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Histone deacetylase 1

Histone deacetylase 1 is an enzyme that is encoded by the HDAC1 gene in humans. [one]

Histone deacetylase 1
Available Structures
PDBOrtholog Search: PDBe , RCSB
PDB ID List
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Identifiers
Symbol; GON-10; HD1; RPD3; RPD3L1
External IDsChEMBL : GeneCards :
EC number
Gene ontology
Functionβ€’

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Sources: Amigo / QuickGO
RNA expression profile
PBB GE HDAC1 201209 at tn.png
Orthologists
ViewPersonMouse
Entrez
Ensembl
Uniprot
RefSeq (mRNA)
RefSeq (protein)
Locus (UCSC)
Search PubMed

Function

It carries out acetylation and deacetylation of histones, catalysis of multisubunit complexes, and plays a key role in the regulation of eukaryotic gene expression . The protein encoded by this gene belongs to the histone deacetylase / acuc / apha family and is an integral part of the histone deacetylase complex. It also interacts with a retinoblastoma tumor suppressor protein, and this complex is a key element in the management of cell proliferation and differentiation. Together with the metastasized protein-2 MTA2 , deacetylates p53 and modulates its effect on cell growth and apoptosis . [2]

Model organisms

Hdac1 phenotype knockout mouse
SpecificationsPhenotype
Homosites viabilityAbnormal
Recessive lethal studyabnormal
FertilityNorm
Body weightNorm
AnxietyNorm
Neurological examinationNorm
Grab powerNorm
Hot plateNorm
DysmorphologyNorm
Indirect calorimetryNorm
Glucose tolerance testNorm
Auditory brainstem responseNorm
DexaNorm
RoentgenographyNorm
Body temperatureNorm
Eye morphologyNorm
Clinical chemistryNorm
HematologyNorm
Peripheral LymphocytesNorm
Micronucleus testNorm
Heart massNorm
Histopathology of the brainNorm
Histopathology of the eyesNorm
SalmonellaNormal [3]
Citrobacter infectionNormal [4]
All tests and analyzes from [5] [6]

Model organisms were used to study the function of HDAC1. A conditional line of knockout mice called Hdac1 tm1a (EUCOMM) Wtsi [7] [8] was created as part of the international knockout mouse consortium program, a high-throughput mutagenesis project for the creation and distribution of animal models for the study of diseases by interested scientists at the Senger Institute . [9] [10] [11] Male and female individuals underwent a standard phenotypic examination to determine the effects of removal. [5] [12] Twenty-five trials were conducted and two phenotypes were found to be abnormal. A reduction in the number of homozygous mutants was detected in embryos during pregnancy, and no one survived until the end of lactation. The remaining tests were carried out on heterozygous mutants of adult mice, and no significant deviations were found in these animals. [five]

Interactions

HDAC 1 has been found to interact with:

