Neuropilin 2 ( Eng. Neuropilin 2 , NRP2) is a membrane protein expressed in neurons , the product of the NRP2 gene [1] [2] . Protein of the neuropilin family.
| Neuropilin 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | |||||||||||||
| |||||||||||||
| Identifiers | |||||||||||||
| , NP2, NPN2, PRO2714, VEGF165R2, neuropilin 2 | |||||||||||||
| External IDs | |||||||||||||
| |||||||||||||
| RNA expression profile | |||||||||||||
  | |||||||||||||
| Orthologists | |||||||||||||
| Kinds | Person | Mouse | |||||||||||
| Entrez | |||||||||||||
| Ensembl | |||||||||||||
| Uniprot | |||||||||||||
| RefSeq (mRNA) | |||||||||||||
| RefSeq (protein) | |||||||||||||
| Locus (UCSC) | |||||||||||||
| PubMed Search | |||||||||||||
| Wikidata | |||||||||||||
| View / Edit (Man) | View / Edit (Mouse) | ||||||||||||
Functions
Neuropilin 2 is a membrane receptor for the neuropilin family. It binds to semaphorins SEMA3C and SEMA3F and to vascular endothelial growth factor ( VEGF ). Protein plays a role in the development of the cardiovascular system, directed axon growth and tumorigenesis [3] .
Structure
Neuropilin 2 consists of 911 amino acids , contains 4 glycosylation sites, 6 disulfide bonds. Alternative splicing generates 6 isoforms. The extracellular domain contains 2 CUB domains and F5 / 8 C-type domains. CUB domains are involved in the binding of semaphorins, F5 / 8 C-type domains are responsible for the binding of heparin and VEGF.
Interactions
Neuropilin 2 binds to semaphorins 3C, 3F, VEGF-A isoforms of VEGF- 165 and VEGF-145, and isoform of placental growth factor ( PGF ) PLGF-2.
See also
- Neuropilin 1
Notes
- ↑ Soker S., Takashima S., Miao HQ, Neufeld G., Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor (Eng.) // Cell : journal. - Cell Press 1998 .-- April ( vol. 92 , no. 6 ). - P. 735-745 . - DOI : 10.1016 / S0092-8674 (00) 81402-6 . - PMID 9529250 .
- ↑ Chen H., Chedotal A., He Z., Goodman CS, Tessier-Lavigne M. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III (English) // Neuron : journal. - Cell Press 1997 .-- November ( vol. 19 , no. 3 ). - P. 547–559 . - DOI : 10.1016 / S0896-6273 (00) 80371-2 . - PMID 9331348 .
- ↑ Entrez Gene: NRP2 neuropilin 2 .
Literature
- Neufeld G., Cohen T., Gengrinovitch S., Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. (Eng.) // The FASEB Journal : journal. - Federation of American Societies for Experimental Biology , 1999. - Vol. 13 , no. 1 . - P. 9-22 . - PMID 9872925 .
- Kolodkin AL, Levengood DV, Rowe EG, etal. Neuropilin is a semaphorin III receptor. (English) // Cell . - Cell Press 1997. - Vol. 90 , no. 4 . - P. 753-762 . - DOI : 10.1016 / S0092-8674 (00) 80535-8 . - PMID 9288754 .
- Giger RJ, Urquhart ER, Gillespie SK, etal. Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity. (English) // Neuron : journal. - Cell Press , 1999. - Vol. 21 , no. 5 . - P. 1079-1092 . - DOI : 10.1016 / S0896-6273 (00) 80625-X . - PMID 9856463 .
- Chen H., He Z., Bagri A., Tessier-Lavigne M. Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins. (English) // Neuron : journal. - Cell Press , 1999. - Vol. 21 , no. 6 . - P. 1283-1290 . - DOI : 10.1016 / S0896-6273 (00) 80648-0 . - PMID 9883722 .
