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Kotegov, Victor Petrovich

Victor Petrovich Kotegov (born May 13, 1955 , Molotov ) is a Russian pharmacologist , chemist , doctor of medical sciences (1997), professor (2001). Specialist in the experimental pharmacology of diabetes mellitus , inflammation , microelements, diseases of the central nervous system . Developer of drugs "Guacarben" and "Piron".

Victor Petrovich Kotegov
Victor Petrovich Kotegov, summer 2015.jpg
Date of BirthMay 13, 1955 ( 1955-05-13 ) ( aged 64)
Place of BirthMolotov
Scientific fieldpharmacology , chemistry
Place of workPerm Medical Institute , Perm Pharmaceutical Academy , Perm University
Alma materPerm Medical Institute
Academic degreeDoctor of Medical Sciences (1997)
Academic rankprofessor (2001)

Content

  • 1 Biography
  • 2 Scientific work
  • 3 Selected Works
  • 4 notes
  • 5 Sources and links
    • 5.1 References
    • 5.2 Video

Biography

Born in Perm . In 1979 he graduated from the medical faculty of the Perm Medical Institute .

In 1982 - 1990 - assistant, in 1990 - 1997 - senior lecturer, in 1997 - 2009 - professor, head of the department of pharmacology of the Perm Medical Institute [1] . Doctor of Medical Sciences ( 1997 ), Professor ( 2001 ).

In 2009 - 2012 - Professor, Head of the Department of Pharmacology, Perm Pharmaceutical Academy [2] .

In 2012 - 2014 - chief research fellow at the Department of Chemistry and Biotechnology of Perm University , since 2013 - professor, deputy. Head Department of Natural and Biologically Active Compounds [3] , chief researcher at the Laboratory of Experimental Pharmacology.

Since 2017 - Professor, Head of the Department of Pharmacology and Pharmacy, Perm University, Department of Pharmacology and Pharmacy // PSNIU .

Scientific work

He defended his thesis on the “Relationship between the structure and antidiabetic activity of guanidine derivatives” in 1983 at the Kazan Medical Institute. S.V. Kurashova . In 1997, at the Bashkir Medical University, he defended his doctoral dissertation "Antidiabetic activity of derivatives of aromatic sulfonates and carboxylic acids."

 

Since 1979, it has been organizing and performing preclinical trials of original and reproducible drugs, conducting studies of the general toxicity and specific activity of 130 drugs. One of the authors of the domestic antidiabetic drug glidifen (guacarbene) [4] , which, by order of the Ministry of Health of the Russian Federation No. 91 dated 03/31/1997, received permission for medical use.

In 2008 - 2012 , together with the Irkutsk Institute of Organic Chemistry named after Favorsky performed research under a grant from the Russian Academy of Sciences FNM-42 “New lipid-lowering, antihypoxic and anti-inflammatory drugs with improved characteristics based on polysaccharides”, section “Studying the gastrotoxicity of forms of piroxicam immobilized on polysaccharides in comparison with the substance of piroxicam”.

In 2011 - 2013 , he was the scientific director of the Cooperation Program of the Lausanne Polytechnic School (EPFL) , Perm Pharmaceutical Academy and Perm Polytechnic University in the field of diabetes and metabolic diseases research with the support of the Neva Charitable Foundation.

In 2013 - 2014 , he was the head of the RFBR grant “Electrochemical sensors based on selectively permeable sol-gel films for the analysis of biological markers”.

Since 2015, as the scientific director of pharmacological research, he has been carrying out scientific research under the state contract of August 28, 2015 No. 14.N08.12.1040 in the framework of the federal target program "Development of the pharmaceutical and medical industry of the Russian Federation for the period until 2020 and the future" " Preclinical studies of a non-steroidal anti-inflammatory drug based on (Z) -3- (2-oxo-2- (4-tolyl) ethylidene) piperazin-2-one for the treatment of osteoarthritis. " The working name of the drug is pyrone [5] .

Author of 290 scientific publications, 17 patents for invention. Supervises graduate students. Prepared 7 candidates of sciences.