  • Androgen receptor , [13]
  • BCL6 , [14] [15]
  • BTG2 , [16]
  • BUB1B , [17]
  • BUB1 , [17]
  • BUB3 , [17]
  • CBFA2T3 , [18] [19]
  • CDC20 , [17]
  • CDH1 , [17]
  • CHD3 , [20] [21]
  • CHD4 , [22] [20] [23]
  • COUP-TFII , [24]
  • CTBP1 , [25] [26] [27]
  • DDX17 , [28]
  • DDX5 , [28]
  • DNMT3A , [29]
  • DNMT3L , [30] [31]
  • Death-associated protein 6 , [32]
  • EED , [33]
  • EVI1 , [34] [35]
  • EZH2 , [33]
  • FKBP3 , [36]
  • GATA1 , [37]
  • HMG20B , [38]
  • HSPA4 , [39]
  • HUS1 , [40]
  • Histone deacetylase 2 , [22] [41] [38] [42] [43] [39] [44] [45] [46] [20] [47] [48] [33]
  • TGIF1 , [25] [49]
  • HCFC1 , [50]
  • IFRD1 , [51]
  • IKZF1 , [52] [53]
  • ING1 , [21] [54]
  • MBD3 , [46] [55] [56]
  • MIER1 , [57]
  • MLL , [58]
  • MTA1 , [22] [59]
  • MTA2 , [22] [46] [60] [61]
  • Mad1 , [17]
  • Mdm2 , [62]
  • MBD2 , [46] [63] [64]
  • SMAD2 , [65]
  • MyoD , [66] [67]
  • NFKB1 , [68]
  • NCOR2 , [41] [69]
  • PCNA , [70]
  • PHF21A , [38] [71]
  • Prohibitin , [72] [73]
  • Protein of Promyelocytic Leukemia , [74] [75]
  • RAD9A , [40]
  • RBBP4 , [22] [46] [47] [48] [76] [23] [60] [77] [63] [78] [79]
  • RBBP7 , [22] [46] [48] [63]
  • RCOR1 , [38] [60]
  • RELA , [45] [80] [68]
  • RFC1 , [81]
  • Retinoblastoma protein , [73] [66] [82] [83] [84] [85] [86]
  • RBL1 , [82] [83]
  • RBL2 , [82] [87]
  • SAP30 , [46] [21] [88] [89] [90] [91]
  • SATB1 , [61]
  • SIN3A , [22] [46] [20] [47] [76] [92] [93] [23] [94] [60] [77] [61] [95] [21]
  • SIN3B , [52] [46]
  • SPEN , [96]
  • SUDS3 , [92] [97]
  • SUV39H1 , [98]
  • Sp1 , [77] [99] [100] [101]
  • TOP2A , [102] [103]
  • TOP2B , [102] [103] and
  • Zinc finger and BTB domain containing protein 16 . [104] [14] [105]

