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POLR2F

The RPABC2 subunit of DNA-driven RNA polymerase I, II and III is a protein encoded in humans by the POLR2F gene . [one]

Polypeptide F of RNA polymerase II (DNA controlled)
Protein POLR2F PDB 1qkl.png
PDB rendering based on 1qkl.
Available structures
PDBSearch for orthologs: PDBe , RCSB
PDB ID List
Identifiers
Symbol; HRBP14.4; POLRF; RPABC14.4; RPABC2; RPB14.4; RPB6; RPC15
External idGeneCards :
EC number
Gene ontology
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Sources: Amigo / QuickGO
RNA expression profile
PBB GE POLR2F 209511 at tn.png
Ortologists
ViewPersonMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Locus (UCSC)
PubMed Search

This gene encodes the sixth largest subunit of RNA polymerase II , the polymerase responsible for the synthesis of RNA messenger in eukaryotes , in which two other DNA-controlled RNA polymerases are also involved. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes polymerase transcription in the DNA template. [2]

Interactions

POLR2F, as has been identified, interacts with POLR2C . [3]

Notes

  1. ↑ Pusch C., Wang Z., Roe B., Blin N. Genomic structure of the polymerase II small subunit (hRPB14.4) locus (POLRF) and mapping to 22q13.1 by sequence identity (Engl.) // Genomics : journal. - Academic Press , 1996. - September ( vol. 34 , no. 3 ). P. 440-442 . - DOI : 10.1006 / geno.1996.0312 . - PMID 8786150 .
  2. Rez Entrez Gene: POLR2F polymerase (RNA) II (DNA directed) polypeptide F (Neop.) .
  3. ↑ Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M. Interactions between the human RNA polymerase II subunits (Eng.) // J. Biol. Chem. : journal. - UNITED STATES, 1997. - July ( vol. 272 , no. 27 ). - P. 16815-16821 . - ISSN 0021-9258 . - DOI : 10.1074 / jbc.272.27.16815 . - PMID 9201987 .

