Sergei Arturovich Nedospasov (born 1952) is a Soviet and Russian biologist , a specialist in the field of molecular biology and genetics , immunology and biotechnology .
| Sergey Arturovich Nedospasov | |
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| Date of Birth | |
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| Academic degree | Doctor of Biological Sciences |
| Academic rank | academician of RAS |
| supervisor | G.P. Georgiev |
| Awards and prizes |  Prize named after I.I. Mechnikov |
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Doctor of Biological Sciences, Professor, Corresponding Member of the Russian Academy of Sciences (since 2003) with a degree in biotechnology, Academician of the Russian Academy of Sciences (from 10.28.2016) with a degree in Physicochemical Biology. Member of the European Academy . Head of the Laboratory of Molecular Mechanisms of Immunity, Institute of Molecular Biology V. A. Engelhardt RAS , Head of the Department of Molecular Immunology, Institute of Physical and Chemical Biology A. N. Belozersky and Head of the Department of Immunology, Faculty of Biology, Moscow State University M.V. Lomonosov . Scientific Director of the Laboratory of Experimental Immunology, Center for Molecular Biology and Biomedicine, Institute of Biology and Biomedicine, Nizhny Novgorod University N. N. Lobachevsky [1] . Included in the top 100 most cited Russian scientists.
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Biography
He graduated from the Second Mathematical School in 1969. Graduated from MIPT (Faculty of Molecular and Chemical Physics, Department of Molecular Biophysics). After graduating from MIPT in 1976, he worked in the Acad. Laboratory. G.P. Georgiev (until 1986) at the Institute of Molecular Biology named after Engelhardt RAS , then headed the scientific group and laboratory at the same Institute. At Moscow State University - since 1996 (A.N. Belozersky Institute of Physical and Chemical Biology). From 1995 to 2010 - International Research Scholar Medical Institute. Howard Hughes [2] .
In 1980, he defended his PhD, in 1990 - a doctoral dissertation. Since 1998, a professor. Head of the Laboratory of Molecular Mechanisms of Immunity, Institute of Molecular Biology, Russian Academy of Sciences V.A. Engelhardt.
He organized educational programs in oncoimmunology and molecular immunology in Moscow.
Member of the editorial boards of international and domestic journals: European Journal of Immunology, Journal of Inflammation, Immunology Letters, Molecular Biology, Russian Immunological Journal, Medical Immunology, Cytology.
As of February 1, 2016, it has 217 scientific publications; number of citations - more than 10,000; the Hirsch index is 49 [3] .
Married, has two children and two granddaughters.
Scientific activity
- Scientific interests
- mechanisms of innate immunity
- physiology of cytokines
- mouse genetic knockout and mouse models of human disease
- cancer antigens
S. A. Nedospasov made a major contribution to the development of domestic molecular biology, immunology and biomedicine. He and his school carried out pioneering work on the biology of cytokines, created unique animal models of human diseases, investigated the mechanisms of the pathogenesis of a number of diseases at the molecular level, developed new approaches to biotherapy, including the creation of prototypes of new drugs. S. A. Nedospasov published more than 200 articles, including in leading international journals (Science, Nature, Immunity, Blood, etc.). In the 80s, S. A. Nedospasov and colleagues were the first to molecularly clone the genes of cytokines of the family of tumor necrosis factor (TNF), which are mediators of immune processes. Based on these molecular clones, strains producing cytokines, including TNF and human lymphotoxin, were created in our country, and then a panel of monoclonal antibodies that neutralize their activity. S. A. Nedospasov and co-workers created a unique panel of mouse lines with controlled shutdown of the TNF, lymphotoxin and other mediators genes important for the development of the immune system. In these animals, it became possible to simulate various human diseases - from autoimmune and infectious to oncological, to study the relationship of microbiota with inflammation, and also to develop methods of biotherapy [4] .
Awards and Prizes
June 12, 2016
- Institute for Cancer Research Investigator Award (USA, 1991)
- Prize of the Berlin-Brandenburg Academy of Sciences (Germany, 2000)
- Helmholtz-Humboldt Prize (2005)
- Elected member of the European Academy (2010)., European Academy of Oncoimmunology (2012).
- Prize named after I.I. Mechnikov (2011) - For a series of scientific works “Molecular-Cellular Mechanisms of Organization of the Human and Mouse Lymphoid Organs” (jointly with A. A. Yarilin ).
- State Prize of the Russian Federation (2015) - for a cycle of fundamental and applied research on molecular immunity mediators, including work on the creation of unique biomedical models.
- Honorary Doctor of NNSU named after N. N. Lobachevsky (2016) [5]
Notes
- ↑ Archived copy (inaccessible link) . Date of treatment June 29, 2017. Archived June 29, 2017.
- ↑ Sergei A. Nedospasov, PhD, DSc | HHMI.org
- ↑ Biology: Top 100 most cited Russian scientists according to RSCI
- ↑ Scientists have created a prototype drug for arthritis and psoriasis
- ↑ S. A. Nedospasov became an honorary doctor of UNN
Links
- Profile of Sergei Arturovich Nedospasov on the official website of the RAS
- Personal page
- Help on the site Kremlin.ru
- Page in the system TRUE
- The page of the laboratory of molecular mechanisms of immunity on the website of the Institute of Molecular Biology V.A. Engelhardt, Russian Academy of Sciences
- The site of the educational program "Oncoimmunology"
- Site of the Department of Immunology, Faculty of Biology, Moscow State University
- The site of the laboratory of experimental immunology at Nizhny Novgorod State University. N. I. Lobachevsky