Notes

  1. ↑ Taunton J., Hassig CA, Schreiber SL A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p (Eng.) // Science: journal. - 1996 .-- May ( vol. 272 , no. 5260 ). - P. 408-411 . - DOI : 10.1126 / science.272.5260.408 . - PMID 8602529 .
  2. ↑ Entrez Gene: HDAC1 histone deacetylase 1 (neopr.) .
  3. ↑ Salmonella infection data for Hdac1 (neopr.) . Wellcome Trust Sanger Institute.
  4. ↑ Citrobacter infection data for Hdac1 (neopr.) . Wellcome Trust Sanger Institute.
  5. ↑ 1 2 3 Gerdin AK The Sanger Mouse Genetics Program: High throughput characterization of knockout mice (Eng.) // Acta Ophthalmologica : journal. - Wiley-Liss , 2010 .-- Vol. 88 , no. S248 . - DOI : 10.1111 / j.1755-3768.2010.4142.x .
  6. ↑ Mouse Resources Portal , Wellcome Trust Sanger Institute.
  7. ↑ International Knockout Mouse Consortium (Neopr.) .
  8. ↑ Mouse Genome Informatics (neopr.) .
  9. ↑ Skarnes WC, Rosen B., West AP, Koutsourakis M., Bushell W., Iyer V., Mujica AO, Thomas M., Harrow J., Cox T., Jackson D., Severin J., Biggs P., Fu J., Nefedov M., de Jong PJ, Stewart AF, Bradley A. A conditional knockout resource for the genome-wide study of mouse gene function (Eng.) // Nature: journal. - 2011. - Vol. 474 , no. 7351 . - P. 337β€”342 . - DOI : 10.1038 / nature10163 . - PMID 21677750 .
  10. ↑ Dolgin E. Mouse library set to be knockout (Eng.) // Nature. - 2011 .-- June ( vol. 474 , no. 7351 ). - P. 262-263 . - DOI : 10.1038 / 474262a . - PMID 21677718 .
  11. ↑ Collins FS, Rossant J., Wurst W. A mouse for all reasons (English) // Cell . - Cell Press 2007 .-- January ( vol. 128 , no. 1 ). - P. 9-13 . - DOI : 10.1016 / j.cell.2006.12.018 . - PMID 17218247 .
  12. ↑ van der Weyden L., White JK, Adams DJ, Logan DW The mouse genetics toolkit: revealing function and mechanism. (Eng.) // Genome Biol : journal. - 2011. - Vol. 12 , no. 6 . - P. 224 . - DOI : 10.1186 / gb-2011-12-6-224 . - PMID 21722353 .
  13. ↑ Gaughan L., Logan IR, Cook S., Neal DE, Robson CN Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor (Eng.) // J. Biol. Chem. : journal. - 2002 .-- July ( vol. 277 , no. 29 ). - P. 25904-25913 . - DOI : 10.1074 / jbc.M203423200 . - PMID 11994312 .
  14. ↑ 1 2 David G., Alland L., Hong SH, Wong CW, DePinho RA, Dejean A. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein (Eng.) // Oncogene : journal. - 1998 .-- May ( vol. 16 , no. 19 ). - P. 2549-2556 . - DOI : 10.1038 / sj.onc . 1202043 . - PMID 9627120 .
  15. ↑ Deltour S., Guerardel C., Leprince D. Recruitment of SMRT / N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB / POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B .) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 1999 .-- December ( vol. 96 , no. 26 ). - P. 14831-14836 . - DOI : 10.1073 / pnas.96.26.14831 . - PMID 10611298 .
  16. ↑ Farioli-Vecchioli S., Tanori M., Micheli L., Mancuso M., Leonardi L., Saran A., Ciotti MT, Ferretti E., Gulino A., Pazzaglia S., Tirone F. Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3 (eng.) // The FASEB Journal : journal. - Federation of American Societies for Experimental Biology 2007 .-- July ( vol. 21 , no. 9 ). - P. 2215-2225 . - DOI : 10.1096 / fj.06-7548com . - PMID 17371797 .
  17. ↑ 1 2 3 4 5 6 Yoon YM, Baek KH, Jeong SJ, Shin HJ, Ha GH, Jeon AH, Hwang SG, Chun JS, Lee CW WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase // FEBS Lett. : journal. - 2004 .-- September ( vol. 575 , no. 1-3 ). - P. 23-9 . - DOI : 10.1016 / j.febslet.2004.07.0.089 . - PMID 15388328 .