Research interests include the experimental pharmacology of diabetes mellitus , inflammation , microelementoses, and diseases of the central nervous system . He is involved in modeling diabetes , dementia, behavioral and motor disorders, zinc-deficient conditions, and inflammation .

Member of the All-Russian Scientific Society of Pharmacologists.

Selected Works

  1. Kotegov V.P., Pleshakov M.G., Sachs A.S., Zuev A.P., Skachilova S. Ya. Synthesis and hypoglycemic activity of pyrrolidone-2 derivatives // Express Information. Series: Best Practices in the Chemical Pharmaceutical Industry. M. 1980.S. 38-40.
  2. Kotegov V.P., Aleshina V.A., Shramova Z. I., Zaks A.S., Hasanov S.G. Synthesis of glucophage antidiabetic analogues with improved pharmacological properties // Integrated development of synthetic drugs manufacturing technologies: collection of articles. scientific work. VNIHFI M. 1988. S. 106–111.
  3. Kotegov V.P., Voronin V.G., Shramova Z.I., Aleshina V.A., Pleshakov M.G., Zuev A.P. The biological activity of antipyrylbiguanides // Bull. All-Russian. scientific Center for Security Biol. active Substances: M. 1992. No. 2. P. 115–122.
  4. Kotegov V.P. Effect of glidifen on intestinal absorption of carbohydrates // Pediatric Gastroenterology of Siberia: Sat. scientific works to them. J. D. Vitebsky. Novosibirsk, Kurgan. 1998. Issue. 11. S. 34–39.
  5. Kotegov V.P., Pleshakov M.G., Sernov L.N., Sachs A.S., Korolchenko L.V., Snegotsky V.I. Guakarben - antidiabetic of a new chemical structure // Bulletin of the Scientific Center for the Safety of Biologically Active substances. Art. Kupavna. 1999. No. 1. S. 21–35.
  6. Kotegov V.P., Kolotova N.V., Dolzhenko A.V., Kozminykh V.O., Godina A.T. Substituted amides and hydrazides of 1,4-dicarboxylic acids. Communication 8. Synthesis and hypoglycemic activity of substituted amides and hydrazides of succinic acid // Chem. Journal. 1999. V. 33. No. 12. S. 9–11.
  7. Kotegov V.P., Godina A.T., Dolzhenko A.V. Screening of hypoglycemic compounds among amides and hydrazides of citraconic acid // Vestnik RSMU. M. 2000. No. 2 (12). S. 148.
  8. Kotegov V.P., Godina A.T., Dolzhenko A.V. Screening of hypoglycemic compounds among amides and succinic acid hydrazides // Bulletin of Russian State Medical University. M. 2000. No. 2 (12). S. 152.
  9. Kotegov V.P., Kolotova N.V., Kozminykh V.O., Dolzhenko A.V., Kozminykh E.N., Godina A.T. Substituted amides and hydrazides of dicarboxylic acids. Communication 9. Pharmacological activity of the products of the interaction of 2-aminopyridines and 2-aminopyrimidine with dicarboxylic acid anhydrides // Chem. Journal. 2001.Vol. 35. No. 3. P. 26-30.
  10. Kotegov V.P., Godina A.T., Dolzhenko A.V., Kozminykh V.O., Kolotova N.V. Hypoglycemic activity of the products of the interaction of o-phenylenediamine with cyclic anhydrides of some dicarboxylic acids // Herald of the Russian State Medical University. M. 2002. No. 1 (22). S. 125–126.
  11. Kotegov V.P., Godina A.T., Dolzhenko A.V., Kolotova N.V., Kozminykh V.O., Syropyatov B. Ya. Substituted amides and hydrazides of dicarboxylic acids. Message 10. Synthesis and pharmacological activity of substituted amides and hydrazides of succinic acid // Chem.-Pharm. Journal. 2002. Vol. 36. No. 2. P. 6–8.
  12. Kotegov V.P., Godina A.T., Dolzhenko A.V., Kolotova N.V., Kozminykh V.O., Syropyatov B. Ya. Substituted amides and hydrazides of dicarboxylic acids. Message 12. Synthesis, hypoglycemic and hypertensive activity of pyridylamides and some acylhydrazides of maleic and citraconic acids // Chem.-Pharm. Journal. 2002. Vol. 36. No. 4. P. 11–12.
  13. Kotegov VP, Dolzhenko AV, Kolotova NV, Kozminykh VO, Syropyatov B. Ya., Godina AT Hypoglycemic effect of several substituted amides and acylhydrazides of succinic acid // Pharmazie. 2002. V. 57. N.11. P.776–778.
  14. Kotegov V.P., Pavlova M.V., Mikhalev A.I., Konshin M.E., Vasilyuk M.V. Synthesis and anti-inflammatory activity of derivatives of isonicotinic and cichoninic acids // Chem.-Pharm. Journal. 2002. Vol. 36. No. 8. P. 27–28.
