Dymshits, Grigory Moiseevich

Specialist in the field of molecular and cellular biology, studying the structure and functioning of the genome, chemical modification of nucleic acids. He developed a method of double modification of DNA with carbodiimide and phosphoric tungsten acid. He developed a method for obtaining and luminescent-microscopic visualization of directed single-stranded breaks in the DNA of polytene chromosomes, based on the principle of complementary addressed modifications. Created a system of chemical non-radioactive labeling of both RNA and DNA probes for molecular hybridization, based on the introduction of polynucleotides by alkylation or transamination of amino groups with the subsequent addition of reporter compounds to them. Developed test systems for non-radioactive diagnosis of cattle leukemia, tropical malaria, and mycoplasma cell culture contamination. He participated in the development of a colorimetric test system for detecting point mutations. He developed a system for colorimetric detection of single nucleotide polymorphisms in several regions of the human Y chromosome. He investigated the molecular genetic mechanisms of the development of arterial hypertension and stress reactivity in animal models with stress-induced arterial hypertension. He studied the expression of key genes of the hypothalamic-pituitary-adrenocortical, renin-angiotensin and sympatho-adrenal systems in rats of the ISIAH hypertensive line and WAG normotensive line. He studied the nuclear and mitochondrial determinants of the trait cytoplasmic male sterility in sugar beet Beta vulgaris . Identified structural variations of mtDNA in regions of a number of genes associated with this trait.

• 1943 - was born in Novosibirsk in a family of employees. Father - Dymshits Moisey Sanovich (1914-1989), chief designer of the Aviation Plant named after Chkalov; mother - Dymshits Faina Ksilyevna (1920-1991), a doctor. ^[one]
• 1961-1966 - student of the biological department of the Faculty of Natural Sciences of Novosibirsk State University.
• 1966 - Lecturer in Biology at the SSC of NSU (PhMS)
• 1966-1968 - intern researcher at the Institute of Cytology and Genetics, Siberian Branch of the USSR Academy of Sciences.
• 1968-1986 - Junior Researcher, Laboratory of Nucleic Acids (since 1973, the Laboratory of Molecular Genetics), Institute of Cytology and Genetics, USSR Academy of Sciences
• 1971 - candidate of biological sciences. The dissertation on “Investigation of the state of DNA of the regenerating rat liver during replication” is defended under the guidance of prof. R. I. Salganika.
• 1971 - Assistant, Department of General Biology, FEN NSU
• 1976 - Associate Professor at the Department of "Molecular Biology"
• 1986-1992 - Senior Researcher, Laboratory of Molecular Genetics, Institute of Cytology and Genetics, Siberian Branch of the USSR Academy of Sciences.
• 1988 - Associate Professor, Department of Natural Sciences, SSC, NSU
• 1990 - Senior Researcher with a degree in Molecular Biology
• 1992 - Doctor of Biological Sciences. The dissertation on the topic "Chemically modified nucleic acids as a tool for studying the structurally functional organization of the eukaryotic genome."
• 1992-1994 - head of the genome structure sector of the Institute of Cytology and Genetics SB RAS
• 1993 - Professor, Department of Molecular Biology, FEN NSU
• 1994 - Professor, Department of Molecular Biology
• 1994 - head of the genome structure laboratory of the Institute of Cytology and Genetics SB RAS
• 2001 - Head of the Department of Natural Sciences, SSC of NSU

Teaching activities

• 1966 - conducts lecture and seminar classes in general biology in the final class at the School of Physics and Mathematics (SSC of NSU), gives a special course "Molecular Biology".
• 1971 - General Biology course for 1st year biology students, Cytology course for 3rd year biology students of FEN NSU.
• 1976 - directs the institute practice of molecular biologists 4 and 5 courses FEN NSU.
• 1993—2000 - course "Cell Biology" for environmental chemists 1 course
• 1986 - the course "Molecular Biology" for biology students of the 2nd year of FEN NSU.
• 1991 - special course "Basic molecular genetic processes" for molecular biologists and chemists, biochemists, 5 year of NSU.
• 2008 - the course "Molecular Biology" for biologists and physicians 2 courses, biophysicists and biochemists 4 courses NSU
• 2012 - special course "Mechanisms of replication, transcription and translation" for molecular biologists and biochemists 5th year FEN NSU

Community Activities

• Member of the Academic Council of the Institute of Cytology and Genetics SB RAS.
• Member of the Council for the defense of doctoral dissertations at the Institute of Chemical Biology and Fundamental Medicine SB RAS.
• Member of the Academic Council of SSTC NSU.
• Member of the Methodological Commission for Biology FEN NSU.