  18. ↑ Hoogeveen AT, Rossetti S., Stoyanova V., Schonkeren J., Fenaroli A., Schiaffonati L., van Unen L., Sacchi N. The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21) -positive myeloid malignancies (English) // Oncogene : journal. - 2002 .-- September ( vol. 21 , no. 43 ). - P. 6703-6712 . - DOI : 10.1038 / sj.onc . 1205882 . - PMID 12242670 .
  19. ↑ Amann JM, Nip J., Strom DK, Lutterbach B., Harada H., Lenny N., Downing JR, Meyers S., Hiebert SW ETO, a target of t (8; 21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain (Eng.) // Mol. Cell. Biol. : journal. - 2001 .-- October ( vol. 21 , no. 19 ). - P. 6470-6483 . - DOI : 10.1128 / mcb.21.19.6470-6483.2001 . - PMID 11533236 .
  20. ↑ 1 2 3 4 Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL Chromatin deacetylation by an ATP-dependent nucleosome remodeling complex (Eng.) // Nature: journal. - 1998 .-- October ( vol. 395 , no. 6705 ). - P. 917-921 . - DOI : 10.1038 / 27699 . - PMID 9804427 .
  21. ↑ 1 2 3 4 Kuzmichev A., Zhang Y., Erdjument-Bromage H., Tempst P., Reinberg D. Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33 (ING1 ) // Mol. Cell. Biol. : journal. - 2002 .-- February ( vol. 22 , no. 3 ). - P. 835-848 . - DOI : 10.1128 / mcb.22.3.835-848.2002 . - PMID 11784859 .
  22. ↑ 1 2 3 4 5 6 7 Yao YL, Yang WM The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity (Eng.) // J. Biol. Chem. : journal. - 2003 .-- October ( vol. 278 , no. 43 ). - P. 42560-42568 . - DOI : 10.1074 / jbc.M302955200 . - PMID 12920132 .
  23. ↑ 1 2 3 Grozinger CM, Hassig CA, Schreiber SL Three proteins define a class of human histone deacetylases related to yeast Hda1p // Proceedings of the National Academy of Sciences of the United States of America : journal. - 1999 .-- April ( vol. 96 , no. 9 ). - P. 4868-4873 . - DOI : 10.1073 / pnas.96.9.4868 . - PMID 10220385 .
  24. ↑ Smirnov DA, Hou S., Ricciardi RP Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription (Eng.) // Virology: journal. - 2000 .-- March ( vol. 268 , no. 2 ). - P. 319β€”328 . - DOI : 10.1006 / viro.1999.0181 . - PMID 10704340 .
  25. ↑ 1 2 Melhuish TA, Wotton D. The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF // J. Biol. Chem. : journal. - 2000 .-- December ( vol. 275 , no. 50 ). - P. 39762-39766 . - DOI : 10.1074 / jbc.C000416200 . - PMID 10995736 .
  26. ↑ Zhang CL, McKinsey TA, Lu JR, Olson EN Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor (Eng.) // J. Biol . Chem. : journal. - 2001 .-- January ( vol. 276 , no. 1 ). - P. 35-9 . - DOI : 10.1074 / jbc.M007364200 . - PMID 11022042 .
  27. ↑ Sundqvist A., Sollerbrant K., Svensson C. The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex (Eng.) // FEBS Lett. : journal. - 1998 .-- June ( vol. 429 , no. 2 ). - P. 183-188 . - DOI : 10.1016 / s0014-5793 (98) 00588-2 . - PMID 9650586 .
  28. ↑ 1 2 Wilson BJ, Bates GJ, Nicol SM, Gregory DJ, Perkins ND, Fuller-Pace FV The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner (Eng.) // BMC Mol . Biol. : journal. - 2004 .-- August ( vol. 5 ). - P. 11 . - DOI : 10.1186 / 1471-2199-5-11 . - PMID 15298701 .
  29. ↑ Fuks F., Burgers WA, Godin N., Kasai M., Kouzarides T. Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription (English) // EMBO J. : journal. - 2001 .-- May ( vol. 20 , no. 10 ). - P. 2536-2544 . - DOI : 10.1093 / emboj / 20.10.2536 . - PMID 11350943 .