  15. Kotegov V.P., Dolzhenko-Podchezertseva A.V., Korkodinova L.M., Vasilyuk M.V. Synthesis and anti-inflammatory activity of N-acyl-5-bromoanthranilic acid amides // Chem. 2002. Vol. 36. No. 12. P. 12–13.
  16. Kotegov V.P., Godina A.T., Dolzhenko A.V., Kolotova N.V., Kozminykh V.O., Syropyatov B.Ya., Rudakova G.V. Substituted amides and hydrazides of dicarboxylic acids. Communication 13. Synthesis and hypoglycemic activity of certain substituted amides and acylhydrazides of phthalic acid // Chem.-Pharm. Journal. 2003. T. 37. No. 1. S. 21-23.
  17. Kotegov V.P., Ponomarenko E., Rudakova G.V., Godina A.T. Antidiabetic activity of o-derivatives of benzoic acid // Perm Medical Journal. 2003. V. 20. No. 2. S. 39–43.
  18. Kotegov V.P., Dolzhenko A.V., Kolotova N.V., Kozminykh V.O., Vasilyuk M.V., Novoselova G.N., Syropyatov B. Ya., Vakhrin M.I. Substituted amides and dicarboxylic acid hydrazides. Message 14. Synthesis, antimicrobial and anti-inflammatory activity of 4-antipyrylamides, 2-thiazolylamides and 1-triazolylamides of some dicarboxylic acids // Chem.-Pharm. Journal. 2003.V. 37. No. 3. S. 42–44.
  19. Kotegov V.P., Dolzhenko A.V., Kolotova N.V., Kozminykh V.O., Syropyatov B.Ya., Godina A.T., Rudakova G.V. Substituted amides and hydrazides of dicarboxylic acids. Message 15. Synthesis and hypoglycemic activity of certain amides and acylhydrazides of tetrachlorophthalic acid // Chem.-Pharm. Journal. 2003.V. 37. No. 4. S. 24-26.
  20. Kotegov V.P., Dolzhenko A.V., Kozminykh V.O., Kolotova N.V., Burdi N.Z., Novoselova G.N., Syropyatov B. Ya. Substituted amides and hydrazides of dicarboxylic acids. Communication 17. Synthesis and study of the antibacterial and anticonvulsant activity of certain substituted amides and acyl hydrazides of phthalic acid // Chem. Pharm. Journal. 2003.V. 37. No. 7. S. 7–9.
  21. Kotegov V.P., Dolzhenko A.V., Godina A.T., Syropyatov B. Ya., Kolotova N.V., Kozminykh V.O. Study of hypoglycemic activity of some substituted amides and succinic acid hydrazides // Experimental and Clinical pharmacology. 2003.V. 66. No. 3. S. 36–38.
  22. Kotegov V.P., Dolzhenko-Podchezertseva A.V., Korkodinova L.M., Vizgunova O. L., Vasilyuk M.V. Synthesis and anti-inflammatory activity of new N-acyl-5-bromoanthranilamides // Chem. Journal. 2004.V. 38. No. 8. S. 27–28.
  23. Kotegov V.P., Dolzhenko A.V., Kolotova N.V., Syropyatov B.Ya., Vasilyuk M.V., Rudakova G.V., Novikova V.V., Feshin V.P. Synthesis and biological activity of some substituted tetrachlorophthalic acid monoamides // Chem. 2005.Vol. 39. No. 8. S. 16–18.
  24. Kotegov V.P., Russians V.A., Kolotova N.V., Dolzhenko A.V. Antidiabetic activity of succinic acid 4-aminobenzoylhydrazide // Perm Medical Journal. 2006.V. 33. No. 4. P. 6-14.
  25. Kotegov V.P., Alikina N.A. Influence of piracetam on experimental convulsions // Bulletin of the Peoples' Friendship University of Russia. Series Medicine. 2009. No4. S. 330–331.
  26. Kotegov V.P., Ponomarenko E.V. Experimental study of antiatherogenic properties of guacarbene // Bulletin of the Peoples' Friendship University of Russia. Series Medicine. 2009. No4. S. 245-247.
  27. Kotegov V.P., Alikina N.A., Tregubov A. L. Change in anticonvulsant activity of anticonvulsants under the influence of psychotropic drugs according to the maximum electric shock test // Experimental and Clinical Pharmacology. 2010.V. 73. No. 8. S. 6–9.
  28. Kotegov V.P., Kolotova N.I., Bulatov I.P., Bludova M. Yu., Pestov G.N., Andreev A.I. Experimental study of the antidiabetic activity of 4-aminobenzoylhydrazide succinic acid // Bulletin of Siberian medicine. 2011. V. 10. No. 5. S. 66–69
  29. Kotegov V.P., Suldin A.V., Lipina M.V., Ivanova N.A. Hypoglycemic activity of chelated complexes of zinc with amino acids // Microelements in medicine. 2011. Vol. 12. No. 3-4. S. 83–85.
