Not to be confused with C-reactive protein .
| protein C | |
|---|---|
 Blood coagulation: thrombin pathway and protein C pathway (according to John Griffin). | |
| Designations | |
| Characters | PROC |
| Entrez gene | 5624 |
| Hgnc | 9451 |
| Omim | 176860 |
| Refseq | NM_000312 |
| Uniprot | P04070 |
| Other data | |
| Cipher cf | 3.4.21.69 |
| Locus | 2nd hr. , 2q13 -q21 |
Protein C (activated coagulation factor XIV, English protein C , EC 3.4.21.69 ) is the main physiological anticoagulant . Protein C refers to vitamin K- dependent proteolytic enzymes (serine protease), which is activated by the action of thrombin . At the same time, it turns into activated protein C , which is able to bind to protein S and break down coagulation factors Va and VIIIa .
Activated protein C is the main enzyme of the cascade pathway of protein C, which provides physiological antithrombotic activity of the blood and also has pronounced anti-inflammatory and anti-apoptotic activities. Due to these features, recombinant activated protein C is currently one of the drugs used in sepsis for the prevention of DIC . [one]
See also
- Protein C Endothelial Receptor
- Thrombomodulin
- Proteinase K
Notes
- β Jenkins I. Evidence-based sepsis therapy: a hospitalist perspective (Eng.) // Journal of hospital medicine (Online): journal. - 2006. - Vol. 1 , no. 5 . - P. 285-295 . - DOI : 10.1002 / jhm.116 . - PMID 17219514 .
Links
- Limitation of blood coagulation by inactivation of factor Va
- Relative antithrombotic and antihemostatic effects of protein C activator versus low molecular weight heparin in primates , Gruber A, Marzec UM, Bush L, Di Cera E, Fernandez JA, Berny MA, Tucker EI, McCarty OJ, Griffin JH, Hanson SR., Blood (2007) - 310 articles by Griffin, et. al. are represented at this link
- The cytoprotective protein C pathway , Mosnier LO, Zlokovic BV, Griffin JH., Blood (2006)
- The Protein C Pathway - John H. Griffin, retired, TSRI , La Jolla, California
- Diagram of The Blood Coagulation Pathway and Protein C Pathway