  30. ↑ Aapola U., Liiv I., Peterson P. Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity (Eng.) // Nucleic Acids Res. : journal. - 2002 .-- August ( vol. 30 , no. 16 ). - P. 3602-3608 . - DOI : 10.1093 / nar / gkf474 . - PMID 12177302 .
  31. ↑ Deplus R., Brenner C., Burgers WA, Putmans P., Kouzarides T., de Launoit Y., Fuks F. Dnmt3L is a transcriptional repressor that recruits histone deacetylase (Eng.) // Nucleic Acids Res. : journal. - 2002 .-- September ( vol. 30 , no. 17 ). - P. 3831-3838 . - DOI : 10.1093 / nar / gkf509 . - PMID 12202768 .
  32. ↑ Li H., Leo C., Zhu J., Wu X., O'Neil J., Park EJ, Chen JD Sequestration and inhibition of Daxx-mediated transcriptional repression by PML (Eng.) // Mol. Cell. Biol. : journal. - 2000 .-- March ( vol. 20 , no. 5 ). - P. 1784-1796 . - DOI : 10.1128 / mcb.20.5.1784-1796.2000 . - PMID 10669754 .
  33. ↑ 1 2 3 van der Vlag J., Otte AP Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation (Eng.) // Nat. Genet. : journal. - 1999 .-- December ( vol. 23 , no. 4 ). - P. 474β€”478 . - DOI : 10.1038 / 70602 . - PMID 10581039 .
  34. ↑ Vinatzer U., Taplick J., Seiser C., Fonatsch C., Wieser R. The leukaemia-associated transcription factors EVI-1 and MDS1 / EVI1 repress transcription and interact with histone deacetylase (Eng.) // Br. J. Haematol. : journal. - 2001 .-- September ( vol. 114 , no. 3 ). - P. 566-573 . - DOI : 10.1046 / j.1365-2141.2001.02987.x . - PMID 11552981 .
  35. ↑ Chakraborty S., Senyuk V., Sitailo S., Chi Y., Nucifora G. Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300 / CBP-associated factor (P / CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles (Eng.) // J. Biol. Chem. : journal. - 2001 .-- November ( vol. 276 , no. 48 ). - P. 44936-44943 . - DOI : 10.1074 / jbc.M106733200 . - PMID 11568182 .
  36. ↑ Yang WM, Yao YL, Seto E. The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1 (English) // EMBO J. : journal. - 2001 .-- September ( vol. 20 , no. 17 ). - P. 4814-4825 . - DOI : 10.1093 / emboj / 20.17.4814 . - PMID 11532945 .
  37. ↑ Watamoto K., Towatari M., Ozawa Y., Miyata Y., Okamoto M., Abe A., Naoe T., Saito H. Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation (Eng.) // Oncogene : journal. - 2003 .-- December ( vol. 22 , no. 57 ). - P. 9176-9184 . - DOI : 10.1038 / sj.onc . 1206902 . - PMID 14668799 .
  38. ↑ 1 2 3 4 Hakimi MA, Bochar DA, Chenoweth J., Lane WS, Mandel G., Shiekhattar R. A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes (English) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 2002 .-- May ( vol. 99 , no. 11 ). - P. 7420-7425 . - DOI : 10.1073 / pnas.112008599 . - PMID 12032298 .
  39. ↑ 1 2 Johnson CA, White DA, Lavender JS, O'Neill LP, Turner BM Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70 // J. Biol. Chem. : journal. - 2002 .-- March ( vol. 277 , no. 11 ). - P. 9590-9597 . - DOI : 10.1074 / jbc.M107942200 . - PMID 11777905 .
  40. ↑ 1 2 Cai RL, Yan-Neale Y., Cueto MA, Xu H., Cohen D. HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2 / M checkpoint Rad proteins (Eng.) // J . Biol. Chem. : journal. - 2000 .-- September ( vol. 275 , no. 36 ). - P. 27909β€”27916 . - DOI : 10.1074 / jbc.M000168200 . - PMID 10846170 .
