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Cyclin D1

Cyclin D1 is a protein from the cyclin family that specifically regulates the G1 / S phase transition in the cell cycle. In humans, it is encoded by the CCND1 gene located at chromosome locus 11q13. [1] [2]

Cyclin D1
Protein CCND1 PDB 2W96.png
Available Structures
PDBSearch:
PDB ID List

Identifiers
, BCL1, D11S287E, PRAD1, U21B31, cyclin D1
External IDs
Associated Hereditary Diseases
Disease nameReferences
Myeloma
Gene ontology
Functions

Cell component

Biological process

Sources: Amigo / QuickGO
RNA expression profile
PBB GE CCND1 208712 at fs.png

PBB GE CCND1 208711 s at fs.png
Orthologists
KindsPersonMouse
Entrez
Ensembl
Uniprot
RefSeq (mRNA)

RefSeq (protein)

Locus (UCSC)
PubMed Search
Wikidata
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Content

  • 1 Function
  • 2 Interactions
  • 3 Additional reading
  • 4 References

Function

Cyclin D1 belongs to the family of evolutionarily very conserved proteins - cyclins . Members of this family are characterized by a sharp dependence of the content of these proteins in the cell on the phase of the cell cycle. Cyclins function as regulators of the so-called cyclin-dependent kinases (CDKs). Different cyclins exhibit different patterns of expression and degradation in different phases of the cell cycle. In the complex, all this contributes to strict temporal coordination of the work of various intracellular signaling cascades during each mitotic event and the correct course of the cell cycle. So, in particular, cyclin D1 forms a complex with cyclin-dependent kinases CDK4 and CDK6, and serves as a regulatory subunit of these kinases (activates them). In turn, the cyclin D1 / CDK4 complex or cyclin D1 / CDK6 activates (phosphorylates) the so-called Rb retinoblastoma protein (tumor suppressor), which contributes to the progression of the cell cycle and the transition from G1 to S phase. And the expression of the cyclin D1 gene, in turn, is positively regulated by the Rb protein. Mutations, amplification, and overexpression of the cyclin D1 gene, accelerating cell cycle progression and cell division, are often observed in various tumors and may contribute to oncogenesis (tumor development).

 
Cyclin D1 staining for the diagnosis of mantle cell lymphoma

Immunohistochemical staining for cyclin D1 is used to diagnose mantle cell lymphoma .

It was also found that cyclin D1 is overexpressed in breast cancer cells . Its use as a potential biomarker has been proposed. [3]

Interactions

Cyclin D1 interacts with the following proteins and genes:

  • NR3C4 , [4] [5] [6]
  • BRCA1 , [7] [8]
  • CCNDBP1 , [9]
  • CDK4 , [10] [11] [12] [13] [14] [15]
  • CDK6 , [10] [12]
  • ESR1 [7] [8] [16] [17]
  • HDAC3 , [5] [18]
  • HDACs , [19]
  • NEUROD1 , [20]
  • NCOA1 , [21]
  • NRF1 , [22]
  • p300 , [23]
  • PACSIN2 , [24]
  • PCNA , [25] [26]
  • PPARG , [27]
  • RAD51 , [28]
  • RB1 , [29] [30]
  • TAF1 , [29] [31] and
  • NR1A2 . [eighteen]

