NAN-190 is a medicine and research substance widely used in scientific research. NAN-190 was previously thought to be a selective antagonist of 5-HT 1A receptors , but later it was shown that NAN-190 also strongly blocks α 2 -adrenoreceptors [1] This raises questions about the correctness of the results of studies using NAN-190 as a specific serotonin receptor antagonist. [one]
| NAN-190 | |
|---|---|
 | |
| Chemical compound | |
| IUPAC | 1- (2-Methoxyphenyl) -4- (4-phthalimidobutyl) piperazine |
| Gross formula | C 23 H 27 N 3 O 3 |
| Molar mass | 393.478 g / mol |
| Cas | |
| PubChem | |
Notes
- ↑ 1 2 Foong JP, Bornstein JC. 5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig. (English) // Neuroreport. : journal. - 2009. - Vol. 20 , no. 3 . - P. 325-330 . - DOI : 10.1097 / WNR.0b013e3283232caa . - PMID 19190523 .