Lecithin cholesterol acyltransferase , or phosphatidylcholinerol O-transferase (LHAT, EC 2.3.1.43 , English Lecithin-cholesterol acyltransferase, LCAT ) is an enzyme that converts free high-density lipoprotein cholesterol to cholesterol esters , which are more hydrophobic, and are more hydrophobic.
| Lecithin cholesterol acyltransferase | |
|---|---|
| Designations | |
| Characters | LCAT |
| Entrez gene | 3931 |
| Hgnc | 6522 |
| Omim | 606967 |
| Refseq | NM_000229 |
| Uniprot | P04180 |
| Other data | |
| Cipher cf | 2.3.1.43 |
| Locus | 16th , 16q22.1 |
Content
Role
LHAT is an enzyme of lipoprotein metabolism. LHAT is associated with the surface of high density lipoproteins that contain apolipoprotein A1 , an activator of this enzyme. Due to its high hydrophobicity, cholesterol converted into cholesterol esters moves from the surface of the lipoprotein to the nucleus, freeing up space on the surface of the particle to capture new free cholesterol. Thus, this reaction is extremely important for the process of purification of peripheral tissues from cholesterol ( reverse cholesterol transport ). The HDL particle as a result increases in diameter or, in the case of nascent HDL, is transformed from a disk-shaped to spherical.
LHAT deficiency
LHAT deficiency is a recessive hereditary metabolic disease caused by a violation of the enzyme gene . It is characterized by the accumulation of cholesterol in the body. With a complete violation of the activity of LHAT, corneal opacity, proteinuria, and renal failure develop. With partial insufficiency, only clouding of the cornea develops (the so-called fish-eye disease).
See also
- High density lipoproteins
- Apolipoprotein A1
- Apolipoprotein A4
- Cholesterol Reverse Transport
Links
- Dobiásová M., Frohlich J. Advances in understanding of the role of lecithin cholesterol acyltransferase (LCAT) in cholesterol transport. (English) // Clin Chim Acta : journal. - 1999. - Vol. 286 , no. 1-2 . - P. 257—271 .