Additional Reading

  • Akita H. [Prognostic importance of altered expression of cell cycle regulators in lung cancer] // Nippon Rinsho: journal. - 2003. - Vol. 60 Suppl 5 . - P. 267—271 . - PMID 12101670 .
  • Chung DC Cyclin D1 in human neuroendocrine: tumorigenesis (Eng.) // Ann. NY Acad. Sci. : journal. - 2004. - Vol. 1014 . - P. 209-217 . - DOI : 10.1196 / annals.1294.022 . - PMID 15153436 .
  • Jain S., Khuri FR, Shin DM Prevention of head and neck cancer: current status and future prospects (English) // Current Problems in Cancer: journal. - 2004. - Vol. 28 , no. 5 . - P. 265-286 . - DOI : 10.1016 / j.currproblcancer.2004.05.00.00 . - PMID 15375804 .
  • Gladden AB, Diehl JA Location, location, location: the role of cyclin D1 nuclear localization in cancer (Eng.) // J. Cell. Biochem. : journal. - 2006. - Vol. 96 , no. 5 . - P. 906-913 . - DOI : 10.1002 / jcb.20613 . - PMID 16163738 .
  • Walker JL, Assoian RK Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression (English) // Cancer Metastasis Rev. : journal. - 2006. - Vol. 24 , no. 3 . - P. 383–393 . - DOI : 10.1007 / s10555-005-5130-7 . - PMID 16258726 .
  • Gautschi O., Ratschiller D., Gugger M., et al. Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation (Eng.) // Lung Cancer: journal. - 2007. - Vol. 55 , no. 1 . - P. 1-14 . - DOI : 10.1016 / j.lungcan.2006.09.024 . - PMID 17070615 .
  • Li Z., Wang C., Prendergast GC, Pestell RG Cyclin D1 functions in cell migration (Eng.) // Cell Cycle : journal. - 2007. - Vol. 5 , no. 21 . - P. 2440-2442 . - DOI : 10.4161 / cc.5.21.3428 . - PMID 17106256 .
  • Tao Zhang, Breslin MB, Lan MS Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest (Eng.) // J. Biol. Chem. : journal. - 2009. - Vol. 284 , no. 9 . - P. 5574–5581 . - DOI : 10.1074 / jbc.M808843200 . - PMID 19124461 .
  • Inaba T., Matsushime H., Valentine M., et al. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes (Eng.) // Genomics : journal. - Academic Press , 1992. - Vol. 13 , no. 3 . - P. 565-574 . - DOI : 10.1016 / 0888-7543 (92) 90126-D . - PMID 1386335 .
  • Schuuring E., Verhoeven E., Mooi WJ, Michalides RJ Identification and cloning of two overexpressed genes, U21B31 / PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas (English) // Oncogene : journal. - 1992. - Vol. 7 , no. 2 . - P. 355-361 . - PMID 1532244 .
  • Seto M., Yamamoto K., Iida S., et al. Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t (11; 14) (q13; q32) translocation (Eng.) // Oncogene : journal. - 1992. - Vol. 7 , no. 7 . - P. 1401-1406 . - PMID 1535701 .
  • Rosenberg CL, Wong E., Petty EM, et al. PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma (Eng.) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 1991. - Vol. 88 , no. 21 . - P. 9638-9642 . - DOI : 10.1073 / pnas.88.21.9638 . - PMID 1682919 .
  • Xiong Y., Connolly T., Futcher B., Beach D. Human D-type cyclin (Eng.) // Cell . - Cell Press 1991. - Vol. 65 , no. 4 . - P. 691-699 . - DOI : 10.1016 / 0092-8674 (91) 90100-D . - PMID 1827756 .
  • Withers DA, Harvey RC, Faust JB, et al. Characterization of a candidate bcl-1 gene (Eng.) // Mol. Cell. Biol. : journal. - 1991. - Vol. 11 , no. 10 . - P. 4846-4853 . - PMID 1833629 .
  • Tsujimoto Y., Yunis J., Onorato-Showe L., et al. Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t (11; 14) chromosome translocation (Eng.) // Science: journal. - 1984. - Vol. 224 , no. 4656 . - P. 1403-1406 . - DOI : 10.1126 / science.6610211 . - PMID 6610211 .
  • Hall M., Bates S., Peters G. Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins (English) // Oncogene : journal. - 1995. - Vol. 11 , no. 8 . - P. 1581-1588 . - PMID 7478582 .
  • Tassan JP, Jaquenoud M., Léopold P., et al. Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C // Proceedings of the National Academy of Sciences of the United States of America : journal. - 1995. - Vol. 92 , no. 19 . - P. 8871-8875 . - DOI : 10.1073 / pnas . 92.19.8871 . - PMID 7568034 .
  • Fornaro M., Dell'Arciprete R., Stella M., et al. Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas (Eng.) // Int. J. Cancer : journal. - 1995. - Vol. 62 , no. 5 . - P. 610-618 . - DOI : 10.1002 / ijc.2910620520 . - PMID 7665234 .
  • Motokura T., Arnold A. PRAD1 / cyclin D1 proto-oncogene: genomic organization, 5 'DNA sequence, and sequence of a tumor-specific rearrangement breakpoint (Eng.) // Genes Chromosomes Cancer : journal. - 1993. - Vol. 7 , no. 2 . - P. 89-95 . - DOI : 10.1002 / gcc.2870070205 . - PMID 7687458 .

