NCR1 ( Eng. Natural cytotoxicity triggering receptor 1 , CD335) - membrane protein , receptor . Human gene product NCR1 ( LY94 ). [1] [2] Expressed on resting and activated natural killers .
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| , CD335, LY94, NK-p46, NKP46, natural cytotoxicity triggering receptor 1 | |||||||||||||
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Content
Functions
NCR1 is a cell toxicity activating receptor that can increase the potency of activated natural killer ( NK ) cells that cause tumor cell lysis .
Structure
The protein consists of 283 amino acids and includes the extracellular domain, the transmembrane region and the cytosolic domain. The extracellular domain contains 2 disulfide bonds and 1 N-glycosylated asparagine .
Interactions
Communicates with CD247 and FCER1G .
Notes
- ↑ Pessino A., Sivori S., Bottino C., Malaspina A., Morelli L., Moretta L., Biassoni R., Moretta A. Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity (English) // Journal of Experimental Medicine : journal. - Rockefeller University Press 1998 .-- September ( vol. 188 , no. 5 ). - P. 953-960 . - DOI : 10.1084 / jem.188.5.953 . - PMID 9730896 .
- ↑ Entrez Gene: NCR1 natural cytotoxicity triggering receptor 1 .
Literature
- Biassoni R; Cantoni c; Marras D; Giron-Michel, J .; Falco, Michela; Moretta, L .; Dimasi, N. Human natural killer cell receptors: insights into their molecular function and structure (Eng.) // J. Cell. Mol. Med. : journal. - 2004. - Vol. 7 , no. 4 . - P. 376-387 . - DOI : 10.1111 / j.1582-4934.2003.tb00240.x . - PMID 14754506 .
- Sivori S; Vitale M; Morelli L; Sanseverino, L; Augugliaro, R; Bottino, C; Moretta, L; Moretta, A. p46, a Novel Natural Killer Cell – specific Surface Molecule That Mediates Cell Activation (Eng.) // Journal of Experimental Medicine : journal. - Rockefeller University Press 1997. - Vol. 186 , no. 7 . - P. 1129-1136 . - DOI : 10.1084 / jem.186.7.1129 . - PMID 9314561 .
- Vitale M; Bottino C; Sivori S; Sanseverino, L; Castriconi, R; Marcenaro, E; Augugliaro, R; Moretta, L; Moretta, A. NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non – Major Histocompatibility Complex – restricted Tumor Cell Lysis (Eng.) // Journal of Experimental Medicine : journal. - Rockefeller University Press 1998. - Vol. 187 , no. 12 . - P. 2065-2072 . - DOI : 10.1084 / jem.187.12.12.2065 . - PMID 9625766 .
- Cantoni c; Bottino C; Vitale M; Pessino, A; Augugliaro, R; Malaspina, A; Parolini, S; Moretta, L; Moretta, A. NKp44, A Triggering Receptor Involved in Tumor Cell Lysis by Activated Human Natural Killer Cells, Is a Novel Member of the Immunoglobulin Superfamily (Eng.) // Journal of Experimental Medicine : journal. - Rockefeller University Press , 1999. - Vol. 189 , no. 5 . - P. 787-796 . - DOI : 10.1084 / jem.189.5.787 . - PMID 10049942 .
- Vankayalapati R; Wizel B; Weis SE; Safi, H; Lakey, DL; Mandelboim, O; Samten, B; Porgador, A; Barnes, PF The NKp46 receptor contributes to NK cell lysis of mononuclear phagocytes infected with an intracellular bacterium (Eng.) // J. Immunol. : journal. - 2002. - Vol. 168 , no. 7 . - P. 3451-3457 . - DOI : 10.4049 / jimmunol.168.7.3451 . - PMID 11907104 .
- Strausberg RL; Feingold EA; Grouse LH; Derge, JG; Klausner, RD; Collins, FS; Wagner, L; Shenmen, CM; Schuler, GD Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences // Proceedings of the National Academy of Sciences of the United States of America : journal. - 2003. - Vol. 99 , no. 26 . - P. 16899-16903 . - DOI : 10.1073 / pnas.242603899 . - PMID 12477932 .
- Augugliaro R; Parolini S; Castriconi R; Marcenaro, Emanuela; Cantoni, Claudia; Nanni, Marina; Moretta, Lorenzo; Moretta, Alessandro; Bottino, Cristina. Selective cross-talk among natural cytotoxicity receptors in human natural killer cells (Eng.) // Eur. J. Immunol. : journal. - 2003. - Vol. 33 , no. 5 . - P. 1235-1241 . - DOI : 10.1002 / eji.200323896 . - PMID 12731048 .
