2-Chloropropyl-bis- (β-chloroethyl) -amine hydrochloride , also known as novembihin . A cytostatic antitumor chemotherapeutic drug with an alkylating type of action. By chemical structure it is a derivative of bis-β-chloroethylamine .
| 2-chloropropyl-bis- (β-chloroethyl) -amine hydrochloride | |
|---|---|
| Chemical compound | |
| Gross formula | C 7 H 14 Cl 3 N |
| Cas | |
| PubChem | |
Mechanism of Action
2-Chloropropyl-bis- (β-chloroethyl) -amine hydrochloride is a cytostatic alkylating derivative of bis-β-chloroethylamines, contains highly reactive chloroethylamine groups. It easily reacts with nucleoproteins of cell nuclei, due to which the process of cell growth and reproduction is disrupted. Dividing cells of the hematopoietic system, some tumors of the corneal and intestinal epithelium are more sensitive to cytostatic effects. 2-Chlorpropyl-bis- (β-chloroethyl) -amine interacts with proteins, including enzyme proteins, which in turn leads to a violation of the energy balance of the cell. The compound is highly toxic, has pronounced irritating and necrotic properties.
Historical Indications
Lymphogranulomatosis of the I — III stages, chronic lymphoid leukemia , true polycythemia .
Contraindications
Severe myelosuppression, severe anemia , leukopenia , thrombocytopenia , terminal stages of cancer , severe malnutrition , acute leukemia, the transition of chronic leukemia to acute (blast transformation or blast crisis); decompensation of cardiac activity , severe liver and kidney diseases .