CD154

CD154
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Available Structures
PDB	Ortholog Search: PDBe , RCSB
PDB ID List
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Identifiers
Symbol	; CD154; CD40L; HIGM1; IGM; IMD3; T-BAM; TNFSF5; TRAP gp39; hCD40L
External IDs	GeneCards :
Gene ontology
Function	•; •; •;
Cell component	•; •; •; •; •;
Biological process	•; •; •; •; •; •; •; •; •; •; •; •;
	Sources: Amigo / QuickGO
RNA expression profile
Orthologists

CD154 , also a CD40, CD40L ligand, or TNFSF5 ( English Tumor necrosis factor ligand superfamily member 5 ) is a cytokine of the tumor necrosis factor family, mainly localized on activated T-lymphocytes . CD40 receptor ligand expressed on antigen-presenting cells as well as B lymphocytes . Human gene product CD40LG .

Content

Functions

T-lymphocyte- dependent activation of B-lymphocytes . Showing: TH2 cells (left), B-cells (right) and molecules involved in intercellular interaction. The CD40L T helper cytokine interacts with the CD40 receptor on the surface of the B cell.

TNFSF5 (often referred to as CD40L ) is part of a large family of tumor necrosis factors ( TNF ). CD40L plays the role of a costimulatory molecule and induces the activation of antigen-presenting cells during stimulation of the T-cell receptor by the molecules of the main histocompatibility complex located on antigen-presenting cells. Interacts with CD40 and integrins α5β1 ( VLA-5 ) and αIIbβ3 ( glycoprotein IIb / IIIa ).

CD154 is expressed on T lymphocytes . The protein regulates the function of B-lymphocytes by interacting with CD40 on the surface of B-cells.

Structure

Protein exists in two forms: membrane-bound and soluble. The membrane-bound form consists of 261 amino acids, and the molecular weight is 29.3 kDa. Cleavage of the N-terminal fragment (112 amino acids) releases protein into the medium. Contains 1 N-glycosolation site and one intramolecular disulfide bond.

It is a homotrimer.

Pathology

Gene disruptions lead to the inability to switch immunoglobulin classes and are associated with high IgM syndrome. ^[one]

Notes

↑ Entrez Gene: CD40LG CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) (neopr.) .

Literature

Tong AW, Stone MJ CD40 and the effect of anti-CD40-binding on human multiple myeloma clonogenicity (English) // Leuk. Lymphoma : journal. - 1997. - Vol. 21 , no. 1-2 . - P. 1-8 . - DOI : 10.3109 / 10428199609067572 . - PMID 8907262 .
van Kooten C., Banchereau J. CD40-CD40 ligand (English) // J. Leukoc. Biol. : journal. - 2000. - Vol. 67 , no. 1 . - P. 2-17 . - PMID 10647992 .
Schattner EJ CD40 ligand in CLL pathogenesis and therapy (English) // Leuk. Lymphoma : journal. - 2003. - Vol. 37 , no. 5-6 . - P. 461-472 . - DOI : 10.3109 / 10428190009058499 . - PMID 11042507 .
Bhushan A., Covey LR CD40: CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes (English) // Immunol. Res. : journal. - 2002. - Vol. 24 , no. 3 . - P. 311-324 . - DOI : 10.1385 / IR: 24: 3: 311 . - PMID 11817328 .
Cheng G., Schoenberger SP CD40 signaling and autoimmunity (neopr.) // Curr. Dir. Autoimmun .. - 2002. - T. Current Directions in Autoimmunity . - S. 51–61 . - ISBN 3-8055-7308-1 . - DOI : 10.1159 / 000060547 . - PMID 11826760 .
Subauste CS CD154 and type-1 cytokine response: from hyper IgM syndrome to human immunodeficiency virus infection (English) // J. Infect. Dis. : journal. - 2002. - Vol. 185 Suppl 1 . - P. S83-9 . - DOI : 10.1086 / 338003 . - PMID 11865444 .
Kornbluth RS An expanding role for CD40L and other tumor necrosis factor superfamily ligands in HIV infection // J. Hematother. Stem Cell Res. : journal. - 2003. - Vol. 11 , no. 5 . - P. 787-801 . - DOI : 10.1089 / 152581602760404595 . - PMID 12427285 .
Xu Y., Song G. The role of CD40-CD154 interaction in cell immunoregulation (Eng.) // J. Biomed. Sci. : journal. - 2005. - Vol. 11 , no. 4 . - P. 426-438 . - DOI : 10.1159 / 000077892 . - PMID 15153777 .

[1] Entrez Gene: CD40LG CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) (neopr.) .