RAD9A

This gene product is highly similar to rad9 dividing yeast , a cell cycle checkpoint protein necessary for the cell cycle and repair DNA damage in response to its damage. This protein has been found to have from 3 'to 5' exonuclease activity, which can contribute to its role in detecting and repairing DNA damage. It forms a protein complex checkpoint with RAD1 and HUS1. This complex recruits a reference point of the RAD17 protein to DNA damage sites, which are considered important for triggering a signaling cascade of control points. The use of alternative polyA sites for this gene has been noted. ^[2]

RAD9A has been found to interact with:

• ABL1 , ^[3]
• NR3C4 , ^[4]
• BCL2L1 , ^{[5] [6]}
• BCL2 , ^[6]
• DNAJC7 , ^[7]
• HDAC1 , ^[8]
• HUS1 ^{[9] [10] [11] [12]}
• Homologist RAD1 , ^{[9] [10] [11] [12] [13]}
• RAD17 ^{[9] [13] [14] [15]} and
• TOPBP1 . ^[sixteen]