  41. ↑ 1 2 Fischer DD, Cai R., Bhatia U., Asselbergs FA, Song C., Terry R., Trogani N., Widmer R., Atadja P., Cohen D. Isolation and characterization of a novel class II histone deacetylase , HDAC10 (Eng.) // J. Biol. Chem. : journal. - 2002 .-- February ( vol. 277 , no. 8 ). - P. 6656–6666 . - DOI : 10.1074 / jbc.M108055200 . - PMID 11739383 .
  42. ↑ Hakimi MA, Dong Y., Lane WS, Speicher DW, Shiekhattar R. A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes (Eng.) // J. Biol. Chem. : journal. - 2003 .-- February ( vol. 278 , no. 9 ). - P. 7234-7239 . - DOI : 10.1074 / jbc.M208992200 . - PMID 12493763 .
  43. ↑ Fischle W., Dequiedt F., Hendzel MJ, Guenther MG, Lazar MA, Voelter W., Verdin E. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT / N-CoR // Mol. Cell : journal. - 2002 .-- January ( vol. 9 , no. 1 ). - P. 45-57 . - DOI : 10.1016 / s1097-2765 (01) 00429-4 . - PMID 11804585 .
  44. ↑ Fischle W., Dequiedt F., Fillion M., Hendzel MJ, Voelter W., Verdin E. Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo // J. Biol. Chem. : journal. - 2001 .-- September ( vol. 276 , no. 38 ). - P. 35826-35835 . - DOI : 10.1074 / jbc.M104935200 . - PMID 11466315 .
  45. ↑ 1 2 Ashburner BP, Westerheide SD, Baldwin AS The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression (Eng.) // Mol. Cell. Biol. : journal. - 2001 .-- October ( vol. 21 , no. 20 ). - P. 7065-7077 . - DOI : 10.1128 / MCB.21.20.7065-7077.2001 . - PMID 11564889 .
  46. ↑ 1 2 3 4 5 6 7 8 9 Zhang Y., Ng HH, Erdjument-Bromage H., Tempst P., Bird A., Reinberg D. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation (Eng.) // Genes Dev. : journal. - 1999 .-- August ( vol. 13 , no. 15 ). - P. 1924-1935 . - DOI : 10.1101 / gad.13.15.1924 . - PMID 10444591 .
  47. ↑ 1 2 3 Hassig CA, Tong JK, Fleischer TC, Owa T., Grable PG, Ayer DE, Schreiber SL A role for histone deacetylase activity in HDAC1-mediated transcriptional repression (Eng.) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 1998 .-- March ( vol. 95 , no. 7 ). - P. 3519-3524 . - DOI : 10.1073 / pnas.95.7.3519 . - PMID 9520398 .
  48. ↑ 1 2 3 Zhang Y., Iratni R., Erdjument-Bromage H., Tempst P., Reinberg D. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex (Eng.) // Cell : journal . - Cell Press 1997. - May ( vol. 89 , no. 3 ). - P. 357-364 . - DOI : 10.1016 / s0092-8674 (00) 80216-0 . - PMID 9150135 .
  49. ↑ Melhuish TA, Gallo CM, Wotton D. TGIF2 interacts with histone deacetylase 1 and represses transcription (Eng.) // J. Biol. Chem. : journal. - 2001 .-- August ( vol. 276 , no. 34 ). - P. 32109β€”32114 . - DOI : 10.1074 / jbc.M103377200 . - PMID 11427533 .
  50. ↑ Wysocka J., Myers MP, Laherty CD, Eisenman RN, Herr W. Human Sin3 deacetylase and trithorax-related Set1 / Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 (Eng.) / / Genes Dev. : journal. - 2003 .-- April ( vol. 17 , no. 7 ). - P. 896-911 . - DOI : 10.1101 / gad.252103 . - PMID 12670868 .
  51. ↑ Vietor I., Vadivelu SK, Wick N., Hoffman R., Cotten M., Seiser C., Fialka I., Wunderlich W., Haase A., Korinkova G., Brosch G., Huber LA TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells (English) // EMBO J. : journal. - 2002 .-- September ( vol. 21 , no. 17 ). - P. 4621–4631 . - DOI : 10.1093 / emboj / cdf461 . - PMID 12198164 .
  52. ↑ 1 2 Koipally J., Renold A., Kim J., Georgopoulos K. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes (Eng.) // EMBO J. : journal. - 1999 .-- June ( vol. 18 , no. 11 ). - P. 3090-3100 . - DOI : 10.1093 / emboj / 11.18.3090 . - PMID 10357820 .