Links

  1. ↑ Motokura T., Bloom T., Kim HG, Juppner H., Ruderman JV, Kronenberg HM, Arnold A. A novel cyclin encoded by a bcl1-linked candidate oncogene (Eng.) // Nature: journal. - 1991 .-- May ( vol. 350 , no. 6318 ). - P. 512-515 . - DOI : 10.1038 / 350512a0 . - PMID 1826542 .
  2. ↑ Lew DJ, Dulic V., Reed SI Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast (English) // Cell : journal. - Cell Press 1991. - October ( vol. 66 , no. 6 ). - P. 1197-1206 . - DOI : 10.1016 / 0092-8674 (91) 90042-W . - PMID 1833066 .
  3. ↑ He Y. Expression and significance of Wnt signaling components and their target genes in breast carcinoma .. (Eng.) // J Mol Med Rep: journal. - 2014 .-- January ( vol. 9 , no. 1 ). - P. 137-143 . - DOI : 10.3892 / mmr.2013.1774 . - PMID 24190141 .
  4. ↑ Reutens AT, Fu M., Wang C., Albanese C., McPhaul MJ, Sun Z., Balk SP, Jänne OA, Palvimo JJ, Pestell RG. Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300 / CBP-associated factor (P / CAF) -dependent manner (Eng.) // Mol Endocrinol : journal. - 2001 .-- May ( vol. 15 , no. 5 ). - P. 797-811 . - DOI : 10.1210 / mend.15.5.0641 . - PMID 11328859 .
  5. ↑ 1 2 Petre-Draviam CE, Williams EB, Burd CJ, Gladden A., Moghadam H., Meller J., Diehl JA, Knudsen KE A central domain of cyclin D1 mediates nuclear receptor corepressor activity (Eng.) // Oncogene : journal. - 2005 .-- January ( vol. 24 , no. 3 ). - P. 431-444 . - DOI : 10.1038 / sj.onc.1208200 . - PMID 15558026 .
  6. ↑ Knudsen KE, Cavenee WK, Arden KC D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability (Eng.) // Cancer Research : journal. - American Association for Cancer Research 1999. - May ( vol. 59 , no. 10 ). - P. 2297-2301 . - PMID 10344732 .
  7. ↑ 1 2 Wang C., Fan S., Li Z., Fu M., Rao M., Ma Y., Lisanti MP, Albanese C., Katzenellenbogen BS, Kushner PJ, Weber B., Rosen EM, Pestell RG. Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity. (English) // Cancer Research : journal. - American Association for Cancer Research 2005 .-- August ( vol. 65 , no. 15 ). - P. 6557–6567 . - DOI : 10.1158 / 0008-5472.CAN-05-0486 . - PMID 16061635 .
  8. ↑ 1 2 Casimiro MC, Wang C., Li Z., Di Sante G., Willmart NE, Addya S., Chen L., Liu Y., Lisanti MP, Pestell RG. Cyclin D1 determines estrogen signaling in the mammary gland in vivo. (Eng.) // Mol Endocrinol : journal. - 2013 .-- September ( vol. 27 , no. 9 ). - P. 1415-1428 . - DOI : 10.1210 / me.2013-1065 . - PMID 23864650 .
  9. ↑ Xia C., Bao Z., Tabassam F., Ma W., Qiu M., Hua S., Liu M. GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity // J. Biol. Chem. : journal. - 2000 .-- July ( vol. 275 , no. 27 ). - P. 20942-20948 . - DOI : 10.1074 / jbc.M002598200 . - PMID 10801854 .
  10. ↑ 1 2 Sugimoto M., Nakamura T., Ohtani N., Hampson L., Hampson IN, Shimamoto A., Furuichi Y., Okumura K., Niwa S., Taya Y., Hara E. Regulation of CDK4 activity by a novel CDK4-binding protein, p34 (SEI-1) (Eng.) // Genes Dev. : journal. - 1999 .-- November ( vol. 13 , no. 22 ). - P. 3027-3033 . - DOI : 10.1101 / gad.13.22.3027 . - PMID 10580009 .
