Asprosin ( Asprosin ) is a protein whose hormone is produced by white adipose tissue in mammals (and possibly other tissues), which is then transported to the liver and stimulates it to release glucose into the bloodstream. Liver asprosin activates the rapid release of glucose by the c-AMP-dependent pathway. The release of glucose in the liver into the bloodstream is vital for brain function and survival during fasting. People with neonatal progeroid syndrome have an insufficient amount of the hormone Asprospina, while people with insulin resistance have it in abundance.
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Asprosin is generated from the FBN1 gene (amino acid residues 2732–2871), which also creates the fibrillin protein.
Content
Opening
Asprosyn was identified by the laboratory of Dr. Atul Chopra and his colleagues at Baylor College of Medicine, Houston, Texas. The study analyzed the DNA of two patients with neonatal progeroid syndrome (NPS). NPS patients suffer from two different pathologies - Marfan syndrome, due to fibrillin protein mutations, as well as a decrease in glucose production in the liver due to the lack of asprosin. The truncation of the FBN1 mutation in these patients leads to two effects at the protein level - the production of mutant / truncated fibrillin protein, and as a result of its dominant and negative effect, has a very low plasma level of asprosin.
Therapeutic potential
In animal studies, asprosyn has shown potential for the treatment of type 2 diabetes . When the targeted Asprosin antibodies were injected into mice and diabetics, their blood glucose levels and insulin levels improved.
Notes
Links
- Romere C, Duerrschmid C, Bournat J, Constable P, Jain M, Xia F, et al. (2016). "Asprosin, a Fasting-Induced Glucogenic Protein Hormone." Cell 165 (3): 566-79. doi : 10.1016 / j.cell.2016.02.063 . PMID 27087445 .
- "Discovery of asprosin, new hormone could have potential implications in treatment of diabetes . " Baylor College of Medicine . Apr 14, 2016. Retrieved 18 April 2016.
- Grens K (April 15, 2016). "Newly Discovered Hormone Explains Disease" . The Scientist . Retrieved 18 April 2016.
- Coghlan A (14 April 2016). “Newly discovered hormone could fight type 2 diabetes and obesity” . New Scientist. Retrieved 20 April 2016.