The lipid membrane on the substrate ( English surface-supported membrane ) is a lipid bilayer stabilized by a solid surface; is a model of biological membranes and has been widely used in biotechnology .
Description
The lipid bilayer can be deposited on solid surfaces: quartz, mica, gold, titanium oxide and a number of other materials. A solid surface provides high stability of the membrane, and a water layer 1–2 nm thick, located between the surface and the membrane, preserves the natural fluidity of the latter. The membranes on the substrate are of research and applied value. In particular, they are a convenient model for studying near-membrane processes at the nanoscale level, for example, by atomic force microscopy methods, or surface plasmon resonance phenomena. From an applied point of view, these membranes can be used in analytical and diagnostic sensors, in microchips and microfluidic devices . The main operational properties are selective permeability, biocompatibility and structural function (for example, membranes are widely used as a carrier for transmembrane proteins).
Literature
- Castellana ET, Cremer PS Solid supported lipid bilayers: From biophysical studies to sensor design. - Surface Science Reports, 2006. - S. 429–444.