- Ponassi M; Cantoni c; Biassoni R; Conte, Romana; Spallarossa, Andrea; Pesce, Alessandra; Moretta, Alessandro; Moretta, Lorenzo; Bolognesi, Martino. Structure of the human NK cell triggering receptor NKp46 ectodomain (Eng.) // Biochem. Biophys. Res. Commun. : journal. - 2003. - Vol. 309 , no. 2 . - P. 317-323 . - DOI : 10.1016 / j.bbrc.2003.08.007 . - PMID 12951052 .
- Foster CE, Colonna M., Sun PD Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors (Eng.) // J. Biol. Chem. : journal. - 2003. - Vol. 278 , no. 46 . - P. 46081-46086 . - DOI : 10.1074 / jbc.M308491200 . - PMID 12960161 .
- Arnon TI; Achdout h; Lieberman N; Gazit, R; Gonen-Gross, T; Katz, G; Bar-Ilan, A; Bloushtain, N; Lev, M. The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46 (Eng.) // Blood : journal. - American Society of Hematology 2004. - Vol. 103 , no. 2 . - P. 664–672 . - DOI : 10.1182 / blood-2003-05-1716 . - PMID 14504081 .
- Marcenaro E; Augugliaro R; Falco M; Castriconi, Roberta; Parolini, Silvia; Sivori, Simona; Romeo, Elisa; Millo, Romano; Moretta, Lorenzo. CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity (Eng.) // Eur. J. Immunol. : journal. - 2004. - Vol. 33 , no. 12 . - P. 3367-3376 . - DOI : 10.1002 / eji.200324425 . - PMID 14635045 .
- Carbone E; Neri P; Mesuraca M; Fulciniti, MT; Otsuki, T; Pende, D; Groh, V; Spies, T; Pollio, G. HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells (Eng.) // Blood : journal. - American Society of Hematology 2005. - Vol. 105 , no. 1 . - P. 251—258 . - DOI : 10.1182 / blood-2004-04-1422 . - PMID 15328155 .
- Gerhard DS; Wagner L; Feingold EA; Shenmen, CM; Grouse, LH; Schuler, G; Klein, SL; Old, S; Rasooly, R. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) (Eng.) // Genome Res. : journal. - 2004. - Vol. 14 , no. 10B . - P. 2121-2127 . - DOI : 10.1101 / gr.2596504 . - PMID 15489334 .
- Mavoungou E., Bouyou-Akotet MK, Kremsner PG Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30) (English) // Clin. Exp. Immunol. : journal. - 2005. - Vol. 139 , no. 2 . - P. 287-296 . - DOI : 10.1111 / j.1365-2249.2004.02686.x . - PMID 15654827 .
- Nowbakht P; Ionescu MC; Rohner A; Kalberer, CP; Rossy, E; Mori, L; Cosman, D; De Libero, G; Wodnar-Filipowicz, A. Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias (eng.) // Blood : journal. - American Society of Hematology 2005. - Vol. 105 , no. 9 . - P. 3615-3622 . - DOI : 10.1182 / blood-2004-07-2585 . - PMID 15657183 .
- Poggi A; Massaro AM; Negrini S; Contini, P; Zocchi, MR Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors (English) // J. Immunol. : journal. - 2005. - Vol. 174 , no. 5 . - P. 2653-2660 . - DOI : 10.4049 / jimmunol . 17.5.5.2653 . - PMID 15728472 .
- Zilka A; Landau G; Hershkovitz O; Bloushtain, Noga; Bar-Ilan, Ahuva; Benchetrit, Fabrice; Fima, Eyal; Van Kuppevelt, Toin H .; Gallagher, John T. Characterization of the heparin / heparan sulfate binding site of the natural cytotoxicity receptor NKp46 (Eng.) // Biochemistry: journal. - 2006. - Vol. 44 , no. 44 . - P. 14477-14485 . - DOI : 10.1021 / bi051241s . - PMID 16262248 .
- Hermann E; Alonso-Vega C; Berthe A; Truyens, Carine; Flores, Amilcar; Cordova, Marisol; Moretta, Lorenzo; Torrico, Faustino; Braud, Veronique. Human congenital infection with Trypanosoma cruzi induces phenotypic and functional modifications of cord blood NK cells (Eng.) // Pediatr. Res. : journal. - 2006. - Vol. 60 , no. 1 . - P. 38-43 . - DOI : 10.1203 / 01.pdr.0000220335.05588.ea . - PMID 16690951 .