Mad2l2

Mitotic deficient blocker MAD2 2 (yeast)
	; Presented based on PDB .
Available Structures
PDB	Ortholog Search: PDBe , RCSB
PDB ID List
	, , , , ,
Identifiers
Symbol	; MAD2B; POLZ2; REV7
External IDs	GeneCards :
Gene ontology
Function	•; •; •;
Cell component	•; •; •; •; •; •;
Biological process	•; •; •; •; •; •; •; •; •; •; •; •; •; •; •; •; •; •; •;
	Sources: Amigo / QuickGO
Orthologists

The protein of the mitotic control point of the assembly of the spindle of division MAD2B is a protein encoded in humans by the MAD2L2 gene ^[1] ^[2] .

Content

Function

MAD2L2 is a component of the mitotic control point of the fission spindle assembly, which prevents the occurrence of anaphase until all chromosomes are correctly aligned on the metaphase plate. MAD2L2 is a homologue of MAD2L1 ^[2] .

Interactions

MAD2L2 has been found to interact with:

^[3] ,
MAD2L1 ^[4] ,
^[5] and
^[5] ^[4] .

Notes

↑ Cahill DP, da Costa LT, Carson-Walter EB, Kinzler KW, Vogelstein B., Lengauer C. Characterization of MAD2B and other mitotic spindle checkpoint genes (Eng.) // Genomics : journal. - Academic Press , 1999 .-- August ( vol. 58 , no. 2 ). - P. 181-187 . - DOI : 10.1006 / geno.1999.5831 . - PMID 10366450 .
↑ ¹ ² Entrez Gene: MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) (neopr.) .
↑ Nelson KK, Schlöndorff J., Blobel CP Evidence for an interaction of the metalloprotease-disintegrin tumor necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein , MAD2beta (Eng.) // Biochem. J. : journal. - 1999 .-- November ( vol. 343 , no. 3 ). - P. 673-680 . - DOI : 10.1042 / 0264-6021: 3430673 . - PMID 10527948 .
↑ ¹ ² Murakumo Y., Roth T., Ishii H., Rasio D., Numata S., Croce CM, Fishel R. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 ( English) // J. Biol. Chem. : journal. - 2000 .-- February ( vol. 275 , no. 6 ). - P. 4391-4397 . - DOI : 10.1074 / jbc.275.6.4391 . - PMID 10660610 .
↑ ¹ ² Murakumo Y., Ogura Y., Ishii H., Numata S., Ichihara M., Croce CM, Fishel R., Takahashi M. Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7 .) // J. Biol. Chem. : journal. - 2001 .-- September ( vol. 276 , no. 38 ). - P. 35644-35651 . - DOI : 10.1074 / jbc.M102051200 . - PMID 11485998 .

