Cyclopirox is a synthetic antifungal drug for local dermatological treatment of superficial mycoses. It is sold under many trademarks around the world [1] .
| Cyclopirox | |
|---|---|
 | |
| Chemical compound | |
| IUPAC | 6-cyclohexyl-1-hydroxy-4-methylpyridin-2 (1 H ) -one |
| Gross formula | C 12 H 17 NO 2 |
| Molar mass | 207.269 g / mol |
| Cas | |
| PubChem | |
| Drugbank | |
| Classification | |
| ATX | |
| Pharmacokinetics | |
| Bioavailable | <5% with prolonged use |
| Plasma Protein Binding | 94 to 97% |
| The half-life. | 1.7 hours |
| Route of administration | |
| applied as nail polish or shampoo | |
Indications for use
Ciclopirox is indicated for the treatment of lichen and seborrheic dermatitis . It is necessary to avoid contact with the eyes and the reproductive organs, during pregnancy, you need to consult a doctor, since it is not known whether cyclopirox passes into breast milk. May cause a burning sensation on first use (Paddock Laboratories, Inc., Oct. 2009).
Mechanism of Action
Unlike azoles and other antifungal drugs, the mechanism of action of cyclopirox is poorly understood [2] . It is currently being investigated as an alternative ketoconazole treatment for seborrheic dermatitis because it inhibits the growth of Malassezia furfur yeast. Initial results show efficacy comparable to ketoconazole, with a subjectively more noticeable symptom relief due to anti-inflammatory action [3] .
Effectiveness in the treatment of nail infections
In addition to other drugs, cyclopirox is used in varnishes for topical treatment of onychomycosis (fungal infections of the nails). A meta-analysis of six infection tests available in 2009 concluded that topical cyclopiroxolamine has low cure rates and that amorolfine may be significantly more effective, but more research is needed.
The combination of data from 2 studies of cyclopiroxamine and placebo showed that in the treatment with cyclosporoxamines, the level of 61% and 64% in patients with syncopyroxolamine was 61% and 64%. Long treatment times (48 weeks) make cyclopiroxolamine a poor choice for nail infections. When using amorolfine varnish, 6% of treatment failure cases were detected after 1 month of treatment, but these data were collected on a very small sample of people, and these high success rates may be unreliable. [four]
Notes
- β Drugs.com International brand names for ciclopirox Page accessed January 201, 2016
- β Niewerth M., Kunze D., Seibold M., Schaller M., Korting HC, Hube B. Ciclopirox Olamine Treatment Affects the Expression Pattern of Candida albicans Genes Encoding Virulence Factors, Iron Metabolism Proteins, and Drug Resistance Factors (English) // Antimicrobial Agents and Chemotherapy : journal. - 2003 .-- June ( vol. 47 , no. 6 ). - P. 1805-1817 . - DOI : 10.1128 / AAC.47.6.1805-1817.2003 . - PMID 12760852 .
- β Leem SH, Park JE, Kim IS, Chae JY, Sugino A., Sunwoo Y. The possible mechanism of action of ciclopirox olamine in the yeast Saccharomyces cerevisiae (Eng.) // Mol. Cells : journal. - 2003. - Vol. 15 , no. 1 . - P. 55β61 . - PMID 12661761 .
- β Ratnavel RC, Squire RA, Boorman GC Clinical efficacies of shampoos containing ciclopirox olamine (1.5%) and ketoconazole (2.0%) in the treatment of seborrhoeic dermatitis (English) // J Dermatolog Treat : journal. - 2007. - Vol. 18 , no. 2 . - P. 88-96 . - DOI : 10.1080 / 16537150601092944 . - PMID 17520465 .