  30. Kotegov V.P., Skalny A.V., Brudastov Yu.A., Suldin A.V., Malkova Ya. G. Experimental study of the effect of zinc sulfate on carbohydrate tolerance, hypoglycemic effect of insulin and ethanol toxicity // Questions of biological, medical and pharmaceutical chemistry. 2012. No.6. S. 63–67.
  31. Kotegov V.P., Kirikov A. Yu., Igidov N.M., Goldstein A.G., Makhmudov R.R. Synthesis and biological activity of amides and esters 2- [1,5-dimethyl-3-oxo-2 -phenyl-2,3-dihydro-1H-pyrazol-4-yl] amino-5,5-dimethyl-4-oxohex-2-enoic acid // Scientific reports of Belgorod State University. The medicine. Pharmacy. 2012. No.16 (135). Issue 19. P. 119–122.
  32. Kotegov V.P., Malkova T.L., Mashchenko P.S., Bulatov I.P.Creation of centers for the study of new psychoactive substances in the fight against drug addiction // Quality management in the field of health and social development. 2012. No2. S. 99-102.
  33. Kotegov V.P., Kirikov A. Yu., Igidov N.M., Bulatov I.P. Synthesis and hypoglycemic activity of amides and salts of 2-heterylamino derivatives of 5,5-dimethyl-4-oxo-2-hexenoic acids // Modern problems of science and education. 2013. No2.
  34. Kotegov V.P., Levandovskaya E. B., Fedorova N. L., Bobyleva A. A., Gein V. L., Razumova M. Yu., Syropyatov B. Ya. Search for compounds with hypoglycemic activity, among 1 -alkoxyalkyl- (alkoxyaryl) substituted 3-hydroxy-3-pyrrolin-2-ones and their amino derivatives // Fundamental Studies . 2013. No. 6–4 . S. 935–938.
  35. Kotegov VP, Andreev AI, Bulatov IP, Malkova TL, Zykova SS, Maschenko PS The Study of behavioural modification of stress responses at the mice exposed by JWH-250. Autoecological aspects // World Applied Sciences Journal . 2013.V. 27. No. 9 . P. 1091-1097.
  36. Kotegov VP, Andreev AI, Bulatov IP, Malkova TL, Zykova SS, Maschenko PS The Study of behavioural modification of stress responses at the mice exposed by JWH-250. Autoecological aspects. Part 2 // Middle East Journal of Scientific Research . 2013. Vol. 18. No. 3. P. 352–358.
  37. Kotegov V.P., Andreev A.I., Pestov G.N., Malkova Ya. G., Razumova M. Yu. Experimental study of the general toxicity of Zhivitsa Asset oil 1. Effect of Zhivitsa Asset oil on the dynamics of body weight , the state of the central nervous system and kidneys of rats // Family Health - 21 century. 2014. No3. S. 66–76.
  38. Kotegov V.P., Medvedeva A.S., Safronova L.P., Ganenko T.V., Sukhov B.G., Larina L.I., Konshina T.M. Preparation of a water-soluble bioconjugate piroxicam-arabinogalactan sulfate // News of the Academy of Sciences. Chemical series. 2014. No. 9. P. 2136–2141.
  39. Kotegov V.P., Kurbatov E.R., Chupina T.A., Korkodinova L.M., Vlasova N.A., Vizgunova O. L. Hypoglycemic activity of substituted amides of halogenanthranilic acids // Chem. Journal. 2014.V. 48. No. 10. P. 37–38.
  40. Kotegov V.P., Suldin A.V., Andreev A.I., Pestov G.N., Malkova Ya. G., Razumova M. Yu. Experimental study of the general toxicity of Zhivitsa Asset oil 2. Effect of Zhivitsa oil asset ”on the state of peripheral blood formation and metabolism of rats // Family Health - 21 century. 2014. No4. S. 85–96.
  41. Kotegov V.P., Bulatov I.P., Suldin A.V., Pucnina S.V., Suldin A.S., Kolotova N.V. Choice of the optimal composition of sustained-release para-aminobenzoylhydrazide succinic acid tablets // Modern Problems science and education . 2015. No. 2–3 . S. 246.
  42. Kotegov V.P., Mashevskaya I.V. , Pestov G.N., Markova L.N., Pchelintseva D.I., Pavlov P.T. Synthesis and antidiabetic activity of the products of the interaction of 3-aroylpyrrolo [1,2-A ] quinoxaline-1,2,4 (5H) -trions with a number of Gevald's thiophenes // Bulletin of Perm University. Series: Chemistry . 2015. No4 . S. 66–77.
  43. Kotegov V.P., Geyn V.L., Zamaraeva T.M., Mishunin V.V. Synthesis and hypoglycemic activity of methyl-6-aryl (heteryl) -5- (2-furanoyl) -3,6-dihydrotetrazolo- [1,5-A] pyrimidine-4-carboxylates // Journal of General Chemistry . 2016.V. 86. No. 2 . S. 258–262.