  53. ↑ Koipally J., Georgopoulos K. A molecular dissection of the repression circuitry of Ikaros (Eng.) // J. Biol. Chem. : journal. - 2002 .-- August ( vol. 277 , no. 31 ). - P. 27697-27705 . - DOI : 10.1074 / jbc.M201694200 . - PMID 12015313 .
  54. ↑ Vieyra D., Loewith R., Scott M., Bonnefin P., Boisvert FM, Cheema P., Pastyryeva S., Meijer M., Johnston RN, Bazett-Jones DP, McMahon S., Cole MD, Young D. , Riabowol K. Human ING1 proteins differentially regulate histone acetylation (Eng.) // J. Biol. Chem. : journal. - 2002 .-- August ( vol. 277 , no. 33 ). - P. 29832-29838 . - DOI : 10.1074 / jbc.M200197200 . - PMID 12015309 .
  55. ↑ Sakai H., Urano T., Ookata K., Kim MH, Hirai Y., Saito M., Nojima Y., Ishikawa F. MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M ​​phase (English) // J. Biol. Chem. : journal. - 2002 .-- December ( vol. 277 , no. 50 ). - P. 48714-48723 . - DOI : 10.1074 / jbc.M208461200 . - PMID 12354758 .
  56. ↑ Saito M., Ishikawa F. The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD / Mi2 components HDAC1 and MTA2 // J. Biol. Chem. : journal. - 2002 .-- September ( vol. 277 , no. 38 ). - P. 35434-35439 . - DOI : 10.1074 / jbc.M203455200 . - PMID 12124384 .
  57. ↑ Ding Z., Gillespie LL, Paterno GD Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain (Eng.) // Mol. Cell. Biol. : journal. - 2003 .-- January ( vol. 23 , no. 1 ). - P. 250β€”258 . - DOI : 10.1128 / mcb.23.1.250-258.2003 . - PMID 12482978 .
  58. ↑ Xia ZB, Anderson M., Diaz MO, Zeleznik-Le NJ MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein (English) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 2003 .-- July ( vol. 100 , no. 14 ). - P. 8342-8347 . - DOI : 10.1073 / pnas.1436338100 . - PMID 12829790 .
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  78. ↑ Nicolas E., Ait-Si-Ali S., Trouche D. The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein (Eng.) // Nucleic Acids Res. : journal. - 2001 .-- August ( vol. 29 , no. 15 ). - P. 3131-3136 . - DOI : 10.1093 / nar / 29.15.3131 . - PMID 11470869 .
  79. ↑ Hassig CA, Fleischer TC, Billin AN, Schreiber SL, Ayer DE Histone deacetylase activity is required for full transcriptional repression by mSin3A (English) // Cell : journal. - Cell Press 1997. - May ( vol. 89 , no. 3 ). - P. 341β€”347 . - DOI : 10.1016 / s0092-8674 (00) 80214-7 . - PMID 9150133 .
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  81. ↑ Anderson LA, Perkins ND The large subunit of replication factor C interacts with the histone deacetylase, HDAC1 (Eng.) // J. Biol. Chem. : journal. - 2002 .-- August ( vol. 277 , no. 33 ). - P. 29550-29554 . - DOI : 10.1074 / jbc.M200513200 . - PMID 12045192 .
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  91. ↑ Yochum GS, Ayer DE Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex (Eng.) // Mol. Cell. Biol. : journal. - 2001 .-- July ( vol. 21 , no. 13 ). - P. 4110-4118 . - DOI : 10.1128 / MCB.21.13.4110-4118.2001 . - PMID 11390640 .
  92. ↑ 1 2 Fleischer TC, Yun UJ, Ayer DE Identification and characterization of three new components of the mSin3A corepressor complex (Eng.) // Mol. Cell. Biol. : journal. - 2003 .-- May ( vol. 23 , no. 10 ). - P. 3456-3467 . - DOI : 10.1128 / mcb.23.10.3456-3467.2003 . - PMID 12724404 .
