Maud Leonore Menten - Canadian biochemist and histochemist , author of the Michaelis-Menten equation .
| Maud Leonora Menten | |
|---|---|
| him Maud Leonora Menten | |
 Maud Menten | |
| Date of Birth | March 20, 1879 |
| Place of Birth | Port Lambton , Ontario , Canada |
| Date of death | July 20, 1960 (81 years) |
| Place of death | Leamington , Ontario , Canada |
| A country | |
| Scientific field | Biochemistry , Histochemistry , Chemical kinetics |
| Place of work | University of Chicago, University of Pittsburgh |
| Alma mater | University of Toronto |
| Known as | author of the Michaelis-Menten equation |
| Awards and prizes | Introduced into the (1998) [1] |
Biography
Maud Menten was born in 1879 in the village of Port Lambton in the southwest of the Canadian province of Ontario . After graduation, she entered the University of Toronto at the Faculty of Medicine. In 1904 she received a bachelor's degree. In 1907, he worked at Rockefeller University , where he studied the effect of radium bromide on cancerous tumors in rats. In the same year he received a master's degree. And in 1911, Mr .. becomes one of the first women in Canada who received the degree of doctor of medicine. In 1912, he worked in Berlin in collaboration with Leonor Michaelis in the field of kinetics of enzymatic reactions. Menten and Michaelis, on the basis of Victor Henry's early work, are studying the effect of substrate concentration on the reaction rate [2] . In 1913, Michaelis and Menten publish the results of their work in the journal Biochemische Zeitschrift [3] . In 1916 she defended her Ph.D. degree at the University of Chicago . The topic of the thesis was devoted to changes in blood pH in pathological tumors and changes in atmospheric pressure. In the period from 1923 to 1950. worked as a pathologist at the University of Pittsburgh . In 1951, she returned to Canada and until 1953 worked at the Institute of Medical Research in British Columbia . In addition to his scientific work, Menten was fond of drawing, playing the clarinet , astronomy , and had several foreign languages (French, German, Italian, Russian, Khalkomel ) [4] . Maud Menten passed away (17) [5] July 20, 1960 in Leamington, Ontario, Canada [6] .
Scientific Research
In addition to contributing to the study of the kinetics of enzymatic reactions, Menten was the author and co-author of more than 100 scientific publications. In particular, he developed a histochemical method for determining the activity of alkaline phosphatase using the azo coupling reaction [7] . Modifications of this method are still used in histochemistry. The author of works on histopathology and etiology of pneumonia [8] . Identified a number of bacterial toxins B. paratyphosus , Streptococcus scarlatina and Salmonella ssp . The author of the works on the study of blood sugar concentration in various conditions, the function and pathology of the kidneys [9] [10] , the effect of sulfonamides on blood functions [11] [12] , histology of various tumors [13] [14] . One of the pioneers in the field of electrophoretic separation of plasma proteins [15] .
Links
- ↑ Dr. Maud L. Menten | Canadian Medical Hall of Fame
- Ich Deichmann U. , Schuster S. , Mazat JP , Cornish-Bowden A. Commemorating the 1913 Michaelis-Menten paper Die Kinetik der Invertinwirkung: three perspectives. (eng.) // The FEBS journal. - 2014. - Vol. 281, no. 2 P. 435-463. - DOI : 10.1111 / febs.12598 . - PMID 24180270 .
- Is Michaelis L. , Menten ML , Johnson KA , Goody RS The Michaelis-Menten paper. (English) // Biochemistry. - 2011. - Vol. 50, no. 39 - P. 8264-8269. - DOI : 10.1021 / bi201284u . - PMID 21888353 .
- ↑ Rebecca Skloot. Some Called Her Miss Menten .
- Dr. Page Dr. Maud Menten at the Canadian Medical Hall of Fame (not available link) . Archived October 17, 2014.
- ↑ Aaron H. Stock, Anna-Mary Carpenter. Obituary Prof. Maud Menten // Nature. - 1961. - № 189 . - p . 965 .
- ↑ Maud L. Menten, Josephine Junge, and Mary H. Green. A coupling histochemical azo dye test for alkaline phosphatase in the kidney // J. Biol. Chem .. - 1944. - № 153 . - p . 471-477 .
- Ten Menten ML , McCloskey GA Histopathology and Etiology of Pneumonia in Children Dying after Antibacterial Therapy. (Eng.) // The American journal of pathology. - 1951. - Vol. 27, no. 3 - P. 477-491. - PMID 19970982 .
- Ten ML Micro (English) // The Journal of medical research. - 1922. - Vol. 43, no. 3 - P. 323-344. - PMID 19972573 .
- Ten Menten ML Pathological Lesions produced in the Small Doses of Mercuric Chloride. (English) // The Journal of medical research. - 1922. - Vol. 43, no. 3 - P. 315–321. - PMID 19972572 .
- ↑ Menten ML , Graff E. Blood changes related to sulfonamide therapy; granulocytopenia associated with use of sulfonamides. (English) // The American journal of the medical sciences. - 1946. - Vol. 211. - p. 666-671. - PMID 20992691 .
- ↑ Denny HM , Menten ML Blood changes related to sulfonamide therapy; aplastic anemia associated with sulfonamide therapy. (English) // The American journal of the medical sciences. - 1946. - Vol. 211. - p. 659-665. - PMID 20992690 .
- ↑ Weber EJ , Menten ML Histologic studies on a virilizing tumor of the adrenal cortex. (Eng.) // The American journal of pathology. - 1948. - Vol. 24, no. 2 - P. 293-303. - PMID 18904644 .
- Ten Menten ML , Willms M. Nucleic acid cells of bone marrow aspirated from patients with leukemia. (English) // Cancer research. - 1953. - Vol. 13, no. 10 - P. 733-736. - PMID 13094688 .
- ↑ Fischer MA , Steinman PA , Carpenter AM , Menten ML Nephrosis demonstrated by electrophoresis. (Eng.) // The Journal of laboratory and clinical medicine. - 1951. - Vol. 37, no. 6 - P. 894-901. - PMID 14850819 .