Frizzled-9 (CD349) is a membrane protein from the G protein coupled receptor family. Human gene product FZD9 . [1] [2] [3] Refers to the Frizzled receptor group.
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Content
Functions
Membrane protein FZD9 belongs to the Frizzled family of G-protein-coupled superfamilies . Frizzled proteins are receptors for Wnt signaling proteins and are associated with the canonical beta-catenin signaling pathway. FZD9 is a receptor for WNT2 and is associated with the canonical beta-catenin signaling pathway, which leads to activation of the Dishevelled protein group (Dsh), inhibition of GSK-3 kinase, accumulation of beta-catenin in the nucleus and activation of Wnt-dependent genes. It plays a role in the formation of the neuromuscular synapse by negatively regulating the clustering of acetylcholine receptors mediated by the canonical beta-catenin signaling pathway. Controls bone formation mediated by ISG15 . participates in the positive regulation of bone regeneration.
Tissue specificity
Expressed mainly in the brain, testes, eyes, skeletal muscles and kidneys. [3]
Pathology
With a gene deletion, heterozygotes develop Williams syndrome .
Notes
- ↑ Wang YK, Samos CH, Peoples R., Pérez-Jurado LA, Nusse R., Francke U. A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23 .) // Human Molecular Genetics : journal. - Oxford University Press , 1997 .-- March ( vol. 6 , no. 3 ). - P. 465-472 . - DOI : 10.1093 / hmg / 6.3.465 . - PMID 9147651 .
- ↑ Wang YK, Spörle R., Paperna T., Schughart K., Francke U. Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome (Eng.) // Genomics : journal. - Academic Press , 1999 .-- April ( vol. 57 , no. 2 ). - P. 235-248 . - DOI : 10.1006 / geno.1999.5773 . - PMID 10198163 .
- ↑ 1 2 Entrez Gene: FZD9 frizzled homolog 9 (Drosophila) .
Literature
- Datta DV Viral hepatitis (Chandigarh study) (neopr.) // The Journal of the Association of Physicians of India. - 1977. - May ( t. 25 , No. 5 ). - S. 325-330 . - PMID 914765 .
- Finch PW, He X., Kelley MJ, Uren A., Schaudies RP, Popescu NC, Rudikoff S., Aaronson SA, Varmus HE, Rubin JS Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action ) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 1997 .-- June ( vol. 94 , no. 13 ). - P. 6770-6775 . - DOI : 10.1073 / pnas.94.13.6770 . - PMID 9192640 .
- Tanaka S., Akiyoshi T., Mori M., Wands JR, Sugimachi K. A novel frizzled gene identified in human esophageal carcinoma mediates APC / beta-catenin signals (Eng.) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 1998 .-- August ( vol. 95 , no. 17 ). - P. 10164-10169 . - DOI : 10.1073 / pnas.95.17.10164 . - PMID 9707618 .
- Karasawa T., Yokokura H., Kitajewski J., Lombroso PJ Frizzled-9 is activated by Wnt-2 and functions in Wnt / beta -catenin signaling (Eng.) // The Journal of Biological Chemistry : journal. - 2002 .-- October ( vol. 277 , no. 40 ). - P. 37479-37486 . - DOI : 10.1074 / jbc.M205658200 . - PMID 12138115 .
- Omoto S., Hayashi T., Kitahara K., Takeuchi T., Ueoka Y. Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R ) // Ophthalmic Genetics: journal. - 2004 .-- June ( vol. 25 , no. 2 ). - P. 81-90 . - DOI : 10.1080 / 13816810490514270 . - PMID 15370539 .
- Winn RA, Marek L., Han SY, Rodriguez K., Rodriguez N., Hammond M., Van Scoyk M., Acosta H., Mirus J., Barry N., Bren-Mattison Y., Van Raay TJ, Nemenoff RA, Heasley LE Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation (Eng.) // The Journal of Biological Chemistry : journal. - 2005 .-- May ( vol. 280 , no. 20 ). - P. 19625-19634 . - DOI : 10.1074 / jbc.M409392200 . - PMID 15705594 .
- Rual JF, Venkatesan K., Hao T., Hirozane-Kishikawa T., Dricot A., Li N., Berriz GF, Gibbons FD, Dreze M., Ayivi-Guedehoussou N., Klitgord N., Simon C., Boxem M., Milstein S., Rosenberg J., Goldberg DS, Zhang LV, Wong SL, Franklin G., Li S., Albala JS, Lim J., Fraughton C., Llamosas E., Cevik S., Bex C. , Lamesch P., Sikorski RS, Vandenhaute J., Zoghbi HY, Smolyar A., Bosak S., Sequerra R., Doucette-Stamm L., Cusick ME, Hill DE, Roth FP, Vidal M. Towards a proteome-scale map of the human protein-protein interaction network (eng.) // Nature: journal. - 2005 .-- October ( vol. 437 , no. 7062 ). - P. 1173-1178 . - DOI : 10.1038 / nature04209 . - PMID 16189514 .
- Winn RA, Van Scoyk M., Hammond M., Rodriguez K., Crossno JT, Heasley LE, Nemenoff RA Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma (English) // The Journal of Biological Chemistry : journal. - 2006 .-- September ( vol. 281 , no. 37 ). - P. 26943-26950 . - DOI : 10.1074 / jbc.M604145200 . - PMID 16835228 .