Isamoltan ( CGP-361A ) is a substance used in scientific research. It acts as an antagonist of β-adrenergic receptors , 5-HT 1A receptors , as well as 5-HT 1B receptors . It has about 5 times higher potency with respect to 5-HT 1B receptors (21 nmol / L) than with respect to 5-HT 1A receptors (112 nmol / L). [1] Isamoltan has an anxiolytic effect in rodents. [2]
| Isamoltan | |
|---|---|
 | |
| Chemical compound | |
| IUPAC | 1- (propan-2-ylamino) -3- (2-pyrrol-1-ylphenoxy) propan-2-ol |
| Gross formula | C 16 H 23 ClN 2 O 2 |
| Molar mass | 274.357 g / mol |
| CAS | |
| Pubchem | |
| Classification | |
| Other names | |
| Izamoltan | |
Notes
- ↑ Rényi L., Larsson LG, Berg S., Svensson BE, Thorell G., Ross SB. Biochemical and behavioral effects of isamoltane, a beta-adrenoceptor antagonist with affinity for the 5-HT1B receptor of rat brain. (Eng.) // Naunyn Schmiedebergs Arch Pharmacol. : journal. - 1991. - Vol. 343 , no. 1 . - P. 1-6 . - DOI : 10.1007 / bf00180669 . - PMID 1674359 .
- ↑ Waldmeier PC, Williams M., Baumann PA, Bischoff S., Sills MA, Neale RF. Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with the 5-HT1 receptor subtypes in the rat brain. (Eng.) // Naunyn Schmiedebergs Arch Pharmacol. : journal. - 1988. - Vol. 337 , no. 6 - P. 609-620 . - DOI : 10.1007 / bf00175785 . - PMID 2905765 .