Awards and Titles

• Veteran of labour.
• Honorary badge and title "Honored Veteran of the Siberian Branch of the RAS"
• The badge of honor "Silver Sigma" (2007).

Family

Married. I have a daughter.

G. M. Dymshits is the author of 250 works, including 2 monographs. Co-author and co-editor of 5 school books on general biology ^[1]

• Salganik RI, Dashkevich VS, Dymshits GM Studies of replicating DNA of regenerating rat liver using chemical modifications with water-soluble carbodiimide // Biochem. Biophys. Acta, 1967. V. 149. P. 603-606.
• Dymshits G. M., Dashkevich V. S., Salganik R. I. Investigation of some properties of “hybrid” RNA as a part of rat liver DNA // Mol. Biol., 1968. T. 2.P. 508-512.
• Dymshits G. M., Fet V. Ya. Protein factor from the regenerating liver of rats, destabilizing the secondary structure of DNA // Mol. Biol., 1977.Vol. 11. S. 531-536.
• Dymshits G.M., Rumyantseva G.V., Frumgarts L.A. et al. Induction of directional breaks in DNA of polytene chromosomes of Chironomus thummi in situ under the action of alkylating derivatives of oligoadenylates // Mol. Biol., 1981. T. 15. S. 86-95.
• Frumgarts L.A., Kalachikov S.M., Dymshits G.M. Introduction of a fluorescent label into polynucleotides and investigation of the effect of their modification on the ability to complementary interactions // Mol. Biol., 1985.Vol. 19.P. 1394-1399.
• Kalachikov S.M., Adarichev V.A., Dymshits G.M. Immobilization of DNA on microporous membranes using UV irradiation // Bioorganic chemistry, 1992.V. 18. S. 52-62.
• Kalachikov S. M., Kel A. E., Dymshits G. M. et al. Cloning of universal probes to detect mycoplasma infection of cell cultures // Mol. Biol., 1994.Vol. 28.S. 444-452.
• Wlassoff WA, Dymshits GM, Lavrik OI A model for DNA polymerase translocation: worm-like movement of DNA within the binding cleft // FEBS Letters, 1996. V. 390. P. 6-9.
• Zarytova VF, Pyshnyi DV, Krivenko AA, Dymshitz GM et al. The accurate detection of one point mutations by ligation of short oligonucleotides // Nucleosides & Nucleotides, 1998. V. 17. P. 2143-2147.
• Hvorostov I. B., Dikalova A. E., Veprev S. G., Maletsky S. I., Dymshits G. M. Comparative analysis of molecular methods for typing the cytoplasm of sugar beet (Beta vulgaris L.) // Genetics, 1998. T 34.P. 644-649.
• Adarichev VA, Kalachikov SM, Kiseliova AV, Dymshits GM Molecular hybridization probes prepared with 4-aminooxybutylamine // Bioconjugate Chemistry, 1998. V. 9. P. 671-675.
• Skobeltsyna L. M., Pyshniy D. V., Shishkina I. G., Tabatadze D. R., Dymshits G. M. et al. Development of a colorimetric test system for detecting point mutations by ligation of the tandem of short oligonucleotides on a solid-phase carrier / / Mol. Biol., 2000.V. 34.P. 378-385.
• Lapteva N., Ide K., Nieda M., Ando Y., Hatta-Ohashi Y., Minami M., Dymshits G. et al. Activation and suppresion of renin-angiotensin system in human dendritic cells // Biochem. and Biophys. Res. Communic., 2002. V. 296. P. 194-200.
• Hvorostov I. B., Ivanov M. K., Dymshits G. M. Mitochondrial genome of higher plants: regulation of gene expression // Mol. Biol., 2002.Vol. 36.S. 408-417.
• Kabilov M., Pyshnyi D., Dymshits G. et al. A new approach torevealing point mutations in DNA analyzed by colorimetric detection // Nucleosides, Nucleotides & Nucleic Acids, 2004. V. 23. Nos. 6, 7. R. 1023-1030.
• Bragin A. G., Glushkov S. A., Ivanov M. K., Krasnov A. A., Dymshits G. M. Determination of DNA polymerase and nuclease activities of DNA-dependent polymerases using real-time fluorescence detection // Biochemistry, 2008, v. 73, v. 9, p. 1252-1264
• Dymshits G. M., Bragin A. G., Ivanov M. K. Molecular genetic aspects of cytoplasmic male sterility. Encyclopedia of the genus Beta. Biology, genetics and selection of beets. //Collection of scientific papers. Institute of Cytology and Genetics SB RAS, Russia; Sugar Beet Institute, Ukraine. Novosibirsk: Sova Publishing House, 2010, 686 pp., P. 228-247.
• Fedoseeva LA, Antonov EV, Klimov LO, Dymshits GM, Markel AL Function of the rennin-angiotensin-aldosterone system in the ISIAH rats with stress-sensitive arterial hypertension In: Renin-Angiotensin System, Editors: A. Himura, T. Sato / / Nova Science Publishers, 2013, pp. 1-43.
• Dymshits G.M., Zakharov I.K. Molecular genetics at the Institute of Cytology and Genetics of the Siberian Branch of the Academy of Sciences of the USSR (from 1957 to the 1970s) // Vavilovsky Journal of Genetics and Selection, 2013, v.17, No. 2, p.214 -225.
• Dymshits GM, Sablina OV Split Genes and Splicing // Russian Journal of Genetics: Applied Research, 2014, Vol. 4, No. 4, pp. 292-300.