- Takahashi T., Nakamura F., Jin Z., etal. Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors. (Eng.) // Nat. Neurosci. : journal. - 1999. - Vol. 1 , no. 6 . - P. 487-493 . - DOI : 10.1038 / 2203 . - PMID 10196546 .
- Rossignol M., Beggs AH, Pierce EA, Klagsbrun M. Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively. (English) // Genomics : journal. - Academic Press , 1999. - Vol. 57 , no. 3 . - P. 459-460 . - DOI : 10.1006 / geno.1999.5790 . - PMID 10329017 .
- Tamagnone L., Artigiani S., Chen H., etal. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. (English) // Cell : journal. - Cell Press , 1999. - Vol. 99 , no. 1 . - P. 71-80 . - DOI : 10.1016 / S0092-8674 (00) 80063-X . - PMID 10520995 .
- Gluzman-Poltorak Z., Cohen T., Herzog Y., Neufeld G. Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]. (English) // J. Biol. Chem. : journal. - 2000. - Vol. 275 , no. 24 . - P. 18040-18045 . - DOI : 10.1074 / jbc.M909259199 . - PMID 10748121 .
- Handa A., Tokunaga T., Tsuchida T., etal. Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. (English) // Int. J. Oncol. : journal. - 2000. - Vol. 17 , no. 2 . - P. 291-295 . - DOI : 10.3892 / ijo.17.2.291 . - PMID 10891538 .
- Rossignol M., Gagnon ML, Klagsbrun M. Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms. (English) // Genomics : journal. - Academic Press , 2001. - Vol. 70 , no. 2 . - P. 211-222 . - DOI : 10.1006 / geno.2000.6381 . - PMID 11112349 .
- Gluzman-Poltorak Z., Cohen T., Shibuya M., Neufeld G. Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes. (English) // J. Biol. Chem. : journal. - 2001. - Vol. 276 , no. 22 . - P. 18688-18694 . - DOI : 10.1074 / jbc.M006909200 . - PMID 11278319 .
- Cohen T., Gluzman-Poltorak Z., Brodzky A., etal. Neuroendocrine cells along the digestive tract express neuropilin-2. (English) // Biochem. Biophys. Res. Commun. : journal. - 2001. - Vol. 284 , no. 2 . - P. 395-403 . - DOI : 10.1006 / bbrc.2001.4958 . - PMID 11394892 .
- Herzog Y., Kalcheim C., Kahane N., etal. Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins. (English) // Mech. Dev. : journal. - 2002. - Vol. 109 , no. 1 . - P. 115-119 . - DOI : 10.1016 / S0925-4773 (01) 00518-4 . - PMID 11677062 .
- Oh H., Takagi H., Otani A., etal. Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis. (Eng.) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 2002. - Vol. 99 , no. 1 . - P. 383-388 . - DOI : 10.1073 / pnas.012074399 . - PMID 11756651 .
- Fakhari M., Pullirsch D., Abraham D., etal. Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma. (English) // Cancer : journal. - Wiley-Blackwell , 2002. - Vol. 94 , no. 1 . - P. 258-263 . - DOI : 10.1002 / cncr . 10177 . - PMID 11815985 .
- Cohen T., Herzog Y., Brodzky A., etal. Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumors. (English) // J. Pathol. : journal. - 2002. - Vol. 198 , no. 1 . - P. 77-82 . - DOI : 10.1002 / path.1179 . - PMID 12210066 .
- Kawakami T., Tokunaga T., Hatanaka H., etal. Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma. (English) // Cancer : journal. - Wiley-Blackwell 2003. - Vol. 95 , no. 10 . - P. 2196-2201 . - DOI : 10.1002 / cncr.10936 . - PMID 12412174 .
- Strausberg RL, Feingold EA, Grouse LH, etal. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (Eng.) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 2003. - Vol. 99 , no. 26 . - P. 16899-16903 . - DOI : 10.1073 / pnas.242603899 . - PMID 12477932 .