CEPP is the acronym commonly used in oncohematology for the name of one of the chemotherapy regimens . Designed for the treatment of aggressive lymphomas . Unlike CHOP , this regimen does not contain doxorubicin or similar anthracyclines, therefore it can be used in elderly patients and in patients with cardiovascular diseases . There are 2 options for the CEPP regimen - with the addition of bleomycin - CEPP (B) and without - just CEPP. [one]
Also, this regimen, unlike CHOP, does not contain vincristine and can be used in patients with neuropathies.
In combination with rituximab monoclonal antibody, this chemotherapy regimen is called R-CEPP (B).
The [R] -CEPP (B) mode consists of:
- Rituximab - (R) ituximab - a monoclonal antibody capable of destroying both healthy CD20- bearing B-lymphocytes and malignant ;
- Cyclophosphamide - (C) yclophosphamide - an alkylating antitumor drug ;
- Etoposide - (E) toposide - an topoisomerase inhibitor from the epipodophyllotoxin group;
- Procarbazine - (P) rocarbazine - an anti-tumor drug of an alkylating type of action;
- Prednisolone - (P) rednisone - a glucocorticoid hormone with the ability to cause apoptosis and lysis of lymphocytes , both normal and malignant ;
- Bleomycin - (B) leomycin - an antitumor antibiotic .
Dosage
| Medicine | Dose | Route of administration | Cycle days |
|---|---|---|---|
| Rituximab - (R) ituximab | 375 mg / m 2 | Intravenous infusion | Day 1 |
| Cyclophosphamide - (C) yclophosphamide | 600 mg / m 2 | Intravenous infusion | Days 1 and 8 |
| Etoposide - (E) toposide | 70 mg / m 2 | Intravenous infusion | Days 1-3 |
| Procarbazine - (P) rocarbazine | 60 mg / m 2 | Oral in 4 divided doses | Days 1-10 |
| Prednisolone - (P) rednisolone | 60 mg / m 2 | Oral in 4 divided doses | Days 1-10 |
| Bleomycin - (B) leomycin | 10 IU / m 2 | Bolus intravenously | Day 1 |