Literature

Nelson KK, Schlöndorff J., Blobel CP Evidence for an interaction of the metalloprotease-disintegrin tumor necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta (Eng.) // Biochem. J. : journal. - 1999. - Vol. 343 , no. 3 . - P. 673-680 . - DOI : 10.1042 / 0264-6021: 3430673 . - PMID 10527948 .
Murakumo Y., Roth T., Ishii H., Rasio D., Numata S., Croce CM, Fishel R. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 // J. Biol. Chem. : journal. - 2000. - Vol. 275 , no. 6 . - P. 4391-4397 . - DOI : 10.1074 / jbc.275.6.4391 . - PMID 10660610 .
Chan SH, Hung FS, Chan DS, Shaw PC Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2B (Eng.) // Eur. J. Biochem. : journal. - 2001. - Vol. 268 , no. 7 . - P. 2107-2112 . - DOI : 10.1046 / j.1432-1327.2001.02091.x . - PMID 11277934 .
Chen J., Fang G. MAD2B is an inhibitor of the anaphase-promoting complex (Eng.) // Genes Dev. : journal. - 2001. - Vol. 15 , no. 14 . - P. 1765-1770 . - DOI : 10.1101 / gad . 898701 . - PMID 11459826 .
Murakumo Y., Ogura Y., Ishii H., Numata S., Ichihara M., Croce CM, Fishel R., Takahashi M. Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7 / / J. Biol. Chem. : journal. - 2001. - Vol. 276 , no. 38 . - P. 35644-35651 . - DOI : 10.1074 / jbc.M102051200 . - PMID 11485998 .
Weterman MA, van Groningen JJ, Tertoolen L., van Kessel AG Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t (X; 1) -positive renal cell carcinomas (Eng.) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 2001. - Vol. 98 , no. 24 . - P. 13808-13813 . - DOI : 10.1073 / pnas . 241304198 . - PMID 11717438 .
Masuda Y., Ohmae M., Masuda K., Kamiya K. Structure and enzymatic properties of a stable complex of the human REV1 and REV7 proteins (Eng.) // J. Biol. Chem. : journal. - 2003. - Vol. 278 , no. 14 . - P. 12356-12360 . - DOI : 10.1074 / jbc.M211765200 . - PMID 12529368 .
Ying B., Wold WS Adenovirus ADP protein (E3-11.6K), which is required for efficient cell lysis and virus release, interacts with human MAD2B (Eng.) // Virology: journal. - 2003. - Vol. 313 , no. 1 . - P. 224-234 . - DOI : 10.1016 / S0042-6822 (03) 00287-3 . - PMID 12951035 .
Lehner B., Semple JI, Brown SE, Counsell D., Campbell RD, Sanderson CM Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region .) // Genomics : journal. - Academic Press , 2004. - Vol. 83 , no. 1 . - P. 153-167 . - DOI : 10.1016 / S0888-7543 (03) 00235-0 . - PMID 14667819 .
Ohashi E., Murakumo Y., Kanjo N., Akagi J., Masutani C., Hanaoka F., Ohmori H. Interaction of hREV1 with three human Y-family DNA polymerases (Eng.) // Genes Cells : journal. - 2004. - Vol. 9 , no. 6 . - P. 523-531 . - DOI : 10.1111 / j.1356-9597.2004.00747.x . - PMID 15189446 .
Rual JF, Venkatesan K., Hao T., Hirozane-Kishikawa T., Dricot A., Li N., Berriz GF, Gibbons FD, Dreze M., Ayivi-Guedehoussou N., Klitgord N., Simon C., Boxem M., Milstein S., Rosenberg J., Goldberg DS, Zhang LV, Wong SL, Franklin G., Li S., Albala JS, Lim J., Fraughton C., Llamosas E., Cevik S., Bex C. , Lamesch P., Sikorski RS, Vandenhaute J., Zoghbi HY, Smolyar A., Bosak S., Sequerra R., Doucette-Stamm L., Cusick ME, Hill DE, Roth FP, Vidal M. Towards a proteome-scale map of the human protein-protein interaction network (eng.) // Nature: journal. - 2005. - Vol. 437 , no. 7062 . - P. 1173-1178 . - DOI : 10.1038 / nature04209 . - PMID 16189514 .
Rimkus C., Friederichs J., Rosenberg R., Holzmann B., Siewert JR, Janssen KP Expression of the mitotic checkpoint gene MAD2L2 has prognostic significance in colon cancer (English) // Int. J. Cancer : journal. - 2007. - Vol. 120 , no. 1 . - P. 207-211 . - DOI : 10.1002 / ijc.22155 . - PMID 17044027 .
Zhang L., Yang SH, Sharrocks AD Rev7 / MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1 (Eng.) // Mol. Cell. Biol. : journal. - 2007. - Vol. 27 , no. 8 . - P. 2861-2869 . - DOI : 10.1128 / MCB.02276-06 . - PMID 17296730 .
Pinto M., Soares MJ, Cerveira N., Henrique R., Ribeiro FR, Oliveira J., Jerónimo C., Teixeira MR Expression changes of the MAD mitotic checkpoint gene family in renal cell carcinomas characterized by numerical chromosome changes // Virchows Arch. : journal. - 2007. - Vol. 450 , no. 4 . - P. 379-385 . - DOI : 10.1007 / s00428-007-0386-7 . - PMID 17333263 .

[pmid10366450-1] Cahill DP, da Costa LT, Carson-Walter EB, Kinzler KW, Vogelstein B., Lengauer C. Characterization of MAD2B and other mitotic spindle checkpoint genes (Eng.) // Genomics : journal. - Academic Press , 1999 .-- August ( vol. 58 , no. 2 ). - P. 181-187 . - DOI : 10.1006 / geno.1999.5831 . - PMID 10366450 .

[entrez-2] ¹ ² Entrez Gene: MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) (neopr.) .

[pmid10527948-3] Nelson KK, Schlöndorff J., Blobel CP Evidence for an interaction of the metalloprotease-disintegrin tumor necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein , MAD2beta (Eng.) // Biochem. J. : journal. - 1999 .-- November ( vol. 343 , no. 3 ). - P. 673-680 . - DOI : 10.1042 / 0264-6021: 3430673 . - PMID 10527948 .

[pmid10660610-4] ¹ ² Murakumo Y., Roth T., Ishii H., Rasio D., Numata S., Croce CM, Fishel R. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 ( English) // J. Biol. Chem. : journal. - 2000 .-- February ( vol. 275 , no. 6 ). - P. 4391-4397 . - DOI : 10.1074 / jbc.275.6.4391 . - PMID 10660610 .

[pmid11485998-5] ¹ ² Murakumo Y., Ogura Y., Ishii H., Numata S., Ichihara M., Croce CM, Fishel R., Takahashi M. Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7 .) // J. Biol. Chem. : journal. - 2001 .-- September ( vol. 276 , no. 38 ). - P. 35644-35651 . - DOI : 10.1074 / jbc.M102051200 . - PMID 11485998 .