Grineva Nina Ivanovna ( December 27, 1927 , Moscow - August 10, 2018 , ibid.) - Soviet and Russian scientist in the field of molecular biology and bioorganic chemistry , doctor of chemical sciences, professor. Researcher in the field of methods of treating oncological diseases of the blood system based on directed inactivation of oncogenes using alkylating oligonucleotide derivatives. Laureate of the Lenin Prize (1990) together with prof. D. G. Knorre .
| Grineva Nina Ivanovna | |
|---|---|
 | |
| Date of Birth | December 27, 1927 |
| Place of Birth | Moscow , USSR |
| Date of death | August 10, 2018 (90 years old) |
| A place of death | Moscow , Russia |
| Scientific field | bioorganic chemistry , oncology |
| Place of work | NIOC , National Medical Research Center for Hematology |
| Alma mater | MKHTI them. D.I. Mendeleev |
| Academic degree | Doctor of Chemical Sciences |
| supervisor | D. G. Knorre |
| Known as | the use of antisense oligonucleotides for DNA modification |
| Awards and prizes |  |
Biography
Born December 27, 1927 in a family of military doctors.
In 1945 she entered the Moscow Institute of Chemical Technology. D. I. Mendeleeva , after which from 1949 to 1962 she worked at the Research Institute of Organic Intermediates and Dyes , at which she completed graduate school and defended her thesis.
In 1962 she moved to the Novosibirsk Academgorodok and until 1975 worked under the direction of Academician D. G. Knorre in the Laboratory of Nucleic Acid Chemistry of the Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the USSR Academy of Sciences .
In 1967, in the Tetrahedron Lett magazine, together with A. M. Belikova and V. F. Zarytova, she published a pioneer work in which the possibility of applying the principle of complementary nucleic acid interaction for targeted DNA modification of PMID 6073336 was formulated and practically proved. In this work, it was proposed to use oligonucleotides complementary to them carrying chemically active radicals for targeted action on genes. [1] [2] In 1978, P. Mark (USA) showed that a synthetic oligonucleotide that is complementary to a specific region of viral RNA inhibits the development of the virus in living cells, these works are considered the basis of antisense technologies [3] .
In 1975, she was invited to work in Moscow at the Hematology Research Center. In 1978, she organized a laboratory of genetic engineering at the Scientific and Research Center for Hematology , which she headed until 2004 [4] .
Rewards
- Laureate of the Lenin Prize together with D. G. Knorre , R. I. Salganik , Z. A. Shabarova (1990) [5]
Notes
- ↑ Scientific Russia: DNA Decoders
- ↑ Science in Siberia // N 45-46 (2181–2182) December 4, 1998 HIGH-PRECISION WEAPON AGAINST VIRUSES
- ↑ https://scfh.ru/papers/novye-analogi-dnk-dlya-lecheniya-nasledstvennykh-bolezney/ First-hand Science: Oct 11, 2017, Russia Makes Itself, Volume 75, No. 4 // New DNA analogues for treatment hereditary and infectious diseases
- ↑ Laboratory of Genetic Engineering NMIC Hematology
- ↑ http://www.niboch.nsc.ru/doku.php/ru/science/achievements Creating the foundations of targeted modification of genetic structures