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  94. ↑ Zhang J., Kalkum M., Chait BT, Roeder RG The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 (Eng.) // Mol. Cell : journal. - 2002 .-- March ( vol. 9 , no. 3 ). - P. 611-623 . - DOI : 10.1016 / s1097-2765 (02) 00468-9 . - PMID 11931768 .
  95. ↑ Huang EY, Zhang J., Miska EA, Guenther MG, Kouzarides T., Lazar MA Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway (Eng.) // Genes Dev. : journal. - 2000 .-- January ( vol. 14 , no. 1 ). - P. 45-54 . - PMID 10640275 .
  96. ↑ Shi Y., Downes M., Xie W., Kao HY, Ordentlich P., Tsai CC, Hon M., Evans RM Sharp, an inducible cofactor that integrates nuclear receptor repression and activation (Eng.) // Genes Dev. : journal. - 2001 .-- May ( vol. 15 , no. 9 ). - P. 1140-1151 . - DOI : 10.1101 / gad . 871201 . - PMID 11331609 .
  97. ↑ Alland L., David G., Shen-Li H., Potes J., Muhle R., Lee HC, Hou H., Chen K., DePinho RA Identification of mammalian Sds3 as an integral component of the Sin3 / histone deacetylase corepressor complex (Eng.) // Mol. Cell. Biol. : journal. - 2002 .-- April ( vol. 22 , no. 8 ). - P. 2743-2750 . - DOI : 10.1128 / mcb.22.8.2743-2750.2002 . - PMID 11909966 .
  98. ↑ Vaute O., Nicolas E., Vandel L., Trouche D. Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases (Eng.) // Nucleic Acids Res. : journal. - 2002 .-- January ( vol. 30 , no. 2 ). - P. 475-481 . - DOI : 10.1093 / nar / 30.2.475 . - PMID 11788710 .
  99. ↑ Di Padova M., Bruno T., De Nicola F., Iezzi S., D'Angelo C., Gallo R., Nicosia D., Corbi N., Biroccio A., Floridi A., Passananti C., Fanciulli M. Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1 / CIP1 promoter (Eng.) // J. Biol. Chem. : journal. - 2003 .-- September ( vol. 278 , no. 38 ). - P. 36496-36504 . - DOI : 10.1074 / jbc.M306694200 . - PMID 12847090 .
  100. ↑ Singh J., Murata K., Itahana Y., Desprez PY Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1 / Rb / HDAC-1 transcription repressor complex ) // Oncogene : journal. - 2002 .-- March ( vol. 21 , no. 12 ). - P. 1812-1822 . - DOI : 10.1038 / sj.onc . 1205252 . - PMID 11896613 .
  101. ↑ Sun JM, Chen HY, Moniwa M., Litchfield DW, Seto E., Davie JR The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2 (Eng.) // J. Biol. Chem. : journal. - 2002 .-- September ( vol. 277 , no. 39 ). - P. 35783β€”35786 . - DOI : 10.1074 / jbc.C200378200 . - PMID 12176973 .
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  103. ↑ 1 2 Johnson CA, Padget K., Austin CA, Turner BM Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis (Eng.) // J. Biol. Chem. : journal. - 2001 .-- February ( vol. 276 , no. 7 ). - P. 4539–4542 . - DOI : 10.1074 / jbc.C000824200 . - PMID 11136718 .
  104. ↑ Chauchereau A., Mathieu M., de Saintignon J., Ferreira R., Pritchard LL, Mishal Z., Dejean A., Harel-Bellan A. HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF (eng. ) // Oncogene : journal. - 2004 .-- November ( vol. 23 , no. 54 ). - P. 8777-8784 . - DOI : 10.1038 / sj.onc . 1208128 . - PMID 15467736 .
  105. ↑ Wong CW, Privalsky ML Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6 (Eng.) // J. Biol. Chem. : journal. - 1998 .-- October ( vol. 273 , no. 42 ). - P. 27695-27702 . - DOI : 10.1074 / jbc.273.42.27695 . - PMID 9765306 .

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Source - https://ru.wikipedia.org/w/index.php?title= Histone deacetylase_1&oldid = 100886295


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