  11. ↑ Serrano M., Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D / CDK4 (Eng.) // Nature: journal. - 1993 .-- December ( vol. 366 , no. 6456 ). - P. 704–707 . - DOI : 10.1038 / 366704a0 . - PMID 8259215 .
  12. ↑ 1 2 Lin J., Jinno S., Okayama H. Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence (Eng.) // Oncogene : journal. - 2001 .-- April ( vol. 20 , no. 16 ). - P. 2000-2009 . - DOI : 10.1038 / sj.onc . 1204375 . - PMID 11360184 .
  13. ↑ Taulés M., Rius E., Talaya D., López-Girona A., Bachs O., Agell N. Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G1 ( English) // J. Biol. Chem. : journal. - 1998 .-- December ( vol. 273 , no. 50 ). - P. 33279-33286 . - DOI : 10.1074 / jbc.273.50.33279 . - PMID 9837900 .
  14. ↑ Cariou S., Donovan JC, Flanagan WM, Milic A., Bhattacharya N., Slingerland JM Down-regulation of p21WAF1 / CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells (Eng.) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 2000 .-- August ( vol. 97 , no. 16 ). - P. 9042–9046 . - DOI : 10.1073 / pnas.160016897 . - PMID 10908655 .
  15. ↑ Coleman KG, Wautlet BS, Morrissey D., Mulheron J., Sedman SA, Brinkley P., Price S., Webster KR Identification of CDK4 sequences involved in cyclin D1 and p16 binding (Eng.) // J. Biol. Chem. : journal. - 1997 .-- July ( vol. 272 , no. 30 ). - P. 18869-18874 . - DOI : 10.1074 / jbc.272.30.18869 . - PMID 9228064 .
  16. ↑ Neuman E., Ladha MH, Lin N., Upton TM, Miller SJ, DiRenzo J., Pestell RG, Hinds PW, Dowdy SF, Brown M., Ewen ME Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4 .) // Mol Cell Biol : journal. - 1997 .-- September ( vol. 17 , no. 9 ). - P. 5338-5347 . - PMID 9271411 .
  17. ↑ Zwijsen RM, Wientjens E., Klompmaker R., van der Sman J., Bernards R., Michalides RJ CDK-independent activation of estrogen receptor by cyclin D1 (English) // Cell : journal. - Cell Press 1997 .-- February ( vol. 88 , no. 3 ). - P. 405-415 . - DOI : 10.1016 / s0092-8674 (00) 81879-6 . - PMID 9039267 .
  18. ↑ 1 2 Lin HM, Zhao L., Cheng SY Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors (Eng.) // J. Biol. Chem. : journal. - 2002 .-- August ( vol. 277 , no. 32 ). - P. 28733–28741 . - DOI : 10.1074 / jbc.M203380200 . - PMID 12048199 .
  19. ↑ Fu M., Rao M., Bouras T., Wang C., Wu K., Zhang X., Li Z., Yao TP, Pestell RG Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment (Eng.) // J Biol Chem : journal. - 2006 .-- July ( vol. 280 , no. 17 ). - P. 16934-16941 . - DOI : 10.1074 / jbc.M500403200 . - PMID 15713663 .
  20. ↑ Ratineau C., Petry MW, Mutoh H., Leiter AB Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2 / NeuroD // J. Biol. Chem. : journal. - 2002 .-- March ( vol. 277 , no. 11 ). - P. 8847-8853 . - DOI : 10.1074 / jbc.M110747200 . - PMID 11788592 .
  21. ↑ Zwijsen RM, Buckle RS, Hijmans EM, Loomans CJ, Bernards R. Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1 (Eng.) // Genes Dev. : journal. - 1998 .-- November ( vol. 12 , no. 22 ). - P. 3488—3498 . - DOI : 10.1101 / gad.12.22.3488 . - PMID 9832502 .
  22. ↑ Wang C., Li Z., Lu Y., Du R., Katiyar S., Yang J., Fu M., Leader JE, Quong A., Novikoff PM, Pestell RG. Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function (English) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 2006 .-- July ( vol. 103 , no. 31 ). - P. 11567-11572 . - DOI : 10.1073 / pnas.0603363103 . - PMID 16864783 .
