Flamin (medicine)

There are two forms of the drug: adult and children. Flamin in the dosage for adults is available in the form of round tablets of light yellow, gray-yellow or brown color with a small amount of inclusions.

Flamin for children is available in the form of light yellow or grayish yellow color of irregularly shaped granules . A suspension is prepared from the granules for oral administration.

Both forms of the drug have a weak peculiar smell inherent in the dry grass of immortelle sandy.

The drug belongs to the choleretic means of plant origin. The composition of the granules is the active ingredient - extract of flowers of immortelle sandy, which contains a rich set of flavonoids (salipurpozid, naringenin, apigenin, kaempferol and their glycosides ), bitter and tannins , triterpene saponins , phytosterol sitosterol, essential oil , organic acids (including , ascorbic), carotenoids , polysaccharides , vitamin K and chalcone isosalipuroside.

For the formation of tablets used excipients:

• Milk sugar (lactose monohydrate);
• Corn starch;
• Magnesium carbonate basic (magnesium hydroxycarbonate);
• Calcium stearate.

For the formation of granules used excipients:

• Pectin ;
• Citric acid monohydrate ;
• Sorbic acid;
• Sucrose .

Choleretic and other actions of the drug are based on the amount of active substances contained in the extract of flowers of the immortelle sand. Flavonoids enhance the secretion of bile , as well as gastric and pancreatic juices (stimulate the excretory activity of the pancreas ) necessary for digestion. They increase the tone of the gallbladder, thereby increasing the outflow of bile, and also act as a spasmolytic on the smooth muscles of the sphincter of the bile ducts and bladder. At the same time, these substances slow down intestinal motility, which contributes to a better digestion and assimilation of food.

The cumulative effect changes the viscosity and chemical composition of bile ^[1] , increases the cholera cholesterol coefficient (that is, increases the bilirubin content in it and the release of cholesterol with it ^[2] ). In addition, flavonoids have the ability to expand blood vessels. In this case, the intestines and other organs of the digestive system.

The antibacterial effect of the drug is directed against gram-positive bacteria - streptococci and staphylococci, rod-shaped bacteria. The antiparasitic effect of sandy immortelle extract is associated with the presence of resin (diterpenic) acids in it.

Flamin is used in combination with other therapeutic agents or singly, is used in the presence of diseases:

• Hepatitis ^[3] ;
• Chronic hepatocholecystitis;
• Cholecystitis ;
• Biliary dyskinesia ^[4] ;
• Giardiasis ;
• Ulcerative colitis ^[5] .

Flamin for children is indicated for use by infants from the first month of life ^[6] . The adult form of the drug is prescribed to patients from the age of 12.

Contraindications are divided into absolute and relative.

Absolute contraindications are:

• Obstructive jaundice ;
• Sucrose / isomaltase deficiency;
• Congenital fructose intolerance;
• Glucose-galactose malabsorption ;
• Hypersensitivity to the components (the drug is low toxic, so allergic reactions are extremely rare);
• Infant age up to 1 month.

Relative contraindications are:

• Diabetes mellitus ;
• Low carbohydrate diet;
• Hypertension ;
• Gallstone disease ;
• Pregnancy and lactation.

Flamin tablets are taken orally, 1 tablet 3 times a day, half an hour before meals, with a large amount of water. Flamin for children should be taken as a suspension . To prepare the suspension, dilute the required amount of granules into 20-50 ml of boiled water at room temperature.

The dosage is prescribed depending on the age of the child:

1 month - 12 months: 1 package per day; 12 months - 36 months: 2 packages per day; 4 - 5 years: 3 packages per day; 5 - 12 years: 4 packages per day.

Taking the drug course, 3 times a day for half an hour before meals. The minimum course of treatment is 10 days. The duration of treatment should not exceed 40 days.

The flavonoids in the composition increase the antiparasitic activity of certain drugs: metronidazole (trichopol) and aminoquinol in the treatment of giardiasis.

• Allergic reactions (discoloration of the skin, rash, fever, nausea and other dyspeptic reactions );
• Increased blood pressure in the presence of hypertension.

When these symptoms occur, discontinue use of the drug and take symptomatic treatment. Prolonged use of the drug can cause stagnation in the liver .

The shelf life of the prepared suspension at a temperature not exceeding + 7 ° C shall not exceed 10 days. The total shelf life of the drug is 2 years. Storage should be carried out in a dark place at a temperature not higher than + 25 ° C.

Choleretic drugs

Flamin for children in the State Register of Medicines Flamin (tablets) in the State Registry of Medicines