Frizzled-10 (FZ-10, CD350) is a membrane protein from the G-protein coupled receptor family. Human gene product FZD10 . [1] [2] Refers to the Frizzled receptor group.
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| , CD350, FZ-10, Fz10, FzE7, hFz10, frizzled class receptor 10 | |||||||||||||
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Content
- 1 Functions
- 2 Tissue specificity
- 3 Interactions
- 4 notes
- 5 Literature
Functions
Membrane protein FZ-10 belongs to the Frizzled family of G-protein-coupled superfamilies . Frizzled are Wnt signaling protein receptors and are associated with the canonical beta-catenin signaling pathway. FZD9 may be involved in the regulation of cell polarity during morphogenesis and tissue differentiation.
Tissue specificity
The highest level of expression was found in the placenta and fetal kidneys, as well as in the fetal lungs and brain. In adult brains, high expression is localized in the cerebellum, as well as in the cerebral cortex, medulla oblongata, and spinal cord. Low levels of protein are found in the brain, heart, lungs, skeletal muscles, pancreas, spleen and prostate gland.
Interactions
Interacts with WNT7B and myocilin .
Notes
- ↑ Koike J., Takagi A., Miwa T., Hirai M., Terada M., Katoh M. Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family (Eng.) // Biochemical and Biophysical Research Communications : journal. - 1999 .-- August ( vol. 262 , no. 1 ). - P. 39-43 . - DOI : 10.1006 / bbrc.1999.1161 . - PMID 10448064 .
- ↑ Entrez Gene: FZD10 frizzled homolog 10 (Drosophila) .
Literature
- Finch PW, He X., Kelley MJ, Uren A., Schaudies RP, Popescu NC, Rudikoff S., Aaronson SA, Varmus HE, Rubin JS Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action ) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 1997 .-- June ( vol. 94 , no. 13 ). - P. 6770-6775 . - DOI : 10.1073 / pnas.94.13.6770 . - PMID 9192640 .
- Tanaka S., Akiyoshi T., Mori M., Wands JR, Sugimachi K. A novel frizzled gene identified in human esophageal carcinoma mediates APC / beta-catenin signals (Eng.) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 1998 .-- August ( vol. 95 , no. 17 ). - P. 10164-10169 . - DOI : 10.1073 / pnas.95.17.10164 . - PMID 9707618 .
- Kumar S., Connor JR, Dodds RA, Halsey W., Van Horn M., Mao J., Sathe G., Mui P., Agarwal P., Badger AM, Lee JC, Gowen M., Lark MW Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries (Eng.) // Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society : journal. - 2001 .-- October ( vol. 9 , no. 7 ). - P. 641-653 . - DOI : 10.1053 / joca.2001.0421 . - PMID 11597177 .
- Terasaki H., Saitoh T., Shiokawa K., Katoh M. Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway (Eng.) // International Journal of Molecular Medicine : journal. - 2002 .-- February ( vol. 9 , no. 2 ). - P. 107-112 . - DOI : 10.3892 / ijmm.9.2.107 . - PMID 11786918 .
- Omoto S., Hayashi T., Kitahara K., Takeuchi T., Ueoka Y. Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R ) // Ophthalmic Genetics: journal. - 2004 .-- June ( vol. 25 , no. 2 ). - P. 81-90 . - DOI : 10.1080 / 13816810490514270 . - PMID 15370539 .