Denis Borisovich Tikhonov (born August 27, 1968 ) - Russian biophysicist , deputy director for science at the Institute of Evolutionary Physiology and Biochemistry named after IM Sechenov, Russian Academy of Sciences , corresponding member of the Russian Academy of Sciences (2016).
| Denis Borisovich Tikhonov | |
|---|---|
| Date of Birth | August 27, 1968 (50 years) |
| A country |  USSR →  Russia |
| Scientific field | molecular physiology |
| Place of work | Institute of Evolutionary Physiology and Biochemistry named after IM Sechenov, Russian Academy of Sciences , St. Petersburg State University |
| Academic degree | Doctor of Biological Sciences (2004) |
| Academic title | Corresponding Member of the Russian Academy of Sciences (2016) |
Doctor of Biological Sciences (2004) [1] , a specialist in the field of molecular physiology and pharmacology of ion channels, author of 74 scientific papers.
In 2016 - elected a corresponding member of the Russian Academy of Sciences .
Scientific Activities
Main scientific results:
- the mechanisms of blockade of the ion channels of the glutamate receptors by organic cations of different structures were investigated, approaches were developed that allowed in vitro experiments to obtain characteristics of the action of blockers adequate to physiological and pathological conditions;
- investigated the structural determinants of blockade of ion channels of glutamate receptor subtypes and created models of these channels, with the help of which the directed design of new selective blocking compounds is carried out;
- The mechanisms of action and binding sites of pharmacologically significant compounds, such as tetrodotoxin and its analogs, mu-conotoxins, local anesthetics, batratotoxin, veratridine and their analogues, benzodiazipines, dihydropyridines and phenylalkylamines, have been investigated in the potential of controlled sodium, potassium and calcium channels;
- The specific potentiating and inhibiting effects of hydrophobic monoamines on proton-activated ion channels in the central nervous system have been discovered. Histamine has been shown to be a specific potentiator of one of the subtypes of these channels.
Conducts teaching, lecturing at St. Petersburg State University and in the IESE named after. IM Sechenov RAN.
Notes
- ↑ Thesis on the topic “Study of the structure and mechanisms of blockade of ion channels of nicotinic cholinergic receptors and glutamate receptors”, abstract . dissercat.com. The appeal date is May 5, 2018.
- ↑ Tikhonov D. B. - General Information . ras.ru. The appeal date is May 5, 2018.
Links
- Tikhonov, Denis Borisovich on the official website of the Russian Academy of Sciences