COUP-TFII ( transcription factor COUP 2 ), also known as NR2F2 (subfamily of nuclear receptors 2, group F, element 2) is a protein encoded in humans by the NR2F2 gene [1] [2] . The acronym COUP stands for chicken ovalbumin upstream promoter , the upstream chicken ovalbumin promoter.
| Member of the 2nd subfamily of nuclear receptors of group 2 F | |||||||||||||
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| Symbol | ; ARP1; CHTD4; COUPTFB; COUPTFII; NF-E3; NR2F1; SVP40; TFCOUP2 | ||||||||||||
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Function
COUP-TFII plays an important role in the regulation of the development of a number of tissues and organs, including the heart, blood vessels, muscles, and limbs [3] [4] .
Glucocorticoid receptors stimulate COUP-TFII-mediated gene transactivation, and COUP-TFII itself inhibits the transcriptional activity of glucocorticoid receptors [5] [6] . COUP-TFII interacts with GATA2 , inhibiting adipocyte differentiation [7] .
Interactions
COUP-TFII. Has been shown to interact with:
- HDAC1 [8]
- Lck [9]
- NR2F6 [10]
- Nucleolin [11]
Notes
- ↑ Entrez Gene: NR2F2 nuclear receptor subfamily 2, group F, member 2 .
- ↑ Qiu Y., Krishnan V., Zeng Z., Gilbert DJ, Copeland NG, Gibson L., Yang-Feng T., Jenkins NA, Tsai MJ, Tsai SY Isolation, characterization, and chromosomal localization of mouse and human COUP- TF I and II genes (Eng.) // Genomics : journal. - Academic Press , 1995 .-- September ( vol. 29 , no. 1 ). - P. 240-246 . - DOI : 10.1006 / geno.1995.1237 . - PMID 8530078 .
- ↑ Pereira FA, Qiu Y., Zhou G., Tsai MJ, Tsai SY The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development (Eng.) // Genes & Development : journal. - 1999 .-- April ( vol. 13 , no. 8 ). - P. 1037-1049 . - DOI : 10.1101 / gad.13.8.1037 . - PMID 10215630 .
- ↑ Lee CT, Li L., Takamoto N., Martin JF, Demayo FJ, Tsai MJ, Tsai SY The Nuclear Orphan Receptor COUP-TFII Is Required for Limb and Skeletal Muscle Development (Eng.) // Molecular and Cellular Biology : journal. - 2004 .-- December ( vol. 24 , no. 24 ). - P. 10835-10843 . - DOI : 10.1128 / MCB.24.24.10835-10843.2004 . - PMID 15572686 .
- ↑ De Martino MU, Bhattachryya N., Alesci S., Ichijo T., Chrousos GP, Kino T. The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism (Eng.) // Molecular Endocrinology : journal. - 2004 .-- April ( vol. 18 , no. 4 ). - P. 820-833 . - DOI : 10.1210 / me.2003-0341 . - PMID 14739255 .
- ↑ De Martino MU, Alesci S., Chrousos GP, Kino T. Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism (Eng.) // Annals of the New York Academy of Sciences : journal. - 2004 .-- June ( vol. 1024 ). - P. 72-85 . - DOI : 10.1196 / annals.1321.006 . - PMID 15265774 .
- ↑ Xu Z., Yu S., Hsu CH, Eguchi J., Rosen ED The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis (English) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 2008 .-- February ( vol. 105 , no. 7 ). - P. 2421-2426 . - DOI : 10.1073 / pnas.0707082105 . - PMID 18250317 .
- ↑ Smirnov DA, Hou S., Ricciardi RP Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription (Eng.) // Virology: journal. - 2000 .-- March ( vol. 268 , no. 2 ). - P. 319—328 . - DOI : 10.1006 / viro.1999.0181 . - PMID 10704340 .
- ↑ Marcus SL, Winrow CJ, Capone JP, Rachubinski RA A p56 (lck) ligand serves as a coactivator of an orphan nuclear hormone receptor (Eng.) // Journal of Biological Chemistry : journal. - 1996 .-- November ( vol. 271 , no. 44 ). - P. 27197-27200 . - DOI : 10.1074 / jbc.271.44.27197 . - PMID 8910285 .
- ↑ Avram D., Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P., Leid M. Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2 // Journal of Biological Chemistry : journal. - 1999 .-- May ( vol. 274 , no. 20 ). - P. 14331-14336 . - DOI : 10.1074 / jbc.274.20.14331 . - PMID 10318855 .
- ↑ Litchfield LM, Riggs KA, Hockenberry AM, Oliver LD, Barnhart KG, Cai J., Pierce WM, Ivanova MM, Bates PJ, Appana SN, Datta S., Kulesza P., McBryan J., Young LS, Klinge CM Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells. (English) // PLoS ONE : journal. - 2012 .-- May ( vol. 7 , no. 5 ). - DOI : 10.1371 / journal.pone.0038278 . - PMID 22693611 .
Literature
- De Martino MU, Alesci S., Chrousos GP, Kino T. Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism ( Eng.) // Annals of the New York Academy of Sciences : journal. - 2004. - Vol. 1024 . - P. 72-85 . - DOI : 10.1196 / annals.1321.006 . - PMID 15265774 .
