GLUT5 ( GLUT-5 , glucose transporter type 5 ) is a fructose carrier protein in the apical part of enterocytes of the small intestine [1] . GLUT5 provides the transfer of fructose from the gastrointestinal tract to enterocytes through facilitated diffusion due to the high concentration of fructose in the digestive tract. GLUT5 is also expressed in skeletal muscle [2] , testes , kidneys , adipose tissue ( adipocytes ), and the brain [3] .
| dissolved solids transporters 2 (lightweight glucose / fructose transporters), number 5 | |
|---|---|
| Designations | |
| Characters | SLC2A5 ; GLUT5 |
| Entrez gene | 6518 |
| Hgnc | 11010 |
| Omim | 138230 |
| Refseq | NM_003039 |
| Uniprot | P22732 |
| Other data | |
| Locus | 1st hr. , 1p36.2 |
Fructose malabsorption is a digestive disorder of the small intestine caused by a lack of GLUT5 in enterocytes [4] .
In humans, GLUT5 is encoded by the SLC2A5 gene , which is localized on the 1st chromosome [5] .
Regulation
The absorption rate of fructose by the GLUT5 protein is significantly affected by diabetes mellitus , arterial hypertension , obesity , fructose malabsorption and inflammatory processes . However, age-related changes in the ability to absorb fructose are not explained by the level of GLUT5 expression [6] [7] [8] . The simultaneous presence of glucose improves the absorption of fructose, sorbitol - worsens [9] .
See also
- Membrane proteins
Notes
- ↑ Uldry M., Thorens B. The SLC2 family of facilitated hexose and polyol transporters (Eng.) // Pflügers Archiv: European Journal of Physiology : journal. - 2004 .-- February ( vol. 447 , no. 5 ). - P. 480-489 . - DOI : 10.1007 / s00424-003-1085-0 . - PMID 12750891 .
- ↑ Hundal HS, Darakhshan F., Kristiansen S., Blakemore SJ, Richter EA GLUT5 expression and fructose transport in human skeletal muscle (Eng.) // Advances in Experimental Medicine and Biology : journal. - Springer Nature 1998. - Vol. 441 . - P. 35-45 . - DOI : 10.1007 / 978-1-4899-1928-1_4 . - PMID 9781312 .
- ↑ Douard V., Ferraris RP Regulation of the fructose transporter GLUT5 in health and disease (English) // American Journal of Physiology. Endocrinology and Metabolism : journal. - 2008 .-- August ( vol. 295 , no. 2 ). - P. E227—37 . - DOI : 10.1152 / ajpendo.90245.2008 . - PMID 18398011 .
- ↑ Barone S., Fussell SL, Singh AK, Lucas F., Xu J., Kim C., Wu X., Yu Y., Amlal H., Seidler U., Zuo J., Soleimani M. Slc2a5 (Glut5) Is Essential for the Absorption of Fructose in the Intestine and Generation of Fructose-induced Hypertension (Eng.) // The Journal of Biological Chemistry : journal. - 2009 .-- February ( vol. 284 , no. 8 ). - P. 5056-5066 . - DOI : 10.1074 / jbc.M808128200 . - PMID 19091748 .
- ↑ White PS, Jensen SJ, Rajalingam V., Stairs D., Sulman EP, Maris JM, Biegel JA, Wooster R., Brodeur GM Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36 .2 (eng.) // Cytogenetics and Cell Genetics : journal. - 1998. - Vol. 81 , no. 1 . - P. 60-4 . - DOI : 10.1159 / 000014989 . - PMID 9691177 .
- ↑ Douard V., Ferraris RP Regulation of the fructose transporter GLUT5 in health and disease (Eng.) // Am. J. Physiol. Endocrinol. Metab. : journal. - 2008 .-- August ( vol. 295 , no. 2 ). - P. E227—37 . - DOI : 10.1152 / ajpendo.90245.2008 . - PMID 18398011 .
- ↑ Litherland GJ, Hajduch E., Gould GW, Hundal HS Fructose transport and metabolism in adipose tissue of Zucker rats: diminished GLUT5 activity during obesity and insulin resistance (Eng.) // Mol. Cell. Biochem. : journal. - 2004. - June ( vol. 261 , no. 1-2 ). - P. 23-33 . - PMID 15362482 .
- ↑ Drozdowski LA, Woudstra TD, Wild GE, Clandinin MT, Thomson AB Age-associated changes in intestinal fructose uptake are not explained by alterations in the abundance of GLUT5 or GLUT2 (Eng.) // J. Nutr. Biochem. : journal. - 2004 .-- October ( vol. 15 , no. 10 ). - P. 630-637 . - DOI : 10.1016 / j.jnutbio.2004.06.06.003 . - PMID 15542355 .
- ↑ Heinrich Kasper: Ernährungsmedizin und Diätetik. 11. Auflage, Elsevier, Urban & Fischer-Verlag, 2009, ISBN 9783437420122 , S. 208