Notes

  1. ↑ Department of Pharmacology // Perm State Medical University .
  2. ↑ History of the Department of Pharmacology // Perm State Pharmaceutical Academy .
  3. ↑ Department of Natural and Biologically Active Compounds // PGNIU .
  4. ↑ Proynova V.A., Rozhnov G.I., Pleshakov M.G., Kotegov V.P. Glidifen. Guanidinium salt of 2,4-dichloro-5-carboxy-benzenesulfonic acid, diaphen // Toxicological Bulletin. 2008. N 4.
  5. ↑ Suvorova N. Molecule synthesized at PSNIU will become the basis of a new generation of medicine // Russian newspaper . 12/04/2015.

Sources and links

Links

  • History of the Department of Pharmacology // Perm State Pharmaceutical Academy .
  • Department of Pharmacology // Perm State Medical University .
  • Kotegov Victor Petrovich (inaccessible link) // Map of Russian science .
  • Patents of the author Kotegov Victor Petrovich // Findpatent.ru.
  • Perm University will develop a drug for the treatment of osteoarthritis // Pharmaceutical Bulletin. 11/06/2015.
  • Perm University received federal support for the creation of a drug for the treatment of diabetes mellitus (video) // Official website of PSNIU . 10/27/2016.
  • Suvorova N. Molecule synthesized at PSNIU will become the basis of a new generation of medicine // Rossiyskaya Gazeta . 12/04/2015.
  • Cherepanov M. Victor Kotegov: medicines are shrapnel that strikes the body’s systems // In the course. Permian. 11/23/2015.
  • Cherepanov M. The world rests on tablets: Victor Kotegov about the characteristics of the pharmaceutical market // Perm Tribune. 11/23/2015.

Video

  • The cure for osteoarthritis // RifeyTV . 10/28/2015.
Source - https://ru.wikipedia.org/w/index.php?title=Kotegov__Viktor_Petrovich&oldid=95458578


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