Alprenolol , or Alfeprol ( Gubernal , Regletin , Yobir , Aplobal , Aptin , Aptol Duriles ) is a non - selective β-blocker with moderate partial intrinsic sympathomimetic activity, as well as an antagonist of 5-HT 1A receptors [1] used in the treatment of ischemic heart disease . [2] It is no longer manufactured by Astra Zeneca, but it is still manufactured by a number of other pharmaceutical companies in the form of generics.
| Alprenolol | |
|---|---|
| Alprenolol | |
 | |
| Chemical compound | |
| IUPAC | ( RS ) -1- (ortho-allylphenoxy) -3- (isopropyl-amino) -2-propanol hydrochloride |
| Gross formula | C 15 H 23 NO 2 |
| Molar mass | 249.34 g / mol |
| CAS | |
| Pubchem | |
| Drugbank | |
| Classification | |
| ATH | |
| Pharmacokinetics | |
| Plasma Protein Binding | 80% - 90% |
| The period is half out. | 2-3 hours → 4-OH-alprenolol |
| Mode of administration | |
| Oral | |
| Other names | |
| Aptin, Alfeprol, Alpheprol, Alpresol, Aprobal, Aptin, Aptol, Betacard, Betaptin, Corbetan, Dimacor, Sinalol | |
The chemical structure is close to oxprenolol . Indications for use in cardiac practice are the same as for propranolol and oxprenolol.
Notes
- Jor Bjorvatn B1, Neckelmann D, Ursin R. The 5-HT1A antagonist (-) - alprenolol fails to work. // Pharmacol Biochem Behav .. - May 1992. - V. 42 , no. 42 (1) , No. 1 . - p . 49-56 . - PMID 1388278 .
- ↑ Hickie JB Alprenolol ("aptin") in angina pectoris. A double-blind multicentre trial (Eng.) // Med. J. Aust. : journal. - 1970. - August ( vol. 2 , no. 6 ). - P. 268-272 . - PMID 4393977 .
Links
- Treatment of patients with stable angina D. M. Aronov, V. P. Lupanov State Research Center for Clinical Medicine, Ministry of Health and Social Development of the Russian Federation, Institute of Clinical Cardiology. A. L. Myasnikova of the RCNPK of the Ministry of Health and the Socialist Republic of Russia (inaccessible link)
- Alprenolol (Alprenolol)