Medium-chain acyl-CoA dehydrogenase of fatty acids (also MCAD , abbreviated from English Medium-chain ac yl- C oA d ehydrogenase , EC 1.3.8.7 ) is one of the mitochondrial enzymes of the acyl-CoA dehydrogenase group, class oxidoreductases . The systematic name of the enzyme is electron-transporting flavoprotein-dependent 2,3-oxidoreductase [1] . This enzyme is involved in the process of β-oxidation of fatty acids. The gene encoding this enzyme, ACADM, is located on the 1st human chromosome .
| Medium Chain Human Acyl CoA Dehydrogenase Fatty Acids | |
|---|---|
 Medium-chain acyl-CoA dehydrogenase tetramer, Human | |
| Identifiers | |
| Cipher cf | 1.3.8.7 |
| Enzyme bases | |
| Intenz | Intenz view |
| BRENDA | BRENDA entry |
| Expasy | NiceZyme view |
| Metacyc | metabolic pathway |
| Kegg | KEGG entry |
| PRIAM | profile |
| PDB structures | RCSB PDB PDBe PDBj PDBsum |
| Search | |
| PMC | articles |
| PubMed | articles |
| NCBI | NCBI proteins |
It catalyzes the elimination (cleavage) reaction of protons from a substrate - acyl-CoA fatty acids with an average hydrocarbon chain length (from C8 to C14) to the electron-transporting flavoprotein ( FAD ), which serves as a prosthetic group :
Medium Hydrocarbon Chain Acyl-CoA Fatty Acid + FAD trans-2,3-dehydroxyacyl-CoA fatty acid with an average hydrocarbon chain length + FADH 2
See also
- β-oxidation
Notes
- ↑ Toogood HS , van Thiel A. , Basran J. , Sutcliffe MJ , Scrutton NS , Leys D. Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain Acyl-CoA dehydrogenase complex. (English) // The Journal of biological chemistry. - 2004. - Vol. 279, no. 31 . - P. 32904-32912. - DOI : 10.1074 / jbc.M404884200 . - PMID 15159392 .