Magazanik, Lev Girshevich

Born April 19, 1931 in Odessa in the family of a military doctor.

In 1933, the family moved to Leningrad, where his father was given a new job.

He graduated from high school with a silver medal and without entrance exams was enrolled in the 1st Medical Institute named after academician I.P. Pavlov . By distribution, after graduating from a medical institute in 1955-57, he worked as the chief doctor of a tuberculosis hospital in the village of Kurkiyoki, Karelian Autonomous Soviet Socialist Republic.

In 1957 he transferred to work at the Sechenov Institute of Evolutionary Physiology and Biochemistry , which since January 1956 became the new scientific center of Leningrad. In those days it was headed by the outstanding physiologist L. A. Orbeli , the classics of Russian physiology A. G. Ginetsinsky , E. M. Kreps worked, and began working in the laboratory of pharmacology under the guidance of Professor M. Ya. Michelson, in which comparative pharmacological studies to elucidate the molecular structure and function of cholinergic receptors and cholinesterases and their changes during evolution.

In 1959 - defended his thesis, theme: "The mechanism and experimental therapy of bronchospasm caused by some cholinopositive substances."

In 1969 - became the head of the laboratory of biophysics of synaptic processes, which he himself founded.

In 1970 - defended his doctoral dissertation, topic: "Mechanisms of activation of the postsynaptic muscle membrane."

In 1996, he was elected professor of the Department of Physiology of the Medical Faculty of St. Petersburg State University.

In 1997 - was elected a corresponding member of the RAS.

In 2016, he was elected an academician of the RAS.

At present, he is the chief researcher at the Institute of Evolutionary Physiology and Biochemistry named after I.M.Sechenova.

Leading specialist in the field of domestic and foreign neurophysiology.

He studied the molecular mechanisms of synaptic transmission, in particular the postsynaptic action of mediators, the functioning of ion channels and others, the selective action of various neurotoxins on certain types of receptors.

A pioneer in the creation of new tools for studying the molecular organization of channels of biological membranes, as well as the discovery of the selective effect of a number of new neurotoxins on certain types of synaptic receptors. One of the first synaptologists, he began to elucidate the subtle molecular mechanisms of presynaptic modulation of exocytosis of mediators in order to find ways of pharmacological control over this poorly studied process.

He conducted joint research in the scientific laboratories of the universities of Paris (1990-1991), Geneva (1993), Nottingham (1994-1995), Munich (1998), the results of which received brilliant reviews and were a huge contribution to the world treasury of neurobiology, serve as a fundamental contribution to the development new drugs for the management of synaptic processes between neurons in healthy and sick.

Author of over 250 articles. Among Russian physiologists, he is one of the most frequently cited in world literature.

Participation in scientific organizations:

• co-chairman of the organizing committee of the All-Russian conference "Man and his health"
• Deputy Chairman of the Dissertation Council, I. Sechenov Institute of Evolutionary Physiology and Biochemistry RAS ^[1]
• honorary member of the British Physiological Society
• Member of the US Neuroscience Society
• member of the J. Purkinje Society (Czech Republic)
• Board member of the I.P. Pavlov Physiological Society
• Chairman of the Problem Commission for Nerve Cell Physiology, Scientific Council of the Russian Academy of Sciences for Physiological Sciences
• Member of the Bureau of the Scientific Council for Biological Membranes, Russian Academy of Sciences

In 1979, he acted as editor of the translation of the book by S. Kuffler and J. Nichols “From Neuron to the Brain”.

At St. Petersburg State University at the Faculty of Medicine, he gives a lecture course in the physiology of the nervous and sensory systems for second-year students of the Faculty of Medicine.

Under his leadership, 3 doctoral and 13 master's theses were defended.

The projects of his scientific research during 1997-2007 are encouraged by "Grants of the President of the Russian Federation to support young scientists and leading scientific schools of the Russian Federation."

In January-February 2006, in Moscow, on the basis of the Faculty of Fundamental Medicine of Moscow State University, he participated in the school "Modern course of lectures in classical physiology", in which he gave a lecture "The structure and functions of central and neuromuscular synapses."

• USSR State Prize (with group members, for 1989) - for studying the mechanisms of blocking chemically controlled ion channels in peripheral synapses
• Order of Friendship (2002)
• L. A. Orbeli Prize (2016) - for the series of works “Research on the evolution of molecular mechanisms of synaptic transmission”
• title “ Soros Professor ” (1999-2003)
• Medal “In memory of the 300th anniversary of St. Petersburg” (2003)
• Emeritus Professor, Kazan Medical University (2001)

• Magazanik, Lev Girshevich on the official website of the RAS
• Magazanik Lev Girshevich (IS ARAN) (neopr.) . isaran.ru. Date of treatment December 9, 2016.
• Bulletin of the Union of Physiological Societies of the CIS Countries, Corresponding Member of the Russian Academy of Sciences L. G. Magazanik is 80 years old! (unspecified) (pdf). physiology-cis.org. Date of treatment December 9, 2016.