al. Both the high affinity thrombin receptor (GPIb-IX-V) and GPIIb / IIIa are implicated in expression of thrombin-induced platelet procoagulant activity. (English) // Thromb. Haemost. : journal. - 2002. - Vol. 86 , no. 4 . - P. 1065-1069 . - PMID 11686325 .
- Rabie T., Strehl A., Ludwig A., Nieswandt B. Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V. (Eng.) // J. Biol. Chem. : journal. - 2005. - Vol. 280 , no. 15 . - P. 14462-14468 . - DOI : 10.1074 / jbc.M500041200 . - PMID 15691827 .
- Aktas B., Pozgajova M., Bergmeier W. et al. Aspirin induces platelet receptor shedding via ADAM17 (TACE). (English) // J. Biol. Chem. : journal. - 2006. - Vol. 280 , no. 48 . - P. 39716-39722 . - DOI : 10.1074 / jbc.M507762200 . - PMID 16179345 .
- Lewandrowski U., Moebius J., Walter U., Sickmann A. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (English) // Mol. Cell. Proteomics : journal. - 2006. - Vol. 5 , no. 2 . - P. 226-233 . - DOI : 10.1074 / mcp.M500324-MCP200 . - PMID 16263699 .