Methamphepramone

Methamphepramone
Methamphepramone
Are common
Systematic ; name	2- (dimethylamino) -1-phenyl-1-propanone
Traditional names	Dimethylcathinone, Dimethylpropion, Dimepropion, N-Methylephedrone
Chem. formula	C 11 H 15 NO
Physical properties
Molar mass	177.243 g / mol
Density	1.0 ± 0.1 g / cm³
Classification
Reg. CAS number
PubChem
Reg. EINECS number
Smiles
Inchi
ChemSpider

Methampheramone ( INN ), also known as dimethylpropion, dimethylmethcathinone or N-methylephedrone - a chemical compound of the class of phenylethylamines and cathinones , a psychostimulant .

Content

Usage

Metamfepramone has been rated as an appetite suppressant and hypotension medication, but has never been widely marketed ^[1] .

It was distributed in Israel under the name rakefet as a recreational drug , but was banned in 2006 ^[2] .

Getting

Racemic methamphepramone is obtained through the reaction of 2-bromopropiophenone with dimethylamine ^[3] . (2S) - (-) - dimethylcathinone is obtained by oxidation of (1R, 2S) - (-) - N-methylephedrine with a solution of sulfuric acid- sodium dichromate at a temperature of −5 ° C ^[3] .

Metabolism

Metamfepramone rapidly decomposes in the body into methcathinone and N-methylpsevdoephedrine ^[4] .

Legal Status

N-methylephedrone and its derivatives are included in list I of the list of narcotic drugs, psychotropic substances and their precursors to be controlled in the Russian Federation ^[5] .

Notes

↑ Soholing WE Therapy of the orthostatic syndrome. Studies using dimepropion-HCl (German) // Fortschritte der Medizin. - 1982. - T. 100 , No. 7 . - S. 289-293 .
↑ Judy Siegel-Itzkovich. Recreational drug 'rakefet' banned (neopr.) . Jpost.com (February 22, 2006). Date of treatment June 13, 2016.
↑ ¹ ² Terry A. Dal Cason Synthesis and Identification of N, N-Dimethylcathinone Hydrochloride Archived September 28, 2015 on the Wayback Machine
↑ Thevis, M; Sigmund, G; Thomas, A; Gougoulidis, V; Rodchenkov, G; Schänzer, W. Doping control analysis of metamfepramone and two major metabolites using liquid chromatography-tandem mass spectrometry (English) // European Journal of Mass Spectrometry : journal. - 2009. - Vol. 15 , no. 4 . - P. 507-515 . - DOI : 10.1255 / ejms.1010 . - PMID 19661559 .
↑ Decree of the Government of the Russian Federation of June 30, 1998 No. 681 “On approval of the list of narcotic drugs, psychotropic substances and their precursors subject to control in the Russian Federation” (as amended)

[1] Soholing WE Therapy of the orthostatic syndrome. Studies using dimepropion-HCl (German) // Fortschritte der Medizin. - 1982. - T. 100 , No. 7 . - S. 289-293 .

[2] Judy Siegel-Itzkovich. Recreational drug 'rakefet' banned (neopr.) . Jpost.com (February 22, 2006). Date of treatment June 13, 2016.

[Terry-3] ¹ ² Terry A. Dal Cason Synthesis and Identification of N, N-Dimethylcathinone Hydrochloride Archived September 28, 2015 on the Wayback Machine

[4] Thevis, M; Sigmund, G; Thomas, A; Gougoulidis, V; Rodchenkov, G; Schänzer, W. Doping control analysis of metamfepramone and two major metabolites using liquid chromatography-tandem mass spectrometry (English) // European Journal of Mass Spectrometry : journal. - 2009. - Vol. 15 , no. 4 . - P. 507-515 . - DOI : 10.1255 / ejms.1010 . - PMID 19661559 .

[5] Decree of the Government of the Russian Federation of June 30, 1998 No. 681 “On approval of the list of narcotic drugs, psychotropic substances and their precursors subject to control in the Russian Federation” (as amended)