  23. ↑ Fu M., Wang C., Rao M., Wu X., Bouras T., Zhang X., Li Z., Jiao X., Yang J., Li A., Perkins ND, Thimmapaya B., Kung AL , Munoz A., Giordano A., Lisanti MP, Pestell RG Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism. (Eng.) // J Biol Chem : journal. - 2005 .-- August ( vol. 280 , no. 33 ). - P. 29728—29742 . - DOI : 10.1074 / jbc.M503188200 . - PMID 15951563 .
  24. ↑ Meng H., Tian L., Zhou J., Li Z., Jiao X., Li WW, Plomann M., Xu Z., Lisanti MP, Wang C., Pestell RG PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b (Eng.) // Mol Cell Biol : journal. - 2011 .-- January ( vol. 10 , no. 1 ). - P. 73-81 . - DOI : 10.4161 / cc.10.1.14243 . - PMID 21200149 .
  25. ↑ Matsuoka S., Yamaguchi M., Matsukage A. D-type cyclin-binding regions of proliferating cell nuclear antigen (Eng.) // J. Biol. Chem. : journal. - 1994 .-- April ( vol. 269 , no. 15 ). - P. 11030-11036 . - PMID 7908906 .
  26. ↑ Xiong Y., Zhang H., Beach D. Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation (Eng.) // Genes Dev. : journal. - 1993 .-- August ( vol. 7 , no. 8 ). - P. 1572-1583 . - DOI : 10.1101 / gad.7.8.1572 . - PMID 8101826 .
  27. ↑ Wang C., Pattabiraman N., Zhou JN, Fu M., Sakamaki T., Albanese C., Li Z., Wu K., Hulit J., Neumeister P., Novikoff PM, Brownlee M., Scherer PE, Jones JG, Whitney KD, Donehower LA, Harris EL, Rohan T., Johns DC, Pestell RG Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation (Eng.) // Mol Cell Biol : journal. - 2003 .-- September ( vol. 23 , no. 17 ). - P. 6159-6173 . - DOI : 10.1128 / mcb.23.17.6159-6173.2003 . - PMID 12917338 .
  28. ↑ Li Z., Jiao X., Wang C., Shirley LA, Elsaleh H., Dahl O., WAng M., Soutoglou E., Knudsen ES, Pestell RG Alternative cyclin D1 splice forms differentially regulate the DNA damage response .) // Cancer Research : journal. - American Association for Cancer Research 2010 .-- November ( vol. 70 , no. 21 ). - P. 8802-8811 . - DOI : 10.1158 / 0008-5472.CAN-10-0312 . - PMID 20940395 .
  29. ↑ 1 2 Siegert JL, Rushton JJ, Sellers WR, Kaelin WG, Robbins PD Cyclin D1 suppresses retinoblastoma protein-mediated inhibition of TAFII250 kinase activity (English) // Oncogene : journal. - 2000 .-- November ( vol. 19 , no. 50 ). - P. 5703-5711 . - DOI : 10.1038 / sj.onc.1203966 . - PMID 11126356 .
  30. ↑ Dowdy SF, Hinds PW, Louie K., Reed SI, Arnold A., Weinberg RA Physical interaction of the retinoblastoma protein with human D cyclins (English) // Cell : journal. - Cell Press 1993 .-- May ( vol. 73 , no. 3 ). - P. 499-511 . - DOI : 10.1016 / 0092-8674 (93) 90137-f . - PMID 8490963 .
  31. ↑ Adnane J., Shao Z., Robbins PD Cyclin D1 associates with the TBP-associated factor TAF (II) 250 to regulate Sp1-mediated transcription (Eng.) // Oncogene : journal. - 1999 .-- January ( vol. 18 , no. 1 ). - P. 239-247 . - DOI : 10.1038 / sj.onc.1202297 . - PMID 9926939 .
Source - https://ru.wikipedia.org/w/index.php?title= Cyclin D1&oldid = 100979981


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