| M | Team | AND | AT | N | P | Balls | ± | ABOUT | Notes |
|---|
| one | Bruges | 34 | 24 | five | five | 76 - 31 | +45 | 53 | First round of the 1980/81 Champions Cup |
| 2 | Standard Liege | 34 | 20 | 9 | five | 80 - 31 | +49 | 49 | First round of the UEFA Cup 1980/81 |
| 3 | Molenbek | 34 | nineteen | ten | five | 57 - 28 | +29 | 48 |
| four | Lokeren | 34 | 18 | 6 | ten | 60 - 28 | +32 | 42 |
| five | Anderlecht | 34 | 17 | 7 | ten | 64 - 34 | +30 | 41 |
| 6 | Liers | 34 | 18 | four | 12 | 72 - 43 | +29 | 40 |
| 7 | Watershey Thor Genk | 34 | 14 | 9 | eleven | 50 - 39 | +11 | 37 | First round of the 1980/81 Cup Cup |
| eight | Winterslag Genk | 34 | 12 | eleven | eleven | 35 - 62 | −27 | 35 |
| 9 | Liege | 34 | 12 | 9 | 13 | 51 - 47 | +4 | 33 |
| ten | Circle Brugge | 34 | 13 | 6 | 15 | 51 - 60 | −9 | 32 |
| eleven | Beveren | 34 | eleven | ten | 13 | 34 - 45 | −11 | 32 |
| 12 | Waregem | 34 | ten | eleven | 13 | 33 - 42 | −9 | 31 |
| 13 | Antwerp | 34 | ten | eight | sixteen | 42 - 49 | −7 | 28 |
| 14 | Beershot | 34 | eight | eleven | 15 | 37 - 52 | −15 | 27 |
| 15 | Beringen | 34 | 9 | eight | 17 | 34 - 51 | −17 | 26 |
| sixteen | Burham | 34 | 7 | 12 | 15 | 40 - 61 | −21 | 26 |
| 17 | Charleroi | 34 | eight | 6 | 20 | 23 - 66 | −43 | 22 | Departure to the Second Division 1980/81 |
| 18 | Hasselt | 34 | 2 | 6 | 26 | 21 - 94 | −73 | ten |
And - games, B - wins, N - draws, P - losses, Goals - goals scored and goals conceded, ± - goal difference, O - points