- Mietus-Snyder M., Sladek FM, Ginsburg GS, Kuo CF, Ladias JA, Darnell JE, Karathanasis SK Antagonism between apolipoprotein AI regulatory protein 1, Ear3 / COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells (Eng.) // Molecular and Cellular Biology : journal. - 1992. - Vol. 12 , no. 4 . - P. 1708-1718 . - PMID 1312668 .
- Wang LH, Ing NH, Tsai SY, O'Malley BW, Tsai MJ The COUP-TFs compose a family of functionally related transcription factors (Eng.) // Gene Expr. : journal. - 1992. - Vol. 1 , no. 3 . - P. 207-216 . - PMID 1820218 .
- Ladias JA, Karathanasis SK Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily (Eng.) // Science: journal. - 1991. - Vol. 251 , no. 4993 . - P. 561-565 . - DOI : 10.1126 / science.1899293 . - PMID 1899293 .
- Marcus SL, Winrow CJ, Capone JP, Rachubinski RA A p56 (lck) ligand serves as a coactivator of an orphan nuclear hormone receptor (Eng.) // Journal of Biological Chemistry : journal. - 1996. - Vol. 271 , no. 44 . - P. 27197-27200 . - DOI : 10.1074 / jbc.271.44.27197 . - PMID 8910285 .
- Thénot S., Henriquet C., Rochefort H., Cavaillès V. Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1 (Eng.) // Journal of Biological Chemistry : journal. - 1997. - Vol. 272 , no. 18 . - P. 12062-12068 . - DOI : 10.1074 / jbc.272.18.12062 . - PMID 9115274 .
- Chu K., Zingg HH The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter (Eng.) // Journal of Molecular Endocrinology : journal. - 1998. - Vol. 19 , no. 2 . - P. 163-172 . - DOI : 10.1677 / jme.0.0190163 . - PMID 9343308 .
- Bailey P., Sartorelli V., Hamamori Y., Muscat GE The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD / / Nucleic Acids Research : journal. - 1999. - Vol. 26 , no. 23 . - P. 5501–5510 . - DOI : 10.1093 / nar / 26.23.5501 . - PMID 9826778 .
- Avram D., Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P., Leid M. Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2 // Journal of Biological Chemistry : journal . - 1999. - Vol. 274 , no. 20 . - P. 14331-14336 . - DOI : 10.1074 / jbc.274.20.14331 . - PMID 10318855 .
- Smirnov DA, Hou S., Ricciardi RP Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription // English . - 2000. - Vol. 268 , no. 2 . - P. 319—328 . - DOI : 10.1006 / viro.1999.0181 . - PMID 10704340 .
- Avram D., Fields A., Pretty On Top K., Nevrivy DJ, Ishmael JE, Leid M. Isolation of a Novel Family of C2H2 Zinc Finger Proteins Implicated in Transcriptional Repression Mediated by Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Orphan Nuclear Receptors (English) // Journal of Biological Chemistry : journal. - 2000. - Vol. 275 , no. 14 . - P. 10315-10322 . - DOI : 10.1074 / jbc.275.14.14.10315 . - PMID 10744719 .
- Jordan EM, Worley T., Breen GA Transcriptional regulation of the nuclear gene encoding the alpha-subunit of the mammalian mitochondrial F1F0 ATP synthase complex: role for the orphan nuclear receptor, COUP-TFII / ARP-1 (Eng.) // Biochemistry : journal. - 2003. - Vol. 42 , no. 9 . - P. 2656-2663 . - DOI : 10.1021 / bi0268347 . - PMID 12614160 .
- Sato Y., Suzuki T., Hidaka K., Sato H., Ito K., Ito S., Sasano H. Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein / steroidogenic factor-1 immunolocalization during the menstrual cycle (eng.) // The Journal of Clinical Endocrinology and Metabolism : journal. - 2003. - Vol. 88 , no. 7 . - P. 3415—3420 . - DOI : 10.1210 / jc.2002-021723 . - PMID 12843196 .
- Colland F., Jacq X., Trouplin V., Mougin C., Groizeleau C., Hamburger A., Meil A., Wojcik J., Legrain P., Gauthier JM Functional Proteomics Mapping of a Human Signaling Pathway // Genome Research : journal. - 2004. - Vol. 14 , no. 7 . - P. 1324-1332 . - DOI : 10.1101 / gr . 2334104 . - PMID 15231748 .
- Kurihara I., Shibata H., Kobayashi S., Suda N., Ikeda Y., Yokota K., Murai A., Saito I., Rainey WE, Saruta T. Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription // Journal of Biological Chemistry : journal. - 2005. - Vol. 280 , no. 8 . - P. 6721–6730 . - DOI : 10.1074 / jbc.M411820200 . - PMID 15611122 .
- Shibata H., Kobayashi S., Kurihara I., Suda N., Yokota K., Murai A., Ikeda Y., Saito I., Rainey WE, Saruta T. COUP-TF and transcriptional co-regulators in adrenal steroidogenesis ( Eng.) // Endocrine Research . - Informa Healthcare 2005. - Vol. 30 , no. 4 . - P. 795-801 . - DOI : 10.1081 / ERC-200044042 . - PMID 15666827 .