Thrombomodulin (CD141 or BDCA-3) is an integral membrane protein , a thrombin receptor located on the endothelial cells of blood vessels and participating in the anticoagulation system. It actively limits and regulates blood coagulation .
| Thrombomodulin | |||||||||||||
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 PDB is drawn based on 1adx. | |||||||||||||
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| Symbol | ; AHUS6; BDCA3; CD141; THPH12; THRM; TM | ||||||||||||
| External IDs | GeneCards : | ||||||||||||
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| Uniprot | |||||||||||||
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Content
Structure
It consists of a single chain dividing into 5 distinct domains, among which there is a domain typical of type C lectins . Molecular Weight — 74.000.
Function
It functions as a cofactor in the process of activating protein C with thrombin . Thrombomodulin, located on the membrane of endothelial cells, binds a thrombin molecule from the blood. In this case, the resulting complex accelerates the activation of protein C by a factor of 1000. Moreover, the associated thrombin is excluded from the blood coagulation system.
Pathology
Thrombomodulin is significantly reduced in certain diseases, such as atherosclerosis , which can increase blood clotting and increase the risk of thrombosis .
See also
- Coagulation (hematology)
- Protein C