The normoblast , or erythroblast ( ancient Greek ἐρυθρός - “red” and βλαστός - “germ”), is the precursor cell of the red (erythroid) blood sprout, which still has a nucleus . Normoblasts are the immediate precursors of reticulocytes , that is, young red blood cells .
Content
Terminology
The term normoblast is sometimes used as a synonym for erythroblast , but in other cases it is generally accepted that normoblasts are a subcategory (particular case) of erythroblasts. Namely, in such a case, two categories of erythroblasts are distinguished:
- "Normoblasts" - correctly, normally developing erythroblasts;
- " Megaloblasts " - unusually large erythroblasts that can be observed with a deficiency of vitamin B12 or folic acid (megaloblastic anemia);
Stages of development
Normoblast goes through four stages of its development.
Diagram illustrating the process of human hemopoiesis
| Schematic illustration | Description | View in smear microscopy |
| Proeritroblast (pronormoblast, preprorubricite) | Not | |
| Basophilic normoblast (prurubicite) | ||
| Polychromatophilic normoblast (polychromatic normoblast, rubricite) | ||
| Orthochromatophilic normoblast (orthochromatic normoblast, metarubritic) |
Literature
- Erythroblasts // Elocation - Yaya. - Moscow : Soviet Encyclopedia, 1957. - P. 159. - ( Great Soviet Encyclopedia : [in 51 t.] / Ed. B.A. Vvedensky ; 1949-1958, vol. 49).