CFU-Meg , or CFU-Meg , or promegacaryoblast , a “ megakaryocyte colony forming unit ” is a hematopoietic stem cell , the earliest precursor of a megakaryocyte ( platelet ) hematopoietic germ, a direct precursor to megakaryoblasts , which then turn into promegacaryocytes . [1] [2] [3] In turn, CFU-Meg (promegacarioblasts) originate from a common myeloid precursor ( CFU-GEMM , promyeloblast).
CFU-Meg |
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Some sources prefer the terms “ CFU-Mega ” (“ CFU-Mega ”) or “ CFU-Me ” (“ CFU-Me ”). [four]
Notes
- ↑ Kimura H., Ohkoshi T., Matsuda S., Uchida T., Kariyone S. Megakaryocytopoiesis in polycythemia vera: characterization by megakaryocytic progenitors (CFU-Meg) in vitro and quantitation of marrow megakaryocytes (Eng.) // Acta Haematol. : journal. - 1988. - Vol. 79 , no. 1 . - P. 1-6 . - DOI : 10.1159 / 000205681 . - PMID 3124455 .
- ↑ Kimura H., Ishibashi T., Sato T., Matsuda S., Uchida T., Kariyone S. Megakaryocytic colony formation (CFU-Meg) in essential thrombocythemia: quantitative and qualitative abnormalities of bone marrow CFU-Meg (Eng.) // Am. J. Hematol. : journal. - 1987 .-- January ( vol. 24 , no. 1 ). - P. 23-30 . - DOI : 10.1002 / ajh.2830240104 . - PMID 3799592 .
- ↑ Gallicchio VS, Hughes NK, Hulette BC, Noblitt L. Effect of interleukin-1, GM-CSF, erythropoietin, and lithium on the toxicity associated with 3'-azido-3'-deoxythymidine (AZT) in vitro on hematopoietic progenitors ( CFU-GM, CFU-MEG, and BFU-E) using murine retrovirus-infected hematopoietic cells (Eng.) // J. Leukoc. Biol. : journal. - 1991 .-- December ( vol. 50 , no. 6 ). - P. 580-586 . - PMID 1940611 . (inaccessible link)
- ↑ Cotran, Ramzi S .; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L .; Abbas, Abul K. Robbins and Cotran pathologic basis of disease. - St. Louis, Mo: Elsevier Saunders, 2005 .-- P. 621. - ISBN 0-7216-0187-1 .