Literature

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  • Yankulov K., Bentley D. Transcriptional control: Tat cofactors and transcriptional elongation. (English) // Curr. Biol. : journal. - 1998. - Vol. 8 , no. 13 - P. R447-9 . - DOI : 10.1016 / S0960-9822 (98) 70289-1 . - PMID 9651670 .
  • Romano G; Kasten M; De Falco G; Micheli, Pietro; Khalili, Kamel; Giordano, Antonio. Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression (Eng.) // J. Cell. Biochem. : journal. - 2000. - Vol. 75 , no. 3 - P. 357-368 . - DOI : 10.1002 / (SICI) 1097-4644 (19991201) 75: 3 <357 :: AID-JCB1> 3.0.CO; 2-K . - PMID 10536359 .
  • Marcello A., Zoppé M., Giacca M. Multiple modes of transcriptional regulation of HIV-1 Tat transactivator (Eng.) // IUBMB Life: journal. - 2002. - Vol. 51 , no. 3 - P. 175-181 . - DOI : 10.1080 / 152165401753544241 . - PMID 11547919 .
  • Stevens, M., De Clercq, E., Balzarini, J. The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention (Eng.) // Med Res Rev: journal. - 2007. - Vol. 26 , no. 5 - P. 595-625 . - DOI : 10.1002 / med.20081 . - PMID 16838299 .
  • Harrich D; McMillan N; Munoz L; Apolloni, Ann; Meredith, Luke. Will diverse tat interactions lead to novel antiretroviral drug targets? (eng.) // Current drug targets: journal. - 2007. - Vol. 7 , no. 12 - P. 1595-1606 . - DOI : 10.2174 / 138945006779025338 . - PMID 17168834 .
  • Kato H; Sumimoto H; Pognonec P; Chen, CH; Rosen, CA; Roeder, R G. HIV-1 Tatons as a processivity factor in vitro in conjunction with cellular elongation factors (Engl.) // Genes Dev. : journal. - 1992. - Vol. 6 , no. 4 - P. 655-666 . - DOI : 10.1101 / gad.6.4.655 . - PMID 1559613 .
  • Southgate C., Zapp ML, Green MR. Activation of transcription by HIV-1. Tat protein tethered to nascent RNA // Nature: journal. - 1990. - Vol. 345 , no. 6276 . - P. 640-642 . - DOI : 10.1038 / 345640a0 . - PMID 2190099 .
  • Wu-Baer F., Sigman D., Gaynor RB Specific Binding of RNA Polymerase II Transforming the RNA is not defined as Protoedings of the National Academy of Sciences. United States of America : journal. - 1995. - Vol. 92 , no. 16 - P. 7153-7157 . - DOI : 10.1073 / pnas.92.16.7153 . - PMID 7638159 .
  • Acker J., Wintzerith M., Vigneron M., Kedinger C. A 14.4 RNA polymerase II with a putative leucine-zipper (Eng.) // DNA Seq. : journal. - 1995. - Vol. 4 , no. 5 - P. 329-331 . - DOI : 10.3109 / 10425179409020860 . - PMID 7803819 .
  • Herrmann CH, Rice AP, Lentavirus Tat, Protein Protein, RNA polymerase II: Candidate for a Tat cofactor (Eng.) // J. Virol. : journal. - 1995. - Vol. 69 , no. 3 - P. 1612-1620 . - PMID 7853496 .
  • Keen NJ, Gait MJ, Karn J. Human Transformance Complex transcription-elongation complex ( TYL ) // Proceedings of the United States of America : journal. - 1996. - Vol. 93 , no. 6 - P. 2505-2510 . - DOI : 10.1073 / pnas.93.6.2505 . - PMID 8637904 .
  • Yang X., Herrmann CH, Rice AP, RNA polymerase II for function (English) // J. Virol. : journal. - 1996. - Vol. 70 , no. 7 P. 4576–4584 . - PMID 8676484 .
  • Agostini I; Navarro JM; Rey F; Bouhamdan, M; Spire, B; Vigne, R; Sire, J. The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB (English) // J. Mol. Biol. : journal. - 1996. - Vol. 261 , no. 5 - P. 599-606 . - DOI : 10.1006 / jmbi.1996.0485 . - PMID 8800208 .
  • Zhou Q., Sharp PA Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat (eng.) // Science: journal. - 1996. - Vol. 274 , no. 5287 . - P. 605-610 . - DOI : 10.1126 / science.274.5287.605 . - PMID 8849451 .
  • Okamoto H; Sheline CT; Corden JL; Jones, KA; Peterlin, BM Trans-activation by a human immunodeficiency virus for RNA polymerase II (Eng.) // Proceedings of the United States of America : journal. - 1996. - Vol. 93 , no. 21 . - P. 11575-11579 . - DOI : 10.1073 / pnas.93.21.11575 . - PMID 8876177 .
  • Chun RF, Jeang KT Requirements for T-cell lymphotropic virus I and HIV-1 (English) // J. Biol. Chem. : journal. - 1996. - Vol. 271 , no. 44 . - P. 27888-27894 . - DOI : 10.1074 / jbc.271.44.27888 . - PMID 8910388 .
  • Parada CA, Roeder RG Enhanced processna of polymerase II triggered by RNA by Tat-induced phosphorylation of the carboxy-terminal domain (Eng.) // Nature: journal. - 1996. - Vol. 384 , no. 6607 . - P. 375-378 . - DOI : 10.1038 / 384375a0 . - PMID 8934526 .
  • García-Martínez LF, Ivanov D., Gaynor and transcription preinitiation (English) // J. Biol. Chem. : journal. - 1997. - Vol. 272 , no. 11 - P. 6951-6958 . - DOI : 10.1074 / jbc.272.11.6951 . - PMID 9054383 .
Source - https://ru.wikipedia.org/w/index.php?title=POLR2F&oldid=101280156


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