Tutorials

• Sablina O. V., Dymshits G. M. Modern biology. Textbook // Novosibirsk State University, Novosibirsk, 2011, 208 pp.
• Dymshits G. M., Sablina O. V. Molecular foundations of modern biology. Textbook // Novosibirsk State University, Novosibirsk, 2012, 251 pp.
• Dymshits G. M., Sablina O. V., Vysotskaya L. V., Borodin P. M. “Biology. General Biology »Workshop for students in grades 10-11 of general educational organizations. Profile level. // Moscow, "Education", 2014, 143 pp.
• Belyaev D. K., Dymshits G. M., Kuznetsova L. N., Sablina O. V., Shumny V. K. “Biology Grade 10” Textbook for educational organizations. A basic level of. Edited by D. K. Belyaev and G. M. Dymshits // Moscow, Education, 2014, 224 pp.
• Belyaev D. K., Borodin P. M., Dymshits G. M., Kuznetsova L. N., Sablina O. V., Sergeev M. G. “Biology 11 class” Textbook for educational institutions. A basic level of. Edited by D. K. Belyaev and G. M. Dymshits // Moscow, Education, 2014, 224 pp.
• Borodin P.M., Vysotskaya L.V., Dymshits G.M., Mednikov B.M., Ruvinsky A.O., Sablina O.V., Salganik R.I., Sergeev M.G., Shumny V K. "Biology 10-11 classes" Textbook for educational organizations. Advanced level. In two parts. Edited by Academician V.K. Shumny and Professor G. M. Dymshits // Moscow, Education, 2014, part 1 - 303 pages, part 2 - 287 pages.
• Vysotskaya L. V., Dymshits G. M., Ruvinsky A. O., Sablina O. V., Kuznetsova L. N. “Biology Grade 10” Textbook for educational institutions. Advanced level. Edited by V.K. Shumny and G.M. Dymshits // Moscow "Enlightenment", 2017, 376 pp.
• Borodin P. M., Dymshits G. M., Sablina O. V., Sergeev M. G., Shumny V. K., Khlestkina E. K., Kuznetsova L. N. “Biology 11 class” Textbook for educational institutions . Advanced level. Edited by V.K. Shumny and G.M. Dymshits // Moscow, "Education", 2017, 384 pp.
• G. M. Dymshits, O. V. Sablina “25 Illustrated Lectures on Molecular Biology” Textbook // Novosibirsk, 2017, Novosib. Gos. University, 178 pp.