Ceftaroline (Latin Ceftaroline fosamil) is an antibiotic of the fifth generation cephalosporin class.
| Ceftaroline | |
|---|---|
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| Chemical compound | |
| IUPAC | (6R, 7R) -7 - [(2Z) -2-Ethoxyimino-2- [5- (phosphonamino) -1,2,4-thiadiazol-3-yl] acetyl] amino] -3- [4- (1 methylpyridin-1-yum-4-yl) -1,3-triazol-2-yl] sulfanyl] -8-oxo-5-thia-1- azabicyclo [4.2.0] oct-2-en-2-carboxylate |
| Gross formula | C 22 H 21 N 8 O 8 PS 4 |
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| Drugbank | |
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Content
Mechanism of Action
Ceftaroline fosamil has activity against gram-positive and gram-negative microorganisms. The bactericidal effect of ceftaroline is due to inhibition of the biosynthesis of the bacterial cell wall by binding to penicillin-binding proteins (PSB).
Indications
- Complicated infections of the skin and soft tissues caused by susceptible strains of the following gram-positive and gram-negative microorganisms: Staphylococcus aureus (including methicillin-resistant), Streptococcus pyogenes , Streptococcus agalactiae, Streptococcus anginosus, Streptococcus dysgalactiella coli , and Streptococcus dysgalactiella coli ,
- Community-acquired pneumonia caused by susceptible strains of the following gram-positive and gram-negative microorganisms: Streptococcus pneumoniae (including cases accompanied by bacteremia), Staphylococcus aureus (including methicillin-resistant [1] ), Haemophilus influenzae , Haemophilus parainfluenzaeiheielei coli .
Contraindications
- Hypersensitivity to ceftaroline fosamil or L-arginine;
- hypersensitivity to cephalosporins;
- severe immediate hypersensitivity reactions (eg, anaphylactic reaction ) to any other antibacterial agent with a beta-lactam structure (eg penicillins or carbapenems );
- children under 18 years old.
Drugs
- Zinforo (manufactured by Pfizer )
- Teflaro (in the USA)
Notes
- ↑ Christopher Duplessis, Nancy F. Crum-Cianflone. Ceftaroline: A New Cephalosporin with Activity against Methicillin-Resistant Staphylococcus aureus (MRSA) // Clinical medicine reviews in therapeutics. - 2011-02-10. - T. 3 . - ISSN 1179-2558 . - DOI : 10.4137 / CMRT.S1637 .