Apolipoprotein L1 (apoL; English apolipoprotein L1, apoL1 ) is a minor plasma apolipoprotein , which is part of high density lipoproteins and is always associated with apoA1 . Identified by one of the latter in the apolipoprotein group. Presented not only in the blood, but also in the central nervous system along with apoE . The role of protein is unknown.
| Apolipoprotein L1 | |
|---|---|
| Designations | |
| Characters | Apol |
| Entrez gene | 8542 |
| Hgnc | 618 |
| Omim | 607254 |
| Refseq | NM_001646 |
| Uniprot | O14791 |
| Other data | |
| Locus | 22nd hr , 22q12.3 |
Gene and protein
ApoL is expressed in many tissues ( lungs , pancreas , prostate , liver , spleen and placenta ). It is characterized by high expression in the central nervous system (as well as apoE and apoD ). There are 6 apoL isoforms (apoL 1-6), each represented by its own gene. All genes are on chromosome 22 .
The protein belongs to amphipathic proteins, that is, it is a true apolipoprotein, molecular weight 42 kDa. 12 alternative splicing products of 6